Piceatannol upregulates USP14-mediated GPX4 deubiquitination to inhibit neuronal ferroptosis caused by cerebral ischemia-reperfusion in mice

Food and Chemical Toxicology, Год журнала: 2025, Номер unknown, С. 115281 - 115281

Опубликована: Янв. 1, 2025

Язык: Английский

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E3 ubiquitin ligase DTX2 fosters ferroptosis resistance via suppressing NCOA4-mediated ferritinophagy in non-small cell lung cancer

Drug Resistance Updates, Год журнала: 2024, Номер 77, С. 101154 - 101154

Опубликована: Сен. 28, 2024

Язык: Английский

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Iron Overload Accompanying Extracellular Acidosis and Neurodegeneration

Опубликована: Июнь 13, 2024

The dynamic equilibrium of iron homeostasis has an important role in sustaining metabolic and neurological functions during human life. Iron excretion is modest unregulated hence this overall tightly regulated normal conditions by increasing deficient or limiting excessive assimilation. Here we focus on neural tissue overload, dyshomeostasis that preceded assimilation, disturbances internal both. Normal steps include its uptake across the apical membrane enterocytes a mildly acidic duodenal milieu major importer ferrous iron, Divalent Metal Transporter 1 (DMT1) (Nramp2/DCT1/SLC11A2, solute carrier family 11 member 2) [1, 2], responsible for Non-Transferrin Bound (NTBI) divalent metals [3], passage through bound to chaperone crossing basal via only known cellular exporter, ferroportin [4] with transferrin (Tf) as it exits. Cells peripheral tissues largely utilize circulating after receptor-mediated endocytosis Tf-bound [5]. Derangement NTBI absorption heavy influenced systemic metabolism associated inflammation leads accumulation into potential development neurodegenerative diseases, involving distribution fine regulation DMT1 also central nervous system, where inflammatory-related acidosis influences uptake, action proton cotransporter. Pharmacological strategies inhibit transport selectively will be illustrated relationship protection, particularly neuroprotection, against overload acidosis, inflammation, neuroinflammation subsequent neurodegeneration.

Язык: Английский

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Involvement of ubiquitination in Alzheimer’s disease

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Сен. 5, 2024

The hallmark pathological features of Alzheimer's disease (AD) consist senile plaques, which are formed by extracellular β-amyloid (Aβ) deposition, and neurofibrillary tangles, the hyperphosphorylation intra-neuronal tau proteins. With increase in clinical studies,

Язык: Английский

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