Cholinesterase Inhibitory Activity of Paeoniflorin: Molecular Dynamics Simulation, and In Vitro Mechanistic Investigation DOI Creative Commons
Mohnad Abdalla,

Asaad Khalid,

Jasmine Hedayati

и другие.

Biochemistry Research International, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

Alzheimer’s disease (AD), a neurological disorder, is one of the major reasons for memory loss in world. AD characterized by sequela cognitive and functional decline caused brain cell degeneration. Paeoniflorin monoterpenoid glycoside found plants Paeoniaceae family, which are known their medicinal properties including dementia. In this project, we report actions paeoniflorin on two related cholinesterases (ChE): acetylChE (AChE) butyrylChE (BuChE). Paeoniflorin, dose‐dependent (maximum inhibition at 1 mg/mL) manner, inhibited both AChE (0.06–1 BuChE (0.007–1 enzymes with maximum enzyme 90.3 ± 1.4%, while 99.4 0.3% enzyme. The EC 50 value inhibitory effect compound against was 0.52 mg/mL (0.18–1.52), 0.13 (0.08–0.21). observed ani‐ChE action like an also mediated ChE blocker physostigmine. Molecular interactions between were additionally sought via molecular docking dynamics simulations 100 ns, that showed interacted active‐site gorge hydrogen bonds water bridging many amino acids enzymes. This study presents potential With kind activity, chemical can potentially increase ACh levels may have use treatment dementia AD.

Язык: Английский

Phytochemical-based therapeutics from traditional eastern medicine: analgesic effects and ion channel modulation DOI Creative Commons
Sung Eun Kim, Geehoon Chung, Sun Kwang Kim

и другие.

Frontiers in Pain Research, Год журнала: 2025, Номер 6

Опубликована: Янв. 31, 2025

Pain management remains a major challenge in the healthcare system. While synthetic analgesics are widely used for pain management, their effectiveness managing chronic is often limited due to low efficacy or side effects. Thus, there growing interest exploring alternative relief methods, particularly using medicinal plants from traditional Eastern medicine and phytochemicals. Previous studies have demonstrated modulatory effects of various phytochemicals derived herbal on pain-related ion channels, such as voltage-gated sodium channels (Nav), calcium (Ca2+), transient receptor potential (TRP) channels. Since these integral transmission modulation signals, ability specific activate inhibit presents promising avenue development novel analgesics. The goal this review merge insights with channel research highlight natural compounds safe effective management. In regard, we summarize discovery characterization pain-relieving medicine, discuss mechanisms action mimic enhance conventional through modulation.

Язык: Английский

Процитировано

1
Analysis of Blood Migration Components in Rats Treated with Shaoyao Gancao Decoction using UPLC-Q-TOF-MS/MS DOI Creative Commons
Lingfang Wu,

Yifei Ren,

Yingying Li

и другие.

Heliyon, Год журнала: 2025, Номер unknown, С. e42753 - e42753

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Prospective Approaches to the Sustainable Use of Peonies in Bulgaria DOI Creative Commons
Christina Stoycheva, Daniela Batovska, Giuseppe Antonio Malfa

и другие.

Plants, Год журнала: 2025, Номер 14(6), С. 969 - 969

Опубликована: Март 19, 2025

In Europe, Paeonia officinalis and P. peregrina, along with Chinese lactiflora, are commonly used for medicinal purposes. This comprehensive review summarizes the secondary metabolites biological activities of officinalis, tenuifolia, mascula, ornamental cultivars derived from last taxon. Terpenoids, flavonoids, phenolic acids present in all five species, while tannins, lipids, organic have been identified only some. All species exhibit antioxidant antimicrobial potential, alongside anti-inflammatory, anticancer, neuroprotective, antisclerotic, antidiabetic, various other bioactivities. The data were accessed via Scopus, Web Science, PubMed, Google Scholar search engines. also reveals that lactiflora far more extensively studied than mascula terms their chemical composition pharmacological properties. genus L. comprises 37 accepted many which renowned value. Native to Bulgaria latter two being protected by Bulgarian Biodiversity Act. collection substances three is subject regulatory restrictions. possible use as a substitute peregrina.

Язык: Английский

Процитировано

0
Paeoniflorin Directly Targets ENO1 to Inhibit M1 Polarization of Microglia/Macrophages and Ameliorates EAE Disease DOI Open Access
Ying Sun, Guojue Wang, Shengzhe Li

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3677 - 3677

Опубликована: Апрель 13, 2025

The chronic autoimmune disease multiple sclerosis (MS) now remains incurable. Paeoniflorin (PF), which is a monoterpene glucoside obtained from Paeonia lactiflora Pall, recognized for neuroprotective and anti-inflammatory properties. However, the precise mechanism by PF regulates MS unclear. This work aims to elucidate underlying mechanisms of in EAE, well established animal model MS, discover target proteins that directly acts on. Our results revealed administration can significantly attenuate clinical symptoms EAE alleviate central nervous system (CNS) inflammatory environment inhibiting M1-type microglia/macrophages. Mechanistically, was found interact with glycolytic enzyme α-enolase (ENO1), its enzymatic activity expression impair glucose metabolism, thereby suppressing microglia/macrophage M1 polarization ameliorating CNS inflammation. Significantly, Eno1 knockdown microglia/macrophages diminished their pro-inflammatory phenotype, while treatment ENOBlock or specific knockout microglia led remission, underscoring critical role ENO1 progression. study uncovers molecular treating linking property metabolism process, will broaden prospective applications PF.

Язык: Английский

Процитировано

0
Traditional Chinese Medicine for Hashimoto’s Thyroiditis: Focus on Selenium and Antioxidant Phytochemicals DOI Creative Commons
Sheng Huang, Panos G. Ziros, Dionysios V. Chartoumpekis

и другие.

Antioxidants, Год журнала: 2024, Номер 13(7), С. 868 - 868

Опубликована: Июль 19, 2024

Hashimoto's thyroiditis (HT) is not only the most frequent autoimmune thyroid disease (AITD), but it also has a significant impact on patients' health-related quality of life (HRQoL), and been variably associated with differentiated carcinoma. Even though its pathogenesis still incompletely understood, oxidative stress believed to play an important role. Hypothyroidism related later stages HT can be treated levothyroxine substitution therapy; various approaches such as selenium supplementation iodine-restricted diets have proposed disease-modifying treatments for earlier stages, even thyroidectomy suggested refractory cases painful HT. Nevertheless, many patients report suboptimal HRQoL, highlighting unmet medical need in this area. The concepts traditional Chinese medicine (TCM) treating are broadly known West. Here, we provide overview TCM HT, including combinations selenium. We encompass evidence from clinical trials other studies complex prescriptions, single herbs used TCM, phytochemicals; wherever possible, delineate probable underlying molecular mechanisms. findings show that main active components commonly or presumed antioxidant anti-inflammatory activities, which may account their potential utility Further exploring practices combining them evidence- mechanism-based according Western standards help identify new strategies alter course and/or treat symptoms better improve HRQoL.

Язык: Английский

Процитировано

1
Cholinesterase Inhibitory Activity of Paeoniflorin: Molecular Dynamics Simulation, and In Vitro Mechanistic Investigation DOI Creative Commons
Mohnad Abdalla,

Asaad Khalid,

Jasmine Hedayati

и другие.

Biochemistry Research International, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

Alzheimer’s disease (AD), a neurological disorder, is one of the major reasons for memory loss in world. AD characterized by sequela cognitive and functional decline caused brain cell degeneration. Paeoniflorin monoterpenoid glycoside found plants Paeoniaceae family, which are known their medicinal properties including dementia. In this project, we report actions paeoniflorin on two related cholinesterases (ChE): acetylChE (AChE) butyrylChE (BuChE). Paeoniflorin, dose‐dependent (maximum inhibition at 1 mg/mL) manner, inhibited both AChE (0.06–1 BuChE (0.007–1 enzymes with maximum enzyme 90.3 ± 1.4%, while 99.4 0.3% enzyme. The EC 50 value inhibitory effect compound against was 0.52 mg/mL (0.18–1.52), 0.13 (0.08–0.21). observed ani‐ChE action like an also mediated ChE blocker physostigmine. Molecular interactions between were additionally sought via molecular docking dynamics simulations 100 ns, that showed interacted active‐site gorge hydrogen bonds water bridging many amino acids enzymes. This study presents potential With kind activity, chemical can potentially increase ACh levels may have use treatment dementia AD.

Язык: Английский

Процитировано

1