Unraveling the AMPK-SIRT1-FOXO Pathway: The In-Depth Analysis and Breakthrough Prospects of Oxidative Stress-Induced Diseases
Antioxidants,
Год журнала:
2025,
Номер
14(1), С. 70 - 70
Опубликована: Янв. 9, 2025
Oxidative
stress
(OS)
refers
to
the
production
of
a
substantial
amount
reactive
oxygen
species
(ROS),
leading
cellular
and
organ
damage.
This
imbalance
between
oxidant
antioxidant
activity
contributes
various
diseases,
including
cancer,
cardiovascular
disease,
diabetes,
neurodegenerative
conditions.
The
body’s
system,
mediated
by
signaling
pathways,
includes
AMPK-SIRT1-FOXO
pathway.
In
oxidative
conditions,
AMPK,
an
energy
sensor,
activates
SIRT1,
which
in
turn
stimulates
FOXO
transcription
factor.
cascade
enhances
mitochondrial
function,
reduces
damage,
mitigates
OS-induced
injury.
review
provides
comprehensive
analysis
biological
roles,
regulatory
mechanisms,
functions
pathway
diseases
influenced
OS,
offering
new
insights
methods
for
understanding
OS
pathogenesis
its
therapeutic
approaches.
Язык: Английский
The Role of Antioxidants in Preventing Chronic Kidney Disease Progression: Mechanisms and Clinical Implications
Indus journal of bioscience research.,
Год журнала:
2025,
Номер
3(2), С. 616 - 630
Опубликована: Март 11, 2025
This
study
aims
to
investigate
the
determinants
of
progression
Chronic
Kidney
Disease
(CKD)
and
role
antioxidant
supplementation
in
managing
oxidative
stress
kidney
function.
The
research
used
a
cross-sectional
with
120
participants,
considering
variables
such
as
age,
gender,
smoking,
family
history,
diet,
alcohol
consumption,
education,
occupation.
Key
findings
from
analysis
were
that
age
was
significant
contributing
factor
CKD
progression,
older
individuals
having
greater
likelihood
developing
advanced
disease
stages.
Males,
particularly
those
hypertension,
had
increased
prevalence
damage.
Smoking
also
found
accelerate
intake
diet
rich
fruits
vegetables
being
associated
high
use.
intervention
group,
supplemented
antioxidants,
evidenced
remarkable
reductions
indicators
well
improvement
function
compared
existing
levels,
shown
by
statistical
comparison
through
Paired
t-tests
Wilcoxon
Signed-Rank
Tests
(p
<
0.05).
control
on
other
hand,
experienced
no
similar
alterations.
In
addition,
multivariable
regression
model
proved
impact
baseline
function,
comorbid
illness
outcomes
poorer
patients
reduced
eGFR.
suggest
lifestyle
modifications
smoking
abstinence
change,
may
have
are
potential
targets
for
clinical
intervention.
highlights
key
influencing
emphasizing
modifiable
risk
factors
like
use,
physical
activity.
Findings
support
crucial
strategies
slowing
improving
renal
health
outcomes.
Язык: Английский
Activation, interaction and intimation of Nrf2 pathway and their mutational studies causing Nrf2 associated cancer
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,
Год журнала:
2025,
Номер
1871(5), С. 167764 - 167764
Опубликована: Март 14, 2025
Язык: Английский
Brazil Nut or Not? Uncovering the Best Source of Selenium for chronic non-communicable disease
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106520 - 106520
Опубликована: Апрель 1, 2025
Язык: Английский
Antioxidant Potential of Exosomes in Animal Nutrition
Antioxidants,
Год журнала:
2024,
Номер
13(8), С. 964 - 964
Опубликована: Авг. 8, 2024
This
review
delves
into
the
advantages
of
exosomes
as
novel
antioxidants
in
animal
nutrition
and
their
potential
for
regulating
oxidative
stress.
Although
traditional
nutritional
approaches
promote
stress
defense
systems
mammalian
animals,
several
issues
remain
to
be
solved,
such
low
bioavailability,
targeted
tissue
efficiency,
high-dose
by-effect.
As
an
important
candidate
offering
regulation
opportunities
concerned
with
cellular
communication,
disease
prevention,
physiology
multiple
biological
systems,
mediating
redox
status
has
not
been
well
described.
A
previously
reported
relationship
between
system
circulating
suggested
a
fundamental
both
regulator
biomarker
system.
Herein,
we
effects
on
animals
application
nutrition.
Then,
highlight
regulators
due
higher
bioavailability
physiological
heterogeneity-targeted
properties,
providing
theoretical
foundation
feed
industry
application.
Therefore,
have
shown
great
field
They
can
overcome
limitations
terms
dosage
side
effects,
which
will
provide
unprecedented
management
may
become
major
breakthrough
Язык: Английский
Hydrogen-Rich Water to Enhance Exercise Performance: A Review of Effects and Mechanisms
Metabolites,
Год журнала:
2024,
Номер
14(10), С. 537 - 537
Опубликована: Окт. 7, 2024
:
Hydrogen-rich
water
(HRW)
has
garnered
significant
interest
within
the
sports
and
exercise
science
community
due
to
its
selective
antioxidant
properties.
Despite
potential
benefits,
comprehensive
reviews
specifically
addressing
effects
on
athletic
performance
are
limited.
This
review
aims
assess
impact
of
HRW
explore
underlying
molecular
biological
mechanisms,
with
goal
elucidating
how
might
enhance
performance.
Язык: Английский
The Role of Mast Cells in the Remodeling Effects of Molecular Hydrogen on the Lung Local Tissue Microenvironment under Simulated Pulmonary Hypertension
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 11010 - 11010
Опубликована: Окт. 13, 2024
Molecular
hydrogen
(H2)
has
antioxidant,
anti-inflammatory,
and
anti-fibrotic
effects.
In
a
rat
model
simulating
pulmonary
fibrotic
changes
induced
by
monocrotaline-induced
hypertension
(MPH),
we
had
previously
explored
the
impact
of
inhaled
H2
on
lung
inflammation
blood
pressure.
this
study,
further
focused
biological
effects
mast
cells
(MCs)
parameters
phenotype
local
tissue
microenvironment.
MPH
resulted
in
significantly
increased
number
MCs
both
pneumatic
respiratory
parts
lungs,
an
tryptase-positive
with
expression
TGF-β,
activated
interaction
immunocompetent
(macrophages
plasma
cells)
fibroblasts,
MC
colocalization
fibrous
component
extracellular
matrix
connective
tissue.
The
alteration
properties
population
occurred
together
intensified
collagen
fibrillogenesis
increase
integral
volume
elastic
fibers
exposure
monocrotaline
(MCT),
despite
individual
differences
between
animals,
tended
to
decrease
intrapulmonary
severity
microenvironment
compared
animals
exposed
MCT
effect
alone.
addition,
activity
associated
TGF-β
tryptase
decreased,
accompanied
reduction
absolute
relative
content
reticular
stroma.
Thus,
exposure,
antifibrotic
involving
lungs
rats.
This
reveals
unknown
development
mechanisms
remodeling
features
under
inflammatory
background
conditions
Язык: Английский
Molecular Hydrogen Therapy in Sjögren’s Syndrome With Pulmonary Arterial Hypertension and Right-sided Heart Failure: A Case Report of Improved Immune Markers Including Treg, B Cells and Plasma Cell
In Vivo,
Год журнала:
2024,
Номер
38(6), С. 3117 - 3124
Опубликована: Окт. 29, 2024
Background/Aim:
Connective
tissue
disease-associated
pulmonary
arterial
hypertension
(CTD-PAH)
is
a
severe
complication
characterized
by
elevated
artery
pressure,
which
can
lead
to
right
heart
failure
and
death,
if
untreated.
Standard
treatments
often
fail
adequately
manage
symptoms,
highlighting
the
need
for
novel
therapeutic
approaches.
This
study
investigated
efficacy
of
molecular
hydrogen
(H2)
therapy
in
patient
with
CTD-PAH.
Case
Report:
We
present
case
56-year-old
female
CTD-PAH,
diagnosed
2013
Sjogren's
syndrome
complicated
interstitial
lung
disease
(ILD)
PAH.
Despite
treatment
sildenafil,
bosentan,
macitentan,
iloprost,
corticosteroids,
her
condition
deteriorated,
resulting
dyspnea
cardiogenic
shock
2020.
In
May
2023,
was
initiated
as
an
adjuvant
treatment.
The
received
daily
capsules,
led
increased
CD127+
Treg
cells,
reduced
anti-Ro
antibodies,
decreased
B
cell
subsets.
Her
clinical
symptoms
stabilized
without
adverse
effects.
Conclusion:
highlights
potential
benefits
H2
exhibiting
anti-inflammatory
immunomodulatory
effects,
leading
improved
immune
profiles
stabilizing
unresponsive
conventional
treatments.
Further
research
needed
elucidate
mechanisms
validate
its
larger
cohorts.
Molecular
shows
promise
safe
adjunctive
offering
new
approach
managing
this
challenging
condition.
Язык: Английский
Molecular Hydrogen as a Potential Adjunctive Therapy to Improve Renal Function and Reduce Fatigue in an Elderly Patient With Chronic Comorbidities: A Case Report
In Vivo,
Год журнала:
2024,
Номер
39(1), С. 572 - 576
Опубликована: Дек. 31, 2024
Hydrogen
therapy
has
demonstrated
potential
as
an
antioxidant
and
anti-inflammatory
intervention,
particularly
in
the
management
of
chronic
diseases
such
kidney
disease
(CKD)
autoimmune
conditions.
This
case
report
presents
possible
therapeutic
benefits
molecular
hydrogen
capsule
treatment
enhancing
renal
function
alleviating
fatigue
elderly
female
with
coronary
artery
(CAD),
type
2
diabetes
mellitus
(DM)
complicated
by
nephropathy,
systemic
lupus
erythematosus
(SLE).
The
aim
this
study
was
to
investigate
efficacy
adjunctive
patient
multiple
comorbidities.
Язык: Английский
Precision Assessment of Anti-NMDA Receptor Encephalitis: A Case Report on Integrating Clinical Course, Immunophenotyping, and Comprehensive Symptomatology in a Pediatric Patient With Adjunctive Hydrogen Therapy
In Vivo,
Год журнала:
2024,
Номер
39(1), С. 539 - 547
Опубликована: Дек. 31, 2024
Anti-N-methyl-D-aspartate
receptor
(NMDAR)
encephalitis,
though
rare,
is
the
most
common
form
of
autoimmune
predominantly
affecting
young
individuals,
particularly
females.
Standard
treatments
include
corticosteroids,
intravenous
immunoglobulins
(IVIG),
and
plasmapheresis,
with
rituximab
recommended
for
those
unresponsive
to
first-line
therapies.
However,
reliable
biomarkers
clinical
assessment
remain
elusive.
This
study
investigated
efficacy
adjunctive
hydrogen
therapy
in
a
patient
anti-NMDAR
encephalitis.
Язык: Английский