Environmental Pollution, Год журнала: 2024, Номер unknown, С. 125440 - 125440
Опубликована: Дек. 1, 2024
Язык: Английский
Neurological Sciences, Год журнала: 2025, Номер unknown
Опубликована: Фев. 19, 2025
Язык: Английский
Процитировано
2
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 21, 2025
Abstract Recent advancements in microRNAs (miRNAs) research have revealed their key roles both normal physiological processes and pathological conditions, leading to potential applications diagnostics therapeutics. However, the path forward is fraught with several scientific technical challenges. This review article briefly explores milestones of discovery, biogenesis, functions, application for clinical diagnostic therapeutic strategies miRNAs. The challenges future directions are also discussed fully harness capabilities.
Язык: Английский
Процитировано
1
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 7, 2025
Язык: Английский
Процитировано
1
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Abstract Bisphenol A (BPA) is an “environmental obesogen” and this study aims to investigate the intergenerational impacts of BPA‐induced metabolic syndrome (MetS), specifically focusing on unraveling mechanisms. Exposure BPA induces disorders in paternal mice, which are then transmitted offspring, leading late‐onset MetS. Mechanistically, upregulates Srebf1, turn promotes Pparg‐dependent transcription Dicer1 spermatocytes, increasing levels multiple sperm microRNAs (miRNAs). Several these miRNAs highly expressed a synchronized manner liver offspring. miR149‐5p, miR150‐5p, miR700‐5p target specific region Lepr 3′UTR, termed “SMITE” (“ S everal Mi RNAs T argeting E lements”), negatively regulate Lepr. These i nherited nti‐ L epr miRNAs, also referred (IAL‐miRs), modulate hepatic steatosis, insulin signaling through regulatory Igfbp2, Egfr, Ampk. Furthermore, IAL‐miRs inhibit Ccnd1 not only via binding but Lepr–Igfbp2 axis, contribute hepatocyte senescence. pathological processes interact self‐reinforcing cycle, worsening MetS BPA‐exposed The findings reveal mechanism wherein lipid metabolism reprogramming spermatocytes‐induced perturbations triggered by BPA, leads inheritance suppression axis
Язык: Английский
Процитировано
0
Genes, Год журнала: 2025, Номер 16(3), С. 262 - 262
Опубликована: Фев. 24, 2025
A large fraction of the human genome is transcribed in RNA molecules that do not encode for proteins but have a crucial role regulating almost every level gene expression and, thus, define specific phenotype each cell. These non-coding RNAs include well-characterized microRNAs and thousands less-defined longer transcripts, named long RNAs. Both types markedly affect onset progression numerous pathologies, ranging from cancer to vascular neuro-degenerative diseases. In recent years, substantial effort has been made design drugs targeting ncRNAs, promising advancements produced micro-RNA mimics inhibitors. Each ncRNA controls several targets, overall effect its inhibition or overexpression depends on function set genes it regulates. Therefore, selecting most appropriate target, predicting final outcome ncRNA-based therapies, utilize detailed accurate knowledge their functional interactions. this review, I recapitulate principal resources which collect information microRNA lncRNA networks, focusing non-homogeneity data result disparate approaches. highlight identifiers interaction evidence standardization helping user filter integrate derived different databases reliable web regulative relations.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161121 - 161121
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Analytical Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 9, 2025
Early and precise diagnosis of neurodegenerative disorders like Alzheimer's (AD) Parkinson's (PD) is crucial for slowing their progression enhancing patient outcomes. Exosomal microRNAs (miRNAs) are emerging as promising biomarkers due to ability reflect the diseases' pathology, yet low abundance poses significant detection hurdles. This review article delves into burgeoning field electrochemical biosensors, designed exosomal miRNA biomarkers. Electrochemical biosensors offer a compelling solution, combining sensitivity required detect low-abundance with specificity needed discern profiles distinctive neural pathological states. We explore operational principles these including transduction mechanisms that facilitate detection. The also summarizes advancements in nanotechnology, signal enhancement, bioreceptor anchoring, microfluidic integration improve sensor accuracy. evidence use disease analyzed, focusing on clinical impact, diagnostic precision, obstacles faced practical applications. Their potential point-of-care testing regulatory considerations market entry discussed. Looking toward future, highlights forthcoming innovations might revolutionize early processes. impressive sensitivity, specificity, compatibility, track become instrumental diseases, possibly transforming care prognosis.
Язык: Английский
Процитировано
0
TrAC Trends in Analytical Chemistry, Год журнала: 2025, Номер 185, С. 118173 - 118173
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
0
Food Chemistry, Год журнала: 2024, Номер 461, С. 140834 - 140834
Опубликована: Авг. 12, 2024
Язык: Английский
Процитировано
3
Biomedical Journal, Год журнала: 2024, Номер unknown, С. 100769 - 100769
Опубликована: Июль 1, 2024
• The first comprehensive summarization of miRNA profiles from stool samples. Fecal miRNAs show promise as reliable biomarkers for early detection CRC. have particular advantages integration into FIT-guided CRC screening.
Язык: Английский
Процитировано
2