Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 1443 - 1490
Опубликована: Фев. 1, 2025
Abstract:
Given
the
complexity
of
central
nervous
system
(CNS)
and
diversity
neurological
conditions,
increasing
prevalence
disorders
poses
a
significant
challenge
to
modern
medicine.
These
disorders,
ranging
from
neurodegenerative
diseases
psychiatric
not
only
impact
individuals
but
also
place
substantial
burden
on
healthcare
systems
society.
A
major
obstacle
in
treating
these
conditions
is
blood-brain
barrier
(BBB),
which
restricts
passage
therapeutic
agents
brain.
Nanotechnology,
particularly
use
nanoparticles
(NPs),
offers
promising
solution
this
challenge.
NPs
possess
unique
properties
such
as
small
size,
large
surface
area,
modifiable
characteristics,
enabling
them
cross
BBB
deliver
drugs
directly
affected
brain
regions.
This
review
focuses
application
gene
therapy
enzyme
replacement
(ERT)
for
disorders.
Gene
involves
altering
or
manipulating
expression
can
be
enhanced
by
designed
carry
various
genetic
materials.
Similarly,
improve
efficacy
ERT
lysosomal
storage
(LSDs)
facilitating
delivery
brain,
overcoming
issues
like
immunogenicity
instability.
Taken
together,
explores
potential
revolutionizing
treatment
options
highlighting
their
advantages
future
directions
rapidly
evolving
field.
Keywords:
system,
nanoparticle,
therapy,
Язык: Английский
Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 6, 2025
Neutrophil
extracellular
traps
(NETs)
participate
in
both
host
defense
and
the
pathogenesis
of
various
diseases,
such
as
infections,
thrombosis,
tumors.
While
they
help
capture
eliminate
pathogens,
NETs'
excessive
or
dysregulated
formation
can
lead
to
tissue
damage
disease
progression.
Therapeutic
strategies
targeting
NET
modulation
have
shown
potential,
but
challenges
remain,
particularly
achieving
precise
drug
delivery
maintaining
stability.
Nanoparticle
(NP)-based
systems
offer
innovative
solutions
for
overcoming
limitations
conventional
therapies.
This
review
explores
biological
mechanisms
formation,
their
interactions
with
NPs,
therapeutic
applications
NP-based
modulating
NETs.
We
discuss
how
NPs
be
designed
either
promote
inhibit
provide
a
comprehensive
analysis
potential
treating
NET-related
diseases.
Additionally,
we
address
current
future
prospects
therapies
research,
aiming
bridge
gap
between
nanotechnology
development
novel
approaches.
Язык: Английский