Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 2, 2025
The
intricate
interaction
between
skeletal
muscle
biomechanics,
the
tumor
microenvironment,
and
immunotherapy
constitutes
a
pivotal
research
focus
oncology.
This
work
provides
comprehensive
review
of
methodologies
for
evaluating
including
handheld
dynamometry,
advanced
imaging
techniques,
electrical
impedance
myography,
elastography,
single-fiber
experiments
to
assess
quality
performance.
Furthermore,
it
elucidates
mechanisms,
applications,
limitations
various
modalities,
immune
checkpoint
inhibitors,
adoptive
cell
therapy,
cancer
vaccines,
combined
chemoimmunotherapy,
while
examining
their
effects
on
function
systemic
responses.
Key
findings
indicate
that
although
is
effective
in
augmenting
antitumor
immunity,
frequently
induces
muscle-related
adverse
such
as
weakness,
fatigue,
or
damage,
primarily
mediated
by
cytokine
release
activation.
underscores
significance
niches
within
microenvironment
influencing
treatment
outcomes
proposes
strategies
optimize
therapy
through
personalized
regimens
combinatorial
approaches.
highlights
need
further
formation
interactions
muscle-tumor.
Our
crucial
advancing
efficacy
immunotherapy,
reducing
effects,
ultimately
improving
survival
rates
life
patients
with
cancer.
Antioxidants,
Год журнала:
2025,
Номер
14(1), С. 72 - 72
Опубликована: Янв. 9, 2025
Type
2
diabetes
mellitus
(T2DM)
is
a
chronic
metabolic
disorder
that
significantly
increases
the
risk
of
cardiovascular
disease,
which
leading
cause
morbidity
and
mortality
among
diabetic
patients.
A
central
pathophysiological
mechanism
linking
T2DM
to
complications
oxidative
stress,
defined
as
an
imbalance
between
reactive
oxygen
species
(ROS)
production
body’s
antioxidant
defenses.
Hyperglycemia
in
promotes
stress
through
various
pathways,
including
formation
advanced
glycation
end
products,
activation
protein
kinase
C,
mitochondrial
dysfunction,
polyol
pathway.
These
processes
enhance
ROS
generation,
endothelial
vascular
inflammation,
exacerbation
damage.
Additionally,
disrupts
nitric
oxide
signaling,
impairing
vasodilation
promoting
vasoconstriction,
contributes
complications.
This
review
explores
molecular
mechanisms
by
pathogenesis
disease
T2DM.
It
also
examines
potential
lifestyle
modifications,
such
dietary
changes
physical
activity,
reducing
mitigating
risks
this
high-risk
population.
Understanding
these
critical
for
developing
targeted
therapeutic
strategies
improve
outcomes
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(1), С. 380 - 380
Опубликована: Янв. 4, 2025
Plant
secondary
metabolites
(PSMs)
are
a
diverse
group
of
bioactive
compounds,
including
flavonoids,
polyphenols,
saponins,
and
terpenoids,
which
have
been
recognised
for
their
critical
role
in
modulating
cellular
functions.
This
review
provides
comprehensive
analysis
the
effects
PSMs
on
mitochondrial
health,
with
particular
emphasis
therapeutic
potential.
Emerging
evidence
shows
that
these
improve
function
by
reducing
oxidative
stress,
promoting
biogenesis,
regulating
key
processes
such
as
apoptosis
mitophagy.
Mitochondrial
dysfunction,
hallmark
many
pathologies,
neurodegenerative
disorders,
cardiovascular
diseases,
metabolic
syndrome,
has
shown
to
benefit
from
protective
PSMs.
Recent
studies
show
can
dynamics,
stabilise
membranes,
enhance
bioenergetics,
offering
significant
promise
prevention
treatment
mitochondrial-related
diseases.
The
molecular
mechanisms
underlying
effects,
modulation
signalling
pathways
direct
interactions
proteins,
discussed.
integration
into
strategies
is
highlighted
promising
avenue
improving
efficacy
while
minimising
side
commonly
associated
synthetic
drugs.
also
highlights
need
future
research
elucidate
specific
roles
individual
synergistic
within
complex
plant
matrices,
may
further
optimise
utility.
Overall,
this
work
valuable
insights
health
potential
natural
agents
targeting
dysfunction.
Free Radical Research,
Год журнала:
2025,
Номер
unknown, С. 1 - 25
Опубликована: Янв. 7, 2025
Free
radicals
have
been
implicated
in
the
pathogenesis
of
cancer
along
with
cardiovascular,
neurodegenerative,
pulmonary
and
inflammatory
disorders.
Further,
relationship
between
oxidative
stress
disease
is
distinctively
established.
Clinical
trials
using
anti-oxidants
for
prevention
progression
indicated
some
beneficial
effects.
However,
these
failed
to
establish
as
therapeutic
agents
due
lack
efficacy.
This
attributed
fact
that
living
systems
are
under
dynamic
redox
control
wherein
their
behaviour
compartmentalized
simple
aggregation
couples,
distributed
throughout
system,
miniscule
importance
while
determining
overall
state.
free
radical
metabolism
intriguingly
complex
they
play
plural
roles
segregated
a
spatio-temporal
manner.
Depending
on
quality,
quantity
site
generation,
exhibit
or
harmful
Use
non-specific,
non-targeted,
general
ROS
scavengers
lead
systemic
elimination
all
types
interferes
cellular
signaling.
Failure
act
lies
this
oversimplification
extremely
environment
static
non-compartmentalized
Rather
than
generalizing
term
"oxidative
stress"
if
we
can
identify
"type
different
diseases,
targeted
more
specific
anti-oxidant
therapy
may
be
developed.
In
review,
discuss
concept
dynamics,
role
type
conditions,
current
status
agents.
probe
possibility
developing
novel,
efficacious
drug-like
properties.
BIO Web of Conferences,
Год журнала:
2025,
Номер
154, С. 02007 - 02007
Опубликована: Янв. 1, 2025
Rhodamine
B
is
a
carcinogenic
additive
that
can
trigger
free
radicals.
Bajakah
wood
(
Spatholobus
littoralis
),
red
betel
Piper
crocatum
and
Papua
fruit
Pandanus
conoideus
)
are
herbs
with
high
antioxidants
to
ward
off
This
study
analyzed
the
ability
of
three
fight
radicals
due
rhodamine
injection.
Eighty-five
mice
Mus
musculus
were
divided
into
17
treatment
groups.
The
groups
consisted
without
B,
only
combination
certain
herbal
doses.
Free
radical
measurements
carried
out
using
Electron
Spin
Resonance
(ESR),
cell
damage
was
observed
through
histopathology.
effective
doses
7.27
mg/ml
(Bajakah),
3.95
(red
betel),
8.83
(Papua
fruit).
decreased
0.6
A.u
0.8
0.7
Histopathology
showed
decrease
in
by
44.7%
30.2%
26.6%
results
correlate
damage.
most
herb
for
preventing
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 757 - 757
Опубликована: Янв. 17, 2025
Pompe
disease
is
a
neuromuscular
disorder
caused
by
deficiency
of
the
enzyme
acid
alpha-glucosidase
(GAA),
which
leads
to
lysosomal
glycogen
accumulation
and
progressive
development
muscle
weakness.
Two
distinct
isoforms
have
been
identified.
In
infantile
form,
weakness
often
severe
motor
difficulties
from
first
few
months
life.
adult
patients,
progression
slower
but
can
still
lead
significant
loss
mobility.
The
current
inherent
lie
in
both
early
diagnosis
use
biomarkers.
Given
that
this
multifactorial
disease,
number
components
may
exert
an
influence
on
process;
degree
pre-ERT
(enzyme
replacement
therapy)
damage
damaged
autophagic
system
different
pathways
involved.
What
methodology
should
be
employed
study
complex
characteristics
disease?
Our
approach
relies
application
genetic
epigenetic
knowledge,
with
proteomics
transcriptomics.
It
also
becoming
increasingly
evident
artificial
intelligence
area
interest.
objective
conduct
comprehensive
review
existing
literature
known
data
complications
associated
patients
disorders
attributed
disease.
