Biotechnology & Biotechnological Equipment, Год журнала: 2024, Номер 38(1)
Опубликована: Ноя. 12, 2024
Lysine succinylation is a post-translational modification that occurs when succinyl group bonds with lysine residue and changes the polarity of from positive to negative, causing significant in structure functioning proteins. on various proteins crucial cellular biological processes eukaryotic prokaryotic organisms. Succinylation site identification an area high research interest, sequence-based prediction methods using machine learning deep have been developed based experimentally confirmed data sites, aiming be highly accurate, robust, quick, cost-efficient. However, despite usefulness these methods, different issues must addressed building model succinylation. As predictors become more abundant, it assess their advantages drawbacks identify potential improve efficiency predicting sites. Among multiple studies employed machine-learning deep-learning applications, few systematically examined computational issues. Hence, this review, we summarize challenges restrictions development models provide guidelines for suitable efficient methods.
Язык: Английский