Characterizing tumor biology and immune microenvironment in high-grade serous ovarian cancer via single-cell RNA sequencing: insights for targeted and personalized immunotherapy strategies
Frontiers in Immunology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 17, 2025
High-grade
serous
ovarian
cancer
(HGSOC),
the
predominant
subtype
of
epithelial
cancer,
is
frequently
diagnosed
at
an
advanced
stage
due
to
its
nonspecific
early
symptoms.
Despite
standard
treatments,
including
cytoreductive
surgery
and
platinum-based
chemotherapy,
significant
improvements
in
survival
have
been
limited.
Understanding
molecular
mechanisms,
immune
landscape,
drug
sensitivity
HGSOC
crucial
for
developing
more
effective
personalized
therapies.
This
study
integrates
insights
from
immunology,
profiling,
analysis
identify
novel
therapeutic
targets
improve
treatment
outcomes.
Utilizing
single-cell
RNA
sequencing
(scRNA-seq),
systematically
examines
tumor
heterogeneity
microenvironment,
focusing
on
biomarkers
influencing
response
activity,
aiming
enhance
patient
outcomes
quality
life.
scRNA-seq
data
was
obtained
GEO
database
this
study.
Differential
gene
expression
analyzed
using
ontology
set
enrichment
methods.
InferCNV
identified
malignant
cells,
while
Monocle,
Cytotrace,
Slingshot
software
inferred
differentiation
trajectories.
The
CellChat
package
predicted
cellular
communication
between
cell
subtypes
other
pySCENIC
utilized
transcription
factor
regulatory
networks
within
subtypes.
Finally,
results
were
validated
through
functional
experiments,
a
prognostic
model
developed
assess
prognosis,
infiltration,
across
various
risk
groups.
investigated
scRNA-seq,
their
interactions
microenvironment.
We
confirmed
key
role
C2
IGF2+
HGSOC,
which
significantly
associated
with
poor
prognosis
high
levels
chromosomal
copy
number
variations.
located
terminal
tumor,
displaying
higher
degree
malignancy
close
association
IIIC
tissue
types.
also
metabolic
pathways,
such
as
glycolysis
riboflavin
metabolism,
well
programmed
death
processes.
highlighted
complex
fibroblasts
MK
signaling
pathway,
may
be
closely
related
tumor-associated
progression.
Elevated
PRRX1
connected
impact
disease
progression
by
modulating
transcription.
A
based
demonstrated
adverse
outcomes,
emphasizing
importance
infiltration
clinical
intervention
strategies.
oncology,
immunotherapy,
reveal
mechanisms
driving
resistance.
subtype,
linked
offers
promising
target
future
Emphasizing
sensitivity,
research
highlights
strategies
life
patients.
Язык: Английский
The role of circular RNAs in glucose metabolic reprogramming: impact on cancer progression and therapeutic implications in breast cancer
Journal of Cancer Metastasis and Treatment,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Breast
cancer
is
one
of
the
most
common
female
malignant
tumors,
which
seriously
endangers
human
health.
Glucose
metabolic
reprogramming
in
rapidly
proliferating
cancers
drives
increased
glycolysis
to
meet
energy
needs,
promoting
tumor
growth,
acidifying
microenvironment,
and
impairing
immune
function,
diminishes
therapeutic
efficacy.
Circular
RNAs
(circRNAs),
as
key
regulators
cellular
processes,
are
increasingly
recognized
for
their
involvement
cancer.
Concurrently,
specific
circRNAs
could
be
released
by
cells
via
exosomes
facilitate
intercellular
communication,
significantly
impacting
glucose
metabolism,
progression,
therapy
resistance.
However,
role
breast
mechanisms
regulating
metabolism
remain
unclear.
Therefore,
elucidating
these
regulatory
pathways
provide
valuable
insights
developing
targeted
strategies
exploit
vulnerabilities
improve
prognosis
Язык: Английский
Recent advances in the role of high-salt diet in anti- and pro-cancer progression
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 29, 2025
Dietary
behaviors
significantly
influence
tumor
progression,
with
increasing
focus
on
high-salt
diets
(HSD)
in
recent
years.
Traditionally,
HSD
has
been
regarded
as
a
major
risk
factor
for
multiple
health
issues,
including
hypertension,
cardiovascular
disease,
kidney
cancer,
and
osteoporosis.
However,
studies
have
uncovered
novel
aspect
of
HSD,
suggesting
that
may
inhibit
growth
specific
pathological
conditions
by
modulating
the
activity
immune
cells
infiltrate
tumors
enhancing
effectiveness
PD-1
immunotherapy.
This
review
focused
duel
molecular
mechanisms
cancer
development,
which
are
based
microenvironment,
gut
microbiota,
involvement
sodium
transporter
channels.
The
objective
this
is
to
explore
whether
could
be
potential
future
oncological
therapeutic
strategy
under
situation.
Язык: Английский
MR Imaging Techniques for Microenvironment Mapping of the Glioma Tumors: A Systematic Review
Academic Radiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
PKN2 enhances the immunosuppressive activity of polymorphonuclear myeloid-derived suppressor cells in esophageal carcinoma by mediating fatty acid oxidation
Molecular Medicine,
Год журнала:
2025,
Номер
31(1)
Опубликована: Март 11, 2025
Abstract
Background
Myeloid-derived
suppressor
cells
(MDSCs)
in
tumor
microenvironment
reduce
the
efficacy
of
immunotherapy.
PKN2
plays
a
role
colon
cancer,
but
its
function
esophageal
cancer
(EC)
remains
unclear.
This
study
investigated
expression
MDSCs
derived
from
EC
tissues
and
determined
whether
regulates
immunosuppressive
activity
by
mediating
fatty
acid
oxidation
(FAO).
Materials
methods
was
GEO
database,
patients,
4-NQO-induced
mice,
as
well
different
types
immune
cells.
The
effect
on
polymorphonuclear
myeloid-derived
(PMN-MDSCs)
co-culture
PMN-MDSCs
CD4
+
/CD8
T
patient-derived
organoids
autologous
performed
to
observe
PMN-MDSCs.
Results
is
highly
expressed
compared
normal
tissues,
especially
tumor-infiltrated
Overexpressing
contributes
vitro.
PKN2-overexpressing
inhibited
killing
ability
cytotoxic
lymphocytes
promoted
organoid
growth.
promotes
FAO
via
CPT1B
(a
key
enzyme
FAO).
Mechanistically,
transcription
upregulating
STAT3
phosphorylation.
Conclusions
increased
human
mouse
tissues.
enhancing
facilitating
phosphorylation
transcription,
which
turn
leads
CPT1B-mediated
Targeted
inhibition
expected
improve
immunotherapeutic
patients.
Язык: Английский
Global research trends and focus on immunotherapy for endometrial cancer: a comprehensive bibliometric insight and visualization analysis (2012-2024)
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 8, 2025
This
study
conducted
a
novel
systematic
bibliometric
and
visualization
analysis
of
global
literature
on
immunotherapy
for
endometrial
cancer
(EC)
to
explore
dynamic
trends,
research
hotspots,
emerging
topics,
providing
valuable
references
future
research.
Articles
reviews
EC
published
between
2012
August
2024
were
retrieved
from
the
Web
Science
Core
Collection
(WoSCC).
Bibliometric
tools,
CiteSpace
VOSviewer,
used
analyze
clustering
patterns
dynamics.
A
total
861
articles
contributed
by
5,331
authors
1,392
institutions
across
58
countries
or
regions,
involving
1,823
keywords.
China
demonstrated
outstanding
performance
in
this
field,
contributing
over
40%
publications
ranking
first
publication
volume.
However,
citation
counts
lags
that
United
States,
highlighting
latter's
leading
position
areas
further
improvement
China's
efforts.
The
University
Texas
Medical
Anderson
Cancer
Center
Nanjing
two
with
highest
number
publications.
In
terms
authorship,
teams
led
Bosse,
Tjalling,
Creutzberg,
Carien
L
made
significant
contributions
advancing
field.
Among
individual
publications,
work
Talhouk
et
al.
achieved
average
annual
count
70.88,
demonstrating
its
profound
impact.
journals,
Gynecologic
Oncology
emerged
as
pivotal
academic
platform,
publishing
numerous
achieving
co-citation
frequency.
Additionally,
Frontiers
Oncology,
Immunology,
Genetics
have
become
some
most
active
rapidly
developing
journals
recent
years.
Research
hotspots
are
concentrated
themes
such
"Tumor
Immune
Microenvironment",
"Immune
Checkpoint
Inhibitors",
"Targeted
Therapy".
Recent
trends
frontier
focus
combined
application
immune
checkpoint
inhibitors
other
therapies,
nanotechnology
immunotherapy,
integration
artificial
intelligence
enhance
precision
medicine.
efforts
increasingly
directed
toward
various
strategies
basic
clinical
applications.
comprehensive
reveals
rapid
advancements
potential
immunotherapy.
Strengthening
international
collaboration
addressing
barriers
translation
practice
will
drive
progress
promising
Язык: Английский
Coptidis Rhizoma and Berberine as Anti-cancer Drugs: a 10-year updates and future perspectives
Pharmacological Research,
Год журнала:
2025,
Номер
unknown, С. 107742 - 107742
Опубликована: Апрель 1, 2025
Cancer
continues
to
be
among
the
most
substantial
health
challenges
globally.
Among
various
natural
compounds,
berberine,
an
isoquinoline
alkaloid
obtained
from
Coptidis
Rhizoma,
has
garnered
considerable
attention
for
its
broad-spectrum
biological
activities,
including
anti-inflammatory,
antioxidant,
anti-diabetic,
anti-obesity,
and
anti-microbial
activities.
Furthermore,
berberine
exhibits
a
broad
spectrum
of
anti-cancer
efficacy
against
malignancies,
such
as
ovarian,
breast,
lung,
gastric,
hepatic,
colorectal,
cervical,
prostate
cancers.
Its
mechanisms
are
multifaceted,
encompassing
inhibition
cancer
cell
proliferation,
prevention
metastasis,
induction
apoptosis,
facilitation
autophagy,
modulation
tumor
microenvironment
gut
microbiota,
enhancement
conventional
therapeutic
strategies.
This
paper
offers
exhaustive
overview
cancer-fighting
characteristics
Rhizoma
while
also
exploring
recent
developments
in
nanotechnology
aimed
at
enhancing
bioavailability
berberine.
side
effects
safety
addressed
well.
The
potential
role
artificial
intelligence
optimizing
berberine's
applications
is
highlighted.
provides
precious
perspectives
on
prospective
application
management
cancer.
Язык: Английский
Synthesis, biological evaluation and mechanism study of a novel indole-pyridine chalcone derivative as antiproliferative agent against tumor cells through dual targeting tubulin and HK2
European Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
282, С. 117058 - 117058
Опубликована: Ноя. 16, 2024
Язык: Английский
Investigating the regulatory mechanism of glucose metabolism by ubiquitin-like protein MNSFβ
Molecular Biology Reports,
Год журнала:
2024,
Номер
51(1)
Опубликована: Окт. 15, 2024
Язык: Английский
Targeting PGK1: A New Frontier in Breast Cancer Therapy Under Hypoxic Conditions
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(11), С. 12214 - 12229
Опубликована: Окт. 30, 2024
Breast
cancer
represents
one
of
the
most
prevalent
malignant
neoplasms
affecting
women,
and
its
pathogenesis
has
garnered
significant
scholarly
interest.
Research
indicates
that
progression
breast
is
intricately
regulated
by
glucose
metabolism.
Under
hypoxic
conditions
within
tumor
microenvironment,
cells
generate
ATP
essential
biosynthetic
precursors
for
growth
via
glycolytic
pathway.
Notably,
phosphoglycerate
kinase
1
(PGK1)
intimately
associated
with
regulation
hypoxia-inducible
factors
in
plays
a
crucial
role
modulating
processes.
Further
investigation
into
PGK1
anticipated
to
identify
novel
therapeutic
targets
strategies.
This
review
consolidates
current
research
on
metabolism
function
conditions.
It
aims
offer
theoretical
foundation
elucidating
mechanisms
underlying
metastasis,
thereby
facilitating
development
innovative
treatment
approaches.
Язык: Английский