Acupuncture alleviates hemorrhagic transformation after delayed rt-PA treatment for acute ischemic stroke by regulating the mitophagy-NLRP3 inflammasome pathway DOI Creative Commons
Tao Jiang,

Qianqian Liu,

Huanhuan Liu

и другие.

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Апрель 7, 2025

The clinical application of recombinant tissue plasminogen activator (rt-PA) is significantly constrained by hemorrhagic transformation (HT), a common and severe complication following thrombolysis for ischemic stroke. Notably, the mitochondrial injury-mediated NLRP3 inflammasome plays crucial role in HT after delayed rt-PA acute Although acupuncture has demonstrated antioxidant anti-inflammatory effects cerebral infarction, its impact on thrombolysis, especially concerning mitophagy inflammasome, remains unclear. This study investigates how protects against resulting from damage activation We selected an embolic stroke model rats assessed brain injury using neurological deficit score, volume infarct, permeability assay blood-brain barrier (BBB), HT. Then, levels proteins mRNA involved pathway were measured western blot real-time PCR. interleukin-18 (IL-18) interleukin-1β (IL-1β) enzyme-linked immunosorbent (ELISA). Morphological changes BBB mitochondria neurons observed via transmission electron microscopy. Acupuncture improved scores, destruction, rat. Furthermore, induced substantially downregulated activity inflammasome. Additionally, use inhibitors reversed suppressive can promote suppress to decrease therapy

Язык: Английский

Activation of α7nAch receptors ameliorates α-synuclein pathology in the brain and gut of a subacute MPTP mouse model of Parkinson's disease DOI Open Access

Yea‐Hyun Leem,

Jung‐Eun Park,

Jin‐Sun Park

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 184, С. 117871 - 117871

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Acupuncture alleviates hemorrhagic transformation after delayed rt-PA treatment for acute ischemic stroke by regulating the mitophagy-NLRP3 inflammasome pathway DOI Creative Commons
Tao Jiang,

Qianqian Liu,

Huanhuan Liu

и другие.

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Апрель 7, 2025

The clinical application of recombinant tissue plasminogen activator (rt-PA) is significantly constrained by hemorrhagic transformation (HT), a common and severe complication following thrombolysis for ischemic stroke. Notably, the mitochondrial injury-mediated NLRP3 inflammasome plays crucial role in HT after delayed rt-PA acute Although acupuncture has demonstrated antioxidant anti-inflammatory effects cerebral infarction, its impact on thrombolysis, especially concerning mitophagy inflammasome, remains unclear. This study investigates how protects against resulting from damage activation We selected an embolic stroke model rats assessed brain injury using neurological deficit score, volume infarct, permeability assay blood-brain barrier (BBB), HT. Then, levels proteins mRNA involved pathway were measured western blot real-time PCR. interleukin-18 (IL-18) interleukin-1β (IL-1β) enzyme-linked immunosorbent (ELISA). Morphological changes BBB mitochondria neurons observed via transmission electron microscopy. Acupuncture improved scores, destruction, rat. Furthermore, induced substantially downregulated activity inflammasome. Additionally, use inhibitors reversed suppressive can promote suppress to decrease therapy

Язык: Английский

Процитировано

0