Evaluation of chloramphenicol derivative N-phenyl 2, 2 dichloroacetamide anticancer and antibacterial properties
Therapeutic Delivery,
Год журнала:
2025,
Номер
unknown, С. 1 - 15
Опубликована: Март 10, 2025
Aims
This
study
aimed
to
develop
microparticles
of
N-phenyl-2,2-dichloroacetamide
(PDA),
a
chloramphenicol
derivative
with
potential
antibacterial
and
anticancer
properties,
improve
drug
release
selectivity
while
reducing
toxicity.
Язык: Английский
Diacerein's Antiproliferative Effects Alone and with 5-Fluorouracil in an Ehrlich Solid Tumour Model: Molecular Docking, Molecular Dynamics Simulation Studies, and Experimental Verification
European Journal of Pharmacology,
Год журнала:
2025,
Номер
unknown, С. 177564 - 177564
Опубликована: Март 1, 2025
Язык: Английский
Formation and evaluation of doxorubicin and cromoglycate metal–organic framework for anti-cancer activity
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 13
Опубликована: Янв. 31, 2025
We
develop
and
evaluate
copper-based
metal-organic
frameworks
(Cu-MOFs)
incorporating
cromolyn
as
a
linker
to
enhance
structural
stability,
drug
delivery
efficiency,
therapeutic
potential,
particularly
for
breast
cancer
treatment.
Two
Cu-MOF
formulations
were
synthesized:
Cu-MOFs-BDC-DOX
(using
terephthalic
acid)
Cu-MOFs-CROMO-DOX
linker).
Characterization
was
performed
using
SEM/TEM
morphology,
FTIR,
XRD,
TGA
confirm
integrity.
Drug
encapsulation
efficiency
release
profiles
assessed,
followed
by
in
vitro
cytotoxicity,
cell
migration,
colony
formation
assays
MDA-MB-231
cells.
Both
demonstrated
high
(83-91%)
sustained
over
48
h
at
pH
7.4.
exhibited
superior
cytotoxicity
with
an
IC50
of
0.88
±
0.07
µM
compared
7.1
0.11
Cu-MOFs-BDC-DOX.
inhibit
migration
dose-dependent
manner.
The
formulation
enhanced
outperforming
its
counterpart
targeting
This
study
highlights
the
promise
MOF-based
nanocarriers
overcoming
limitations
conventional
chemotherapy,
offering
pathway
more
effective
targeted
treatments
reduced
side
effects.
Язык: Английский
How Advanced are Self-Assembled Nanomaterials for Targeted Drug Delivery? A Comprehensive Review of the Literature
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 2133 - 2161
Опубликована: Фев. 1, 2025
The
development
of
effective
drug
delivery
systems
is
a
key
focus
in
pharmaceutical
research,
aiming
to
enhance
therapeutic
efficacy
while
minimizing
adverse
effects.
Self-assembled
nanostructures
present
promising
solution
due
their
tunable
properties,
biocompatibility,
and
ability
encapsulate
deliver
agents
specific
targets.
This
review
examines
recent
advancements
drug-based
self-assembled
for
targeted
applications,
including
drug-drug
conjugates,
polymeric-based
architectures,
biomolecules,
peptides,
DNA,
squalene
conjugates
amphiphilic
drugs.
Various
strategies
fabricating
these
are
discussed,
with
an
emphasis
on
the
design
principles
mechanisms
underlying
self-assembly
potential
tissues
or
cells.
Furthermore,
integration
targeting
ligands,
stimuli-responsive
moieties
imaging
into
explored
enhanced
outcomes
real-time
monitoring.
Challenges
such
as
stability,
scalability
regulatory
hurdles
translating
from
bench
bedside
also
addressed.
Drug-based
represent
platform
developing
next-generation
improved
reduced
side
Язык: Английский
Innovative Multitarget Organoselenium Hybrids With Apoptotic and Anti‐Inflammatory Properties Acting as JAK1/STAT3 Suppressors
Drug Development Research,
Год журнала:
2025,
Номер
86(2)
Опубликована: Март 18, 2025
ABSTRACT
Herein,
we
report
the
design,
synthesis,
and
characterization
of
novel
organoselenium
(OSe)
hybrids
(
5
–
19
)
via
modifications
lead,
N
‐(4‐selaneylphenyl)‐2‐selaneylacetamide.
The
OSe‐based
thiazol
9
showed
highest
growth
inhibition
%
(GI%)
64.72%
relative
to
positive
reference
doxorubicin
(DOX),
with
a
GI%
79.5%.
Furthermore,
OSe
derivatives
low
values
compared
normal
cell
lines
employed,
demonstrating
their
selectivity.
tethered
‐chloroacetamide
Schiff
base
cytotoxic
effect
an
IC
50
(25.07
11.61
µM),
respectively,
against
A549
tumor
line
(34.22
20.12
HELA
cancer
line.
Enzyme‐linked
immunosorbent
assay
study
JAK1
STAT3
inhibitory
potentials
compounds
in
cells
both
promising
activities
25.07
µM,
respectively.
Protein
expression
analysis
on
upregulation
P53,
BAX,
Caspases
3,
6,
8,
as
apoptotic
proteins.
However,
candidates
expressed
downregulation
antiapoptotic
proteins
(BCL2,
MMP2,
MMP9).
Moreover,
described
examined
inflammatory
proteins:
COX2,
IL‐6,
IL‐1β.
In
addition,
compound
potential
cycle
arrest
at
G0,
S,
G2‐M
layers,
increase
cellular
levels.
Finally,
molecular
docking
studies
most
toward
target
receptors,
binding
scores
interactions
exceeding
that
cocrystallized
inhibitor
JAK1.
Язык: Английский
Green synthesized Zingiber officinale -ZnO nanoparticles: anticancer efficacy against 3D breast cancer model
Future Science OA,
Год журнала:
2024,
Номер
10(1)
Опубликована: Ноя. 14, 2024
Methodology:
Physical
characterization
and
biological
activity
were
performed
against
2D,
3D
spheroids
MCF-7
cell
lines.
Язык: Английский