Synthesis and Characterization of pH-Responsive Sodium Alginate/Zein/γ- Alumina Nanocarriers for Targeted Curcumin Delivery in Lung Cancer DOI Creative Commons

Mohammad Najafi,

Davood Rabiei Faradonbeh,

Sakineh Hajebi

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 8, 2024

Abstract Stimulus-responsive drug delivery systems based on anticancer of curcumin constitute a promising strategy to overcome some challenges Lung cancer treatment. In the present study, pH-responsive nanocarriers were designed by sodium alginate (SA), zein, and γ-alumina (γ-Al2O3) as nanocarrier via W/O/W double emulsion technique facilitate targeted lung cells. The characterize physical interactions crystalline structure confirmed FTIR XRD, respectively. size drug-loaded nanocomposites was 218.6 nm with monodisperse particle distribution, having rod-like shape approved DLS analysis FE-SEM, Sensitivity samples pH studied using ultraviolet − visible spectroscopy. UV vis spectroscopy results display higher absorption intensities in acidic tumor conditions (pH 5.4) than physiological (7.4). method significantly enhanced loading entrapment efficiency compared other reported systems. Cytotoxicity cell death further analyzed MTT flow cytometry assays. These suggest that SA/zein/γ-Al2O3 nanocomposite is promise system for therapy.

Язык: Английский

Controlling stimulus sensitivity by tailoring nanoparticle core hydrophobicity DOI Creative Commons
Xiao Zhang, Bowen Zhao, Shiwei Fu

и другие.

Biomaterials Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This study introduces a novel and efficient approach for constructing stimulus-responsive polycarbonates with tunable stimulus sensitivity by tailoring nanoparticle core hydrophobicity.

Язык: Английский

Процитировано

0
Thermoresponsive Nanocarriers Transduced by Inorganic Nanoparticles: Design Considerations and Applications in Drug Delivery DOI Creative Commons
Anamarija Nikoletić, Mirela Maleković, Gül Kozalak

и другие.

Helvetica Chimica Acta, Год журнала: 2025, Номер unknown

Опубликована: Фев. 22, 2025

Abstract Thermoresponsive polymers, which undergo phase transitions within physiologically tolerated temperatures, are key to developing drug delivery systems (DDS) with precise spatial and temporal control, potentially addressing challenges associated the treatment of complex diseases. Inorganic nanoparticles unique optical, electronic, magnetic properties serve as efficient transducers, converting external stimuli into localized heat trigger thermoresponsive nanocarriers. This review explores design application nanocarriers transduced by inorganic DDS. Following a brief description temperature‐triggered transition polymers generation mechanisms nanoparticles, strategies integrate these components hybrid described. Examples demonstrating utility advanced DDS discussed, highlighting their potential for release alongside theranostic capabilities combining therapy imaging. Despite in design, synthesis, biological applications, polymer‐inorganic hybrids hold immense promise transforming biomedical innovations.

Язык: Английский

Процитировано

0
Synthesis and Characterization of pH-Responsive Sodium Alginate/Zein/γ- Alumina Nanocarriers for Targeted Curcumin Delivery in Lung Cancer DOI Creative Commons

Mohammad Najafi,

Davood Rabiei Faradonbeh,

Sakineh Hajebi

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 8, 2024

Abstract Stimulus-responsive drug delivery systems based on anticancer of curcumin constitute a promising strategy to overcome some challenges Lung cancer treatment. In the present study, pH-responsive nanocarriers were designed by sodium alginate (SA), zein, and γ-alumina (γ-Al2O3) as nanocarrier via W/O/W double emulsion technique facilitate targeted lung cells. The characterize physical interactions crystalline structure confirmed FTIR XRD, respectively. size drug-loaded nanocomposites was 218.6 nm with monodisperse particle distribution, having rod-like shape approved DLS analysis FE-SEM, Sensitivity samples pH studied using ultraviolet − visible spectroscopy. UV vis spectroscopy results display higher absorption intensities in acidic tumor conditions (pH 5.4) than physiological (7.4). method significantly enhanced loading entrapment efficiency compared other reported systems. Cytotoxicity cell death further analyzed MTT flow cytometry assays. These suggest that SA/zein/γ-Al2O3 nanocomposite is promise system for therapy.

Язык: Английский

Процитировано

0