Cold Exposure Therapy Enhances Single-Atom Nanozyme-Mediated Cancer Vaccine Therapy DOI
Jinjun Ye, Hongwei Wang,

Jingzhi Zheng

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

Single-atom nanozymes are highly effective in the preparation of tumor vaccines (TV) due to their superior peroxidase (POD) activity and excellent biocompatibility. However, immunosuppressive environment within tumors can diminish efficacy these vaccines. Cold exposure (CE) therapy, a noninvasive straightforward antitumor method, not only suppresses metabolism but also ameliorates milieu. In this study, we developed personalized TV using copper single-atom nanozyme (Cu SAZ) enhanced long-term by introducing CE. We initially synthesized Cu SAZ via high-temperature carbonization, which demonstrated robust POD photothermal characteristics. Upon 808 nm laser irradiation, generated reactive oxygen species (ROS) heat, inducing immunogenic cell death 4T1 breast cancer cells or CT26 colon facilitating production. our vivo prevention treatment model, noted that CE significantly boosted TV. The primary mechanism involves CE's ability lower ratio myeloid-derived suppressor (MDSCs), decrease glucose cells, increase proportions CD8+ T memory cells. Collectively, findings offer promising avenues for designing innovative systems.

Язык: Английский

Cold Exposure Therapy Enhances Single-Atom Nanozyme-Mediated Cancer Vaccine Therapy DOI
Jinjun Ye, Hongwei Wang,

Jingzhi Zheng

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

Single-atom nanozymes are highly effective in the preparation of tumor vaccines (TV) due to their superior peroxidase (POD) activity and excellent biocompatibility. However, immunosuppressive environment within tumors can diminish efficacy these vaccines. Cold exposure (CE) therapy, a noninvasive straightforward antitumor method, not only suppresses metabolism but also ameliorates milieu. In this study, we developed personalized TV using copper single-atom nanozyme (Cu SAZ) enhanced long-term by introducing CE. We initially synthesized Cu SAZ via high-temperature carbonization, which demonstrated robust POD photothermal characteristics. Upon 808 nm laser irradiation, generated reactive oxygen species (ROS) heat, inducing immunogenic cell death 4T1 breast cancer cells or CT26 colon facilitating production. our vivo prevention treatment model, noted that CE significantly boosted TV. The primary mechanism involves CE's ability lower ratio myeloid-derived suppressor (MDSCs), decrease glucose cells, increase proportions CD8+ T memory cells. Collectively, findings offer promising avenues for designing innovative systems.

Язык: Английский

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