Multi-Target Protective Effects of Sanghuangporus sanghuang Against 5-Fluorouracil-Induced Intestinal Injury Through Suppression of Inflammation, Oxidative Stress, Epitheli-Al-Mesenchymal Transition, and Tight Junction DOI Open Access
Jaung‐Geng Lin,

Yu-Wen Sun,

Wenliang Wu

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3444 - 3444

Опубликована: Апрель 7, 2025

Sanghuang (Sanghuangporus sanghuang, SS) is a medicinal fungus with multiple pharmacological effects, including antioxidant, anti-inflammatory, immune-boosting, and anti-cancer activities. 5-fluorouracil (5-FU) commonly used chemotherapeutic agent for the treatment of colorectal cancer. It primarily exerts its antitumor effect by inhibiting DNA RNA synthesis, leading to cell apoptosis. However, it frequently induces adverse effects These issues limit clinical application 5-FU. This research aims determine potential SS as therapeutic in reducing 5-FU-induced intestinal mucositis mouse model. The results indicated that 5-FU administration significantly increased diarrhea severity, reduced colon length, caused small villus atrophy, disrupted architecture, led insufficient crypt proliferation, resulted weight loss. also upregulated inflammatory responses, apoptosis, oxidative stress, epithelial-mesenchymal transition (EMT) pathways, integrity mucosal tight junction, while elevating pro-inflammatory cytokines antioxidant capacity. ameliorating alleviating impacts on mucosa. In conclusion, this investigation provides first evidence protective mucositis. findings suggest application, offering promising strategy chemotherapy improving quality life cancer patients.

Язык: Английский

Multi-Target Protective Effects of Sanghuangporus sanghuang Against 5-Fluorouracil-Induced Intestinal Injury Through Suppression of Inflammation, Oxidative Stress, Epitheli-Al-Mesenchymal Transition, and Tight Junction DOI Open Access
Jaung‐Geng Lin,

Yu-Wen Sun,

Wenliang Wu

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3444 - 3444

Опубликована: Апрель 7, 2025

Sanghuang (Sanghuangporus sanghuang, SS) is a medicinal fungus with multiple pharmacological effects, including antioxidant, anti-inflammatory, immune-boosting, and anti-cancer activities. 5-fluorouracil (5-FU) commonly used chemotherapeutic agent for the treatment of colorectal cancer. It primarily exerts its antitumor effect by inhibiting DNA RNA synthesis, leading to cell apoptosis. However, it frequently induces adverse effects These issues limit clinical application 5-FU. This research aims determine potential SS as therapeutic in reducing 5-FU-induced intestinal mucositis mouse model. The results indicated that 5-FU administration significantly increased diarrhea severity, reduced colon length, caused small villus atrophy, disrupted architecture, led insufficient crypt proliferation, resulted weight loss. also upregulated inflammatory responses, apoptosis, oxidative stress, epithelial-mesenchymal transition (EMT) pathways, integrity mucosal tight junction, while elevating pro-inflammatory cytokines antioxidant capacity. ameliorating alleviating impacts on mucosa. In conclusion, this investigation provides first evidence protective mucositis. findings suggest application, offering promising strategy chemotherapy improving quality life cancer patients.

Язык: Английский

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