Current topics in behavioral neurosciences, Год журнала: 2022, Номер unknown, С. 315 - 362
Опубликована: Янв. 1, 2022
Язык: Английский
Neuroglia, Год журнала: 2024, Номер 5(4), С. 410 - 444
Опубликована: Окт. 21, 2024
Microglia, the unique and motile immune cells of central nervous system (CNS), function as a security guard in maintaining CNS homeostasis, primarily through calcium signaling. The dynamics microglia control important functions such phagocytosis, cytokine release, migration. Calcium dysregulation has been linked to several disorders, like Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), ischemic stroke (IS). entering channels voltage-gated (VGCCs), store-operated entry (SOCE), transient receptor potential (TRP) is essential for microglial activation pro-inflammatory responses. Under pathological conditions, formation amyloid-β plaques AD, aggregation α-synuclein PD, oxidative stress MS, exacerbates neuroinflammation, mitochondrial dysfunction, neurodegeneration. Therapeutic strategies targeting signaling pathways, using channel blockers antioxidant interventions, show promise alleviating slowing down progression. This review summarizes underlying mechanisms therapeutic benefits restoring balance disorders.
Язык: Английский
Процитировано
10
Psychiatry Research Neuroimaging, Год журнала: 2025, Номер 349, С. 111981 - 111981
Опубликована: Март 7, 2025
Язык: Английский
Процитировано
0
Brain Research, Год журнала: 2025, Номер unknown, С. 149643 - 149643
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Cerebral Cortex, Год журнала: 2024, Номер 34(6)
Опубликована: Июнь 1, 2024
Abstract Brain structural abnormality has been observed in the prodromal and early stages of schizophrenia, but mechanism behind it is not clear. In this study, to explore association between cortical abnormalities, metabolite levels, inflammation levels clinical symptoms 51 drug-naive first-episode schizophrenia (FES) patients, ultra-high risk for psychosis (UHR), healthy controls (HC) were recruited. We estimated gray matter volume (GMV), thickness (CT), concentrations different metabolites, inflammatory marks among four groups (UHR converted [UHR-C], UHR unconverted [UHR-NC], FES, HC). UHR-C group had more CT right lateral occipital cortex medial orbito-frontal (rMOF), while a significant reduction fusiform was FES group. significantly higher concentration IL-6, IL-17 could predict IL-4 predictors rMOF. To conclude, reasonable speculate that increased related response, may participate some compensatory mechanism, might become exhaustive with progress disease due potential neurotoxic effects.
Язык: Английский
Процитировано
2
Communications Biology, Год журнала: 2024, Номер 7(1)
Опубликована: Дек. 19, 2024
Abstract Recent neuroimaging studies demonstrate a heterogeneity of timescales prevalent in the brain’s ongoing spontaneous activity, labeled intrinsic neural (INT). At same time, also reflect stimulus- or task-related activity. The relationship INT during activity with their involvement task states including behavior remains unclear. To address this question, we combined calcium imaging data spontaneously behaving mice and human electroencephalography (EEG) rest computational modeling. We obtained four primary findings: (i) distinct behavioral can be accurately predicted from INT, (ii) become longer compared to rest, (iii) change is correlated negatively variability (iv) mass modeling shows key role recurrent connections mediating rest-task INT. Extending current findings, our results show dynamic nature reflecting continuous through flexible modulation possibly mediated by connections.
Язык: Английский
Процитировано
2
Schizophrenia Bulletin, Год журнала: 2023, Номер 50(1), С. 69 - 77
Опубликована: Сен. 4, 2023
Abstract Background and Hypothesis Schizotypy provides a framework for understanding the developmental nature of psychotic disorders means identifying “at-risk” individuals early in lifespan. However, there is lack prospective longitudinal research examining relationship between schizotypy childhood later other mental disorders. We hypothesized that distinct profiles would be differentially associated with emerging adolescence. Study Design In large population cohort Australian young people (n = 26 837), we prospectively examined person-centered identified middle (age ~11 years) adolescent diagnoses ~13–18 across 7 types using multinomial logistic regression. Results Membership any 3 (true schizotypy, affective or introverted schizotypy) was an increased likelihood being diagnosed type disorder adolescence; effects were strongest true group (aOR 3.07, 95% CI 2.64, 3.57), followed by 1.94, 1.75, 2.15) 1.29, 1.13, 1.47) groups. Six measured (including disorders) at least 1 group. Conclusions important correlate however, it does not appear to specifically this age
Язык: Английский
Процитировано
4
Science Advances, Год журнала: 2024, Номер 10(38)
Опубликована: Сен. 18, 2024
Frontal cortical circuits undergo prolonged maturation across childhood and adolescence; however, it remains unknown what specific changes are occurring at the circuit level to establish adult cognitive function. With recent advent of dissection techniques, is now feasible examine circuit-specific in connectivity, activity, function animal models. Here, we propose that balance local long-range inputs onto frontal an understudied metric maturation. This review highlights research on a frontal-sensory attention undergoes refinement local/long-range regulated by activity neuromodulatory signaling, evaluates how this process may occur generally cortex support behavior. Notably, can be bidirectionally disrupted through various mechanisms relevant psychiatric disorders. Pharmacological or environmental interventions normalize reset could hold great therapeutic promise prevent rescue deficits.
Язык: Английский
Процитировано
1
NeuroImage Clinical, Год журнала: 2024, Номер 43, С. 103630 - 103630
Опубликована: Янв. 1, 2024
Past work has shown that people with schizophrenia exhibit more cross-subject heterogeneity in their functional connectivity patterns. However, it remains unclear whether specific brain networks are implicated, common confounds could explain the results, or task activations might also be heterogeneous. Unambiguously establishing existence and extent of constitutes a first step toward understanding why emerges what means clinically. Methods. We leveraged data from HCP Early Psychosis project. Functional (FC) was extracted 718 parcels via principal components regression. Networks were defined network partition (Ji et al., 2019). examined an independent set controls, later-stage patients, ADHD patients during rest working memory task. quantified by averaging Pearson correlation distance each subject's FC activity pattern to every other subject same cohort. Results. Affective non-affective early psychosis exhibited whole-brain than healthy controls (ps < 0.001, Hedges' g > 0.74). Increased found up seven networks. In-scanner motion, medication, nicotine, comorbidities not results. Later-stage heterogeneous patterns compared control subjects. Interestingly, individual connection weights, parcel-wise activations, averages thereof variable suggesting becomes most obvious over large-scale Conclusion. Whole-brain characterizes Developmental pathophysiological consequences discussed.
Язык: Английский
Процитировано
0
Current topics in behavioral neurosciences, Год журнала: 2022, Номер unknown, С. 315 - 362
Опубликована: Янв. 1, 2022
Язык: Английский
Процитировано
0