Frontostriatal salience network expansion in individuals in depression

Nature, Год журнала: 2024, Номер 633(8030), С. 624 - 633

Опубликована: Сен. 4, 2024

Язык: Английский

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EEG microstate as a biomarker of personalized transcranial magnetic stimulation treatment on anhedonia in depression

Behavioural Brain Research, Год журнала: 2025, Номер 483, С. 115463 - 115463

Опубликована: Фев. 5, 2025

Язык: Английский

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Accelerated intermittent theta burst transcranial magnetic stimulation of the dorsolateral prefrontal cortex for chronic knee osteoarthritis pain

Clinical Neurophysiology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

This study assessed feasibility, safety, and tolerability of accelerated intermittent theta burst stimulation (aiTBS) with effective connectivity-guidance targeting the left dorsolateral prefrontal cortex (lDLPFC) from right anterior insular (rAI) in chronic knee osteoarthritis pain. The BoostCPM clinical trial (ISRCTN15404076) was a randomized, sham-controlled, single-blind, parallel-group pilot patients mild-moderate Participants were assigned 2:1 (active: sham) aiTBS for 4 consecutive days (totaling 36,000 pulses) at daily dose 9000 pulses (5 sessions 1800 pulses). Primary outcomes included tolerability, pain-related affective outcomes, quantitative sensory testing. 45 participants received active (n = 33) or sham 12) aiTBS. No serious adverse events recorded, protocol adherence (tolerability) 80.6 % 100 sham. Follow-up response rate 78.1 overall acceptance/satisfaction 89 %. Pain relief observed immediately after treatment lasted 16 weeks clinically meaningful reduction pain burden, but no differences between groups. rAI-connected lDLPFC is safe, well tolerated, feasible, acceptable intervention patients. However, we found additional improvements compared to Further studies are warranted.

Язык: Английский

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Neural correlates of insomnia with depression and anxiety from a neuroimaging perspective: A systematic review

Sleep Medicine Reviews, Год журнала: 2025, Номер 81, С. 102093 - 102093

Опубликована: Май 2, 2025

Язык: Английский

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Dose-dependent target engagement of a clinical iTBS protocol: An interleaved TMS-fMRI study in healthy subjects

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Год журнала: 2024, Номер unknown

Опубликована: Авг. 1, 2024

Intermittent theta burst stimulation (iTBS) of the dorsolateral prefrontal cortex (DLPFC) is widely applied as a therapeutic intervention in mental health; however, understanding its mechanisms still incomplete. Prior magnetic resonance imaging (MRI) studies have mainly used offline iTBS or short sequences concurrent transcranial (TMS)-functional MRI (fMRI). This study investigated full 600-stimuli protocol using interleaved TMS-fMRI comparison with 2 control conditions healthy subjects. In crossover design, 18 participants underwent 3 sessions iTBS-fMRI: 1) left DLPFC at 40% resting motor threshold (rMT) intensity, 2) 80% rMT and 3) primary (M1) intensity. We compared immediate blood oxygen level-dependent (BOLD) responses during iTBS-fMRI across these including correlations between individual fMRI BOLD activation iTBS-induced electric field strength target sites. Whole-brain analysis showed increased several regions following iTBS. Specifically, DLPFC, well bilateral M1, anterior cingulate cortex, insula, stimulation. Increased activity was observed neither nor M1 iTBS, whereas other found to overlap conditions. Of note, intensities were only correlated for not dosage- target-specific individuals. Future may use our approach investigating engagement clinical samples.

Язык: Английский

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Engineering and Technological Advancements in Repetitive Transcranial Magnetic Stimulation (rTMS): A Five-Year Review

Brain Sciences, Год журнала: 2024, Номер 14(11), С. 1092 - 1092

Опубликована: Окт. 30, 2024

In the past five years, repetitive transcranial magnetic stimulation (rTMS) has evolved significantly, driven by advancements in device design, treatment protocols, software integration, and brain-computer interfaces (BCIs). This review evaluates how these innovations enhance safety, efficacy, accessibility of rTMS while identifying key challenges such as protocol standardization ethical considerations. A structured peer-reviewed studies from 2019 to 2024 focused on technological clinical rTMS, including AI-driven personalized treatments, portable devices, integrated BCIs. AI algorithms have optimized patient-specific devices expanded access. Enhanced coil designs BCI integration offer more precise adaptive neuromodulation. However, remain standardizing addressing complexity, ensuring equitable While recent improve rTMS's utility, gaps long-term efficacy concerns persist. Future research must prioritize standardization, accessibility, robust frameworks ensure sustainable impact.

Язык: Английский

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Non-invasive brain stimulation in research and therapy

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 26, 2024

Since the introduction of transcranial magnetic stimulation (TMS) almost four decades ago, non-invasive brain (NIBS) techniques have emerged as promising tools to study brain-behaviour relationships in healthy and impaired states with unprecedented precision. Various NIBS techniques, including TMS, direct current (tDCS), emerging methods such alternating (tACS) random noise (tRNS) are employed both research clinical settings. TMS has gained regulatory approval for treating conditions like major depressive disorder migraine, while tDCS is showing efficacy enhancing cognitive functions various populations. This collection articles examines key studies, modulation cognitive-motor functions, optimization light Alzheimer's therapy, effects on risk-taking behaviour violent offenders. Notably, findings suggest that can effectively influence executive decision-making processes. They highlight integration neuroimaging importance personalized targeting, potential combined therapeutic approaches. Future directions include addressing methodological challenges leveraging artificial intelligence refine treatment protocols. Collectively, these advancements position a transformative tool neuroscience practice, offering new avenues understanding complex neuropsychiatric conditions.

Язык: Английский

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Embracing variability in the search for biological mechanisms of psychiatric illness

Trends in Cognitive Sciences, Год журнала: 2024, Номер 29(1), С. 85 - 99

Опубликована: Ноя. 6, 2024

Язык: Английский

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Mapping Symptom-General and Symptom-Specific Targets for Transcranial Magnetic Stimulation in Schizophrenia: An Electrical Modeling Meta-Analysis

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

Negative, positive, and cognitive symptoms of schizophrenia relate to disruptions in partially distinct brain circuits. Although promising, transcranial magnetic stimulation (TMS) strategies across within symptom domains remain be established due TMS protocol heterogeneity. For this, we combined standard meta-analysis with electric field (E-field) modeling identify sites where E-field strength associated most significantly clinical improvement. Standard randomized, sham-controlled studies 3,806 patients demonstrated benefit domains, regardless target or protocol. Particularly, improved negative high-frequency applied left prefrontal cortex, whereas positive low-frequency temporoparietal cortex. In-depth examination these results identified dorsomedial cortex (L-DMPFC), orbitofrontal (L-OFC), cerebellar crus II right lobule IX improvement all domains. Especially, greater overlap studies’ L-DMPFC L-OFC related outcomes. symptoms, distribution Specifically, proximity site indicated better outcomes, at trend significance for L-OFC. In the domain, frontopolar cortices dorsolateral Finally, strongest association was found lobules VIIIA, VIIIB, symptoms. These support symptom-general symptom-specific approaches therapeutic goals towards personalized neuromodulation schizophrenia.

Язык: Английский

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Deep Brain Stimulation (DBS) and Motor Cortex Stimulation (MCS) for Central Post-Stroke Pain: A Systematic Review And Meta-Analysis

Pain Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract Introduction Deep Brain Stimulation (DBS) and Motor Cortex stimulation (MCS) are invasive interventions in order to treat various neuropathic pain syndromes such as Central Post-Stroke Pain. While each treatment has varying degree of success, comparative analysis not yet been performed, the success rates these techniques using validated, objective scores have synthesised. Methods A systematic review meta-analysis was conducted accordance with PRISMA guidelines. Three databases were searched, articles published from January 2000 October 2024 included (last search date 25 2024). Meta-Analysis performed random effects models. We evaluated performance DBS or MCS by assessing studies that reported relief Visual Analogue Scale (VAS) Numerical Rating (NRS) scores. Results Of 478 identified, 32 (330 patients- 139 DBS, & 191 MCS). The improvement mean VAS score for patients underwent post-surgery 48.6% compared a 53.1% had MCS. pooled number who improved after 0.62 (95% CI, 0.51-0.71, I2=16%). 0.64 0.53-0.74, I2=40%). Conclusion use neurosurgical last-resort treatments Pain, limited exploring comparing two techniques. our study shows might be slightly better option, further research would need done determine appropriate surgical intervention

Язык: Английский

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