Curcumin reverses cognitive deficits through promoting neurogenesis and synapse plasticity via the upregulation of PSD95 and BDNF in mice

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 7, 2025

Following prolonged exposure to hypoxic conditions, for example, due ascent high altitude, aging or stroke, cognitive deficits can develop. The exact nature and genesis of hypoxia-induced remain unresolved. Curcumin has been reported stimulate neurogenesis reduce neuronal degeneration. This study aimed investigate the effect curcumin on in hypoxic-brain injury mice its potential mechanism. Eight-week-old male C57BL/6J were normobaric-hypoxia (13%O2) 14 days establish models. Morris water maze novel object recognition used detect function each mouse. Immunofluorescence assays, including Fluoro-Jade C (FJC) bromodeoxyuridine (BrdU), degeneration neurogenesis. Thy1-YFP transgenic synapse plasticity. Our results showed that administration rescued impaired cognition mice, shown as enhanced BrdU+ dendritic spine hippocampus. At molecular level, was found promote expression brain-derived neurotrophic factor (BDNF) postsynaptic density protein 95 (PSD95). primary hippocampal neuron detection could growth. In conclusion, our indicates curcumin, increased BDNF PSD95 contacted with interneurons, salvaged interneurons may normalize ambient neuroplasticity, resulting preservation processes well contributing improve performance.

Язык: Английский

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Neuromodulation of Fear and Anxiety Circuits

Current topics in behavioral neurosciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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The Role of Brain Derived Neurotrophic Factor Polymorphism in Transcranial Magnetic Stimulation Response for Major Depressive Disorder

Journal of Ect, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Repetitive transcranial magnetic stimulation (rTMS) is a safe and effective therapy for treatment-resistant depression (TRD). A crucial next step in improving rTMS to identify response predictors inform patient selection criteria. Brain-derived neurotrophic factor (BDNF) exerts influence over TRD treatment modalities. BDNF polymorphism, Val66Met, has shown altered cortical plasticity after single-session healthy subjects clinical noninvasive brain methods major depressive disorder, stroke, Alzheimer's, cerebral palsy. We sought evaluate the effect of this polymorphism on standard course TRD. In naturalistic study, 75 patients with completed weekly assessments via Inventory Depressive Symptomatology Self-Report (IDS-SR). polymorphisms were retrospectively compared respect remission, baseline final scores, percent change scores across 6-week course. As expected, significantly decreased symptoms as measured by IDS-SR scores. No difference was found baseline, final, or between types. There no Response remission rates did not differ genotypes. contrast previous research highlighting differential motor outcomes, our data suggest that status may 10-Hz disorder. Differences TMS protocol, target, serum levels underlie results.

Язык: Английский

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Neuromodulation as a therapeutic approach for post-traumatic stress disorder: the evidence to date

Expert Review of Neurotherapeutics, Год журнала: 2024, Номер unknown, С. 1 - 20

Опубликована: Дек. 20, 2024

Post-traumatic stress disorder (PTSD) can have debilitating effects on quality of life, and conventional treatments show mixed results. Neuromodulation is emerging as a promising approach for treating PTSD. This review examines current neuromodulatory PTSD, highlights methodologies, clinical outcomes, gaps in the literature to help guide future research.

Язык: Английский

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