Foods,
Год журнала:
2024,
Номер
13(6), С. 950 - 950
Опубликована: Март 20, 2024
Polyhydroxyalkanoates
(PHAs)
are
high-value
biodegradable
polyesters
with
thermoplastic
properties
used
in
the
manufacturing
of
different
products
such
as
packaging
films.
PHAs
have
gained
much
attention
from
researchers
and
industry
because
their
biobased
nature
appropriate
features,
similar
to
conventional
synthetic
plastics.
This
review
aims
discuss
some
recent
solutions
challenges
associated
PHA
production.
The
implementation
a
cost-effective
process
is
presented
by
following
strategies,
use
inexpensive
carbon
sources,
selection
high-producing
microorganisms,
functionalization
final
materials
make
them
suitable
for
food
applications,
among
others.
Research
efforts
needed
improve
economic
viability
production
at
large
scale.
Haloferax
mediterranei
promising
producer
due
its
ability
grow
non-sterile
conditions
possibility
using
seawater
prepare
growth
medium.
Additionally,
downstream
processing
extraction
can
be
simplified
treating
H.
cells
pure
water.
Further
research
should
focus
on
optimization
recycling
effluents
side
streams
reutilization
desalinization
an
integrated
part
biotechnological
Biotechnology and Bioengineering,
Год журнала:
2024,
Номер
121(7), С. 2106 - 2120
Опубликована: Апрель 8, 2024
Abstract
Microbial
production
of
polyhydroxyalkanoate
(PHA)
is
greatly
restricted
by
high
cost
arising
from
high‐temperature
sterilization
and
expensive
carbon
sources.
In
this
study,
a
low‐cost
PHA
platform
was
established
Halomonas
cupida
J9.
First,
marker‐less
genome‐editing
system
developed
in
H.
Subsequently,
J9
engineered
to
efficiently
utilize
xylose
for
biosynthesis
introducing
new
metabolism
module
blocking
xylonate
production.
The
strain
J9UΔ
xylD
‐P8
xylA
has
the
highest
yield
(2.81
g/L)
obtained
with
as
sole
source
so
far.
This
first
report
on
short‐
medium‐chain‐length
(SCL‐
co
‐MCL)
.
Interestingly,
capable
utilizing
glucose
co‐carbon
sources
Furthermore,
fed‐batch
fermentation
coupled
glucose/xylose
co‐feeding
strategy
reached
up
12.57
g/L
5‐L
bioreactor
under
open
unsterile
condition.
Utilization
corn
straw
hydrolysate
7.0
cell
dry
weight
(CDW)
2.45
an
fermentation.
summary,
combination
inexpensive
feedstock
highlights
potential
lignocellulose‐rich
agriculture
waste.
ACS Sustainable Chemistry & Engineering,
Год журнала:
2022,
Номер
10(50), С. 16459 - 16475
Опубликована: Дек. 5, 2022
In
light
of
the
current
concerns
about
environmental
issues
caused
by
excessive
use
fossil
resources,
more
emphasis
has
been
paid
to
transition
a
sustainable
and
circular
economy.
Bioplastics
as
eco-friendly
products
originating
from
biomass
wastes
have
gained
much
attention
solve
problem
plastic
pollution.
Among
them,
polyhydroxyalkanoates
(PHAs)
are
microbial
polyesters
produced
using
various
feedstocks─renewable
or
recycled
waste
materials─contributing
commercial
life
cycle
being
part
bioeconomy.
However,
scale-up
PHA
process
cost
effectively
sustainably
remains
challenging
for
large-scale
industrial
applications.
This
perspective
provides
comprehensive
overview
insights
into
lignocellulosic
biomass's
role
in
achieving
Emerging
greener
conversion
technologies
discussed
characterize
energy
demand,
cost,
sustainability
within
biorefinery
production.
addition,
recent
advances
synthetic
biology
fermentation
processes
production
discussed.
Technological
challenges,
i.e.,
bioreactor
setup,
downstream
operation,
inconsistent
properties
improve
PHAs
help
transfer
this
technology
real-world
applications,
also
addressed.
