Journal of Computational Electronics, Год журнала: 2022, Номер unknown
Опубликована: Ноя. 15, 2022
Язык: Английский
Optics Express, Год журнала: 2022, Номер 30(10), С. 16630 - 16630
Опубликована: Апрель 21, 2022
Terahertz (THz) metamaterials for rapid label-free sensing show application potential the detection of cancer biomarkers. A novel flexible THz metamaterial biosensor based on a low refraction index parylene-C substrate is proposed. The biomarkers are modified non-metal areas by three-step modification method that simplifies steps and improves effectivity. Simulation results illustrate bulk refractive sensitivity 325 GHz/RIU achieved, which larger than obtained traditional metal (147 GHz/RIU). Meanwhile, several fluorescence experiments proved uniform effect selective adsorption capacity method. concentration carcinoembryonic antigen (CEA) breast patients tested using this found to be consistent with from clinical tests. limit reaches 2.97 ng/mL. These findings demonstrate can extensively used in future.
Язык: Английский
Процитировано
34
Materials Today Advances, Год журнала: 2022, Номер 14, С. 100219 - 100219
Опубликована: Фев. 16, 2022
Female breast cancer is the leading cause of global incidence and fifth mortality worldwide in 2020. Breast can be categorized into different subtypes according to expression biomarkers such as estrogen receptors (ER), progesterone (PR) human epidermal growth factor receptor 2 (HER2). The analysis these also indispensable for systemic treatment decisions cancer. In this review, we summarized recent progress detection blood utilizing nanomaterials. attractive physical, chemical, optical electronic properties various nanomaterials facilitated improved performance detection. relatively non-invasive provide useful biological information that complementary imaging examination immunohistochemistry.
Язык: Английский
Процитировано
33
Analytical Chemistry, Год журнала: 2022, Номер 94(28), С. 10206 - 10212
Опубликована: Июль 1, 2022
As a class of oligosaccharide chain-containing proteins, glycoproteins are great value in screening and early diagnosis malignant tumors other major diseases. Herein, we report universal boronate affinity-based electrochemical aptasensor for point-of-care glycoprotein detection. Aptasensing involves the specific recognition capture target by end-tethered nucleic acid aptamers site-specific labeling ferrocene tags via phenylboronic (PBA)-based affinity interactions because cis-diol sites chains on can selectively react with PBA receptor groups to form cyclic phenylborates aqueous basic media. Due presence hundreds thousands glycoprotein, large number be recruited signal-on aptasensing at low-abundance level, eliminating need extra amplification strategies. result, is highly sensitive selective detection tolerant false-positive results. The limit α-fetoprotein (AFP) 0.037 ng/mL, linear response ranging from 0.1 100 ng/mL. In addition merits simple operation, short assay time, low cost, applicable serum samples using disposable flexible electrodes. Overall, this work provides promising platform glycoproteins, holding potential glycoprotein-related
Язык: Английский
Процитировано
33
Heliyon, Год журнала: 2022, Номер 8(12), С. e12207 - e12207
Опубликована: Дек. 1, 2022
A rapid surge in world population leads to an increase worldwide demand for agricultural products. Nanotechnology and its applications agriculture have appeared as a boon civilization with enormous potential transforming conventional farming practices into redefined activities. Low-cost portable nanobiosensors are the most effective diagnostic tool on-site assessment of plant soil health including biotic abiotic stress level, nutritional status, presence hazardous chemicals soil, etc. maintain proper crop productivity. Nanobiosensors detect physiological signals convert them standardized detectable signals. In order achieve reliable sensing analysis, nanoparticles can aid signal amplification sensor sensitivity by lowering detection limit. The high selectivity enable early management targeted abnormalities. This study identifies types according target application sector.
Язык: Английский
Процитировано
31
Journal of Computational Electronics, Год журнала: 2022, Номер unknown
Опубликована: Ноя. 15, 2022
Язык: Английский
Процитировано
30