Biomarkers
contained
in
human
exhaled
breath
are
closely
related
to
certain
diseases.
As
a
noninvasive,
portable,
and
efficient
health
diagnosis
method,
the
sensor
has
received
considerable
attention
recent
years
for
early
disease
screening
prevention
due
its
user-friendly
easy-accessible
features.
Although
some
key
challenges
have
been
addressed,
capability
precisely
monitor
specific
biomarkers
of
interest
physiological
relevance
metrics
is
still
be
ascertained.
In
this
context,
we
analyzed
rational
design
advance
sensors
healthcare
monitoring.
This
review
begins
with
an
introduction
their
sensing
technologies,
such
as
chemoresistive,
humidity-sensitive,
electrochemical,
colorimetric
principles.
Then,
systematic
overview
emerging
applications
screening,
drunk
driving
inspection,
apnea
monitoring,
condensate
analysis
demonstrated.
Finally,
discuss
opportunities
noninvasive
With
ongoing
research
efforts,
continuous
breakthrough
attractive
foreseeable
future.
Abstract
Printed
flexible
electronics
have
emerged
as
versatile
functional
components
of
wearable
intelligent
devices
that
bridge
the
digital
information
networks
with
biointerfaces.
Recent
endeavors
in
plant
sensors
provide
real‐time
and
situ
insights
to
study
phenotyping
traits
crops,
whereas
monitoring
ethylene,
fundamental
phytohormone,
remains
challenging
due
lack
scalable
manufacturing
ethylene
sensors.
Here
all‐MXene‐printed
radio
frequency
(RF)
resonators
are
presented
for
wireless
detection.
The
facile
formation
additive‐free
MXene
ink
enables
rapid,
printed
electronics,
demonstrating
decent
printing
resolution
(2.5%
variation),
≈30000
S
m
−1
conductivity
mechanical
robustness.
Incorporation
MXene‐reduced
palladium
nanoparticles
(MXene@PdNPs)
facilitates
1.16%
response
at
1
ppm
0.084
limit
sensor
tags
attached
on
organ
surfaces
continuously
profiling
emission
inform
key
transition
biochemistry,
potentially
extending
application
enable
hormone
precision
agriculture
food
industrial
management.
ACS Sensors,
Год журнала:
2024,
Номер
9(9), С. 4469 - 4494
Опубликована: Сен. 9, 2024
Lung
cancer
remains
a
global
health
concern,
demanding
the
development
of
noninvasive,
prompt,
selective,
and
point-of-care
diagnostic
tools.
Correspondingly,
breath
analysis
using
nanobiosensors
has
emerged
as
promising
noninvasive
nose-on-chip
technique
for
early
detection
lung
through
monitoring
diversified
biomarkers
such
volatile
organic
compounds/gases
in
exhaled
breath.
This
comprehensive
review
summarizes
state-of-the-art
breath-based
diagnosis
employing
chemiresistive-module
supported
by
theoretical
findings.
It
unveils
fundamental
mechanisms
biological
basis
biomarker
generation
associated
with
cancer,
technological
advancements,
clinical
implementation
nanobiosensor-based
analysis.
explores
merits,
challenges,
potential
alternate
solutions
implementing
these
settings,
including
standardization,
biocompatibility/toxicity
analysis,
green
sustainable
technologies,
life-cycle
assessment,
scheming
regulatory
modalities.
highlights
nanobiosensors'
role
facilitating
precise,
real-time,
on-site
leading
to
improved
patient
outcomes,
enhanced
management,
remote
personalized
monitoring.
Additionally,
integrating
biosensors
artificial
intelligence,
machine
learning,
Internet-of-things,
bioinformatics,
omics
technologies
is
discussed,
providing
insights
into
prospects
intelligent
sniffing
nanobiosensors.
Overall,
this
consolidates
knowledge
on
breathomic
biosensor-based
screening,
shedding
light
its
significance
applications
advancing
medical
diagnostics
reduce
burden
hospitals
save
human
lives.
MXene-based
materials
have
attracted
significant
interest
due
to
their
distinct
physical
and
chemical
properties,
which
are
relevant
fields
such
as
energy
storage,
environmental
science,
biomedicine.
MXene
has
shown
potential
in
the
area
of
tissue
regenerative
medicine.
However,
research
on
its
applications
regeneration
is
still
early
stages,
with
a
notable
absence
comprehensive
reviews.
This
review
begins
detailed
description
intrinsic
properties
MXene,
followed
by
discussion
various
nanostructures
that
can
form,
spanning
from
0
3
dimensions.
The
focus
then
shifts
biomaterials
engineering,
particularly
immunomodulation,
wound
healing,
bone
regeneration,
nerve
regeneration.
MXene's
physicochemical
including
conductivity,
photothermal
characteristics,
antibacterial
facilitate
interactions
different
cell
types,
influencing
biological
processes.
These
highlight
modulating
cellular
functions
essential
for
Although
developing,
versatile
structural
attributes
suggest
role
advancing
ECS Journal of Solid State Science and Technology,
Год журнала:
2023,
Номер
12(3), С. 037003 - 037003
Опубликована: Март 1, 2023
The
state-of-the-art
diabetes
diagnosis
is
concerned
with
developing
non-invasive
nano-enabled
exhaled
breath-acetone
detection
strategies.
This
communication
details
the
potential
of
polypyrrole(PPy)–
Silver/silver
chloride
(Ag/AgCl)
ternary
nanocomposites
(NCs)
for
monitoring
low-trace
acetone
in
human
breath
diagnosis.
PPy–Ag/AgCl
NCs
were
synthesized
through
situ
chemical
oxidative
polymerization
aniline
by
silver
nitrate
presence
hydrochloric
acid.
morphological
analysis
revealed
existence
spherical
Ag/AgCl
nanoparticles
(diameter
∼50
nm)
embedded
PPy
matrix
nano
fibrillar
morphology
∼20
nm).
structural
investigations
confirm
co-existence
PPy,
Ag
and
AgCl
nanocomposite.
NC
exhibited
manifold
superior
sensing
performance
towards
low
trace
(as
as
∼1
ppm)
excellent
sensitivity
(∼20%),
prompt
response
(∼20
s),
fast
recovery
(∼100s),
linear
detecting
range,
high
repeatability
at
room
temperature
compared
to
pristine
PPy.
It
attributed
synergistic
effects
due
physicochemical
merits
all
precursors.
Moreover,
it
showed
stability
selectivity
prominent
interfering
VOCs
varying
humidity.
opens
a
new
window
non-invasive,
economic,
energy-efficient
point-of-care
sensors
diagnosing
humans
and,
revolutionizing
clinical
diagnostics
personal
healthcare.
