Biosensors,
Год журнала:
2024,
Номер
14(12), С. 592 - 592
Опубликована: Дек. 3, 2024
The
COVID-19
pandemic
has
prompted
the
need
for
development
of
new
biosensors
SARS-CoV-2
detection.
Particularly,
systems
with
qualities
such
as
sensitivity,
fast
detection,
appropriate
to
large-scale
analysis,
and
applicable
in
situ,
avoiding
using
specific
materials
or
personnel
undergo
test,
are
highly
desirable.
In
this
regard,
developing
an
electrochemical
biosensor
based
on
peptides
derived
from
angiotensin-converting
enzyme
receptor
2
(ACE2)
is
a
possible
answer.
To
end,
impedimetric
detector
was
developed
graphite
electrode
surface
modified
ACE2
peptide-mimic.
This
sensor
enables
accurate
quantification
recombinant
2019-nCoV
spike
RBD
protein
(used
model
analyte)
within
linear
detection
range
0.167–0.994
ng
mL−1,
providing
reliable
method
detecting
SARS-CoV-2.
observed
sensitivity
further
demonstrated
by
molecular
dynamics
that
established
high
affinity
specificity
peptide
protein.
Unlike
other
sensors,
herein
presented
system
can
detect
impedance
single
frequency,
allowing
measure
3
min
complete
analysis
achieving
limit
45.08
pg
mL−1.
Thus,
proposed
peptide-based
offers
results
adequate
opening
path
developments
concerning
viruses
interest.
Advances in Natural Sciences Nanoscience and Nanotechnology,
Год журнала:
2023,
Номер
14(3), С. 033001 - 033001
Опубликована: Авг. 17, 2023
Abstract
A
critical
step
in
the
process
for
preventing
and
identifying
emergencies
relating
to
health,
safety,
welfare
is
testing
quick
diagnosis
of
microbial
pathogens.
Due
fast
spread
waterborne
food
borne
infections
society
high
costs
associated
with
them,
pathogen
identification
has
emerged
as
one
most
difficult
parts
water
sectors.
Since
turn
century,
pathogens
have
demonstrated
enormous
epidemiological
pandemic
potential.
The
emergence
dissemination
a
novel
virus
potential
endanger
livelihoods
well-being
individuals
worldwide.
severe
acute
respiratory
syndrome-coronavirus-2
(SARS-COV-2)
coronavirus
propagated
almost
every
country
on
Earth
had
considerable
negative
influence
economies
communities.
Despite
improvements
techniques
viral
diseases,
all
nations
must
now
execute
biosensing
speedy,
sensitive,
focused,
consistent
manner
order
address
pressing
global
issues.
Hence,
this
review,
we
critically
summarised
recent
advancement
electrochemical
well
optical
biosensors
monitoring
SARS-COV-2
various
Then,
began
by
providing
technical
overview
cutting-edge
strategies
utilised
combat
diseases
it,
including
utilisation
point-of-care
technology
(POCT),
artificial
intelligence
(AI),
internet
medical
things
(IoMT).
This
review
article
explores
integration
POC,
IoMT,
AI
technologies
context
personal
healthcare,
focusing
their
expedite
treatment
conditions,
ultimately
leading
improved
patient
outcomes.
Subsequently,
notion
execution
multiplex
are
presented
enhance
comprehension
detecting
multiple
analytes.
Finally,
conclusions
future
directions
been
presented.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(29)
Опубликована: Март 18, 2024
Abstract
Biologically
inspired
peptide‐based
materials,
as
novel
charge
transport
have
gained
increasing
interest
in
bioelectronics
due
to
their
remarkable
electrical
properties
and
inherent
biocompatibility.
Extensive
studies
shown
that
peptides
can
self‐assemble
into
a
variety
of
hierarchical
nanostructures
with
unique
physical
through
supramolecular
interactions.
Therefore,
materials
hold
great
promise
for
applications
emerging
electronic
fields
such
sensing,
energy
harvesting,
storage,
transmission.
Herein,
this
work
proposes
review
article
summarize
the
rational
design
research
progress
devices
bioelectronics.
This
first
introduces
strategies
assembly
mechanism
constructing
high‐performance
devices.
In
following
part,
are
systematically
classified
discussed,
including
sensors,
piezoelectric
nanogenerators,
electrodes,
semiconductors.
Finally,
remaining
challenges
future
perspectives
bioelectronic
presented.
believes
will
provide
inspiration
guidance
development
innovative
smart
field
Advanced Sensor Research,
Год журнала:
2024,
Номер
3(5)
Опубликована: Фев. 5, 2024
Abstract
Electrochemical
biosensing
represents
a
highly
effective
technology
for
detecting
disease
biomarkers
given
its
high
sensitivity,
low
and
clinically
relevant
limit
of
detection,
cost
effectiveness.
However,
in
complex
media
such
as
urine,
blood,
sweat
or
saliva,
performance
can
be
significantly
impacted
by
electrode
biofouling
proteins,
cells,
lipids,
other
matrix
components.
Such
leads
to
reduced
signal
from
the
target
analyte
coupled
with
an
elevated
background
signal,
resulting
poor
signal‐to‐noise
ratios
(SNRs),
lower
specificity.
This
comprehensive
review
describes
design
anti‐fouling
polymers
peptides
potential
solution
prevent
suppress
electrochemical
biosensor
fouling.
Various
developed
improved
are
summarized
context
their
mechanism(s)
anti‐fouling,
methods
deposition,
practical
applications.
Recent
advances
persistent
challenges
field
also
reviewed
provide
perspectives
on
new
directions
toward
enhancing
biosensors.
Alexandria Engineering Journal,
Год журнала:
2023,
Номер
81, С. 1 - 6
Опубликована: Сен. 9, 2023
Alzheimer's
disease
(AD)
is
a
neurodegenerative
disorder
characterized
by
the
accumulation
of
amyloid-beta
(Aβ)
peptides
in
brain.
Among
different
forms
Aβ,
oligomers
(Aβo)
are
considered
most
toxic
and
have
been
implicated
AD
pathology.
However,
accurate
detection
Aβo
remains
challenging
due
to
their
low
abundance
structural
complexity.
In
this
study,
we
propose
an
electrochemical
sensing
platform
based
on
gold
nanostars
(AuS)
for
AD.
The
AuS
were
functionalized
with
peptide
probe
(PrPc)
that
specifically
interacts
Aβo.
PrPc-AuS
exhibited
high
sensitivity
selectivity
detection.
impedance
spectroscopy
(EIS)
analysis
showed
significant
changes
upon
binding
surface,
providing
quantitative
information
about
concentration.
demonstrated
linear
range
5–200
pM
limit
2
pM,
meeting
requirements
clinical
This
offers
promising
approach
early
diagnosis
monitoring
AD,
contributing
development
point-of-care
diagnostics
diseases.
ACS Omega,
Год журнала:
2024,
Номер
9(28), С. 30737 - 30750
Опубликована: Июль 6, 2024
Acute
myocardial
infarction
(AMI)
is
a
severe
cardiovascular
disease
characterized
by
heart
muscle
damage
due
to
inadequate
blood
supply,
leading
life-threatening
risk
of
attack.
Herein,
we
report
on
the
design
polyaminophenol-based
thin
film
functional
polymers
and
their
thorough
optimization
electrochemical,
spectroscopic,
microscopic
techniques
develop
high-performance
point-of-care
voltammetric
monitoring
system.
Molecularly
imprinted
polymer-based
cTnI-responsive
nanocomposite
materials
were
prepared
an
electrode
surface
imprinting
specific
cTnI
epitope,
integrating
polyaminophenol
electrodeposition,
along
with
gold
nanoparticles
(AuNPs)
graphene
quantum
dots
(GQDs).
The
characterization
techniques,
including
cyclic
square
wave
voltammetries,
electrochemical
impedance
spectroscopy,
atomic
force
microscopy,
fluorescence
attenuated
total
reflection-Fourier
transform
infrared
spectroscopy
(ATR-FTIR),
contact
angle
measurements
proved
efficient
fabrication
system
relying
films.
sensing
platform
optimized
composition
AuNPs,
GQDs,
molecularly
exhibited
very
high
sensitivity,
reproducibility,
specificity,
affinity
toward
cTnI.
sensor
showed
storage
stability
30
days,
demonstrating
great
potential
for
use
in
early
diagnosis
AMI
its
18
min
detection
time.
