Microsystems & Nanoengineering,
Год журнала:
2025,
Номер
11(1)
Опубликована: Май 22, 2025
Blood
vessels
are
hierarchical
microchannels
that
transport
nutrients
and
oxygen
to
different
tissues
organs,
while
also
eliminating
metabolic
waste
from
the
body.
Disorders
of
vascular
system
impact
both
physiological
pathological
processes.
Conventional
animal
models
complex,
high-cost,
time-consuming,
low-validity,
which
have
limited
exploration
effective
in
vitro
microsystems.
The
morphologies
micro-scaled
tubular
structures
properties
tissues,
including
mechanical
strength,
thrombogenicity,
immunogenicity,
can
be
mimicked
by
engineering
strategies.
This
review
highlights
state-of-the-art
advanced
strategies
for
microsystems,
covering
domains
related
rational
designs,
manufacturing
approaches,
supporting
materials,
organ-specific
cell
types.
A
broad
range
biomedical
applications
microsystems
summarized,
recent
advances
engineered
vascularized
organs
study,
drug
screening,
personalized
medicine.
Moreover,
commercialization
feasibility
limitations
current
commercially
available
products,
as
well
perspectives
on
future
directions
exploration,
elaborated.
modeling
will
facilitate
rapid,
robust,
efficient
analysis
tissue
broader
regenerative
medicine
towards
development
treatment
approaches.
ACS Omega,
Год журнала:
2024,
Номер
9(12), С. 13534 - 13555
Опубликована: Март 7, 2024
Pulmonary
diseases
like
asthma,
chronic
obstructive
pulmonary
disorder,
lung
fibrosis,
and
cancer
pose
a
significant
burden
to
global
human
health.
Many
of
these
complications
arise
as
result
exposure
particulate
matter
(PM),
which
has
been
examined
in
several
preclinical
clinical
trials
for
its
effect
on
respiratory
diseases.
Particulate
size
less
than
2.5
μm
(PM2.5)
known
inflict
unforeseen
repercussions,
although
data
from
epidemiological
studies
back
this
are
pending.
Conventionally
utilized
two-dimensional
(2D)
cell
culture
animal
models
have
provided
insufficient
benefits
emulating
the
vivo
physiological
pathological
conditions.
Three-dimensional
(3D)
structural
models,
including
organ-on-a-chip
experienced
developmental
upsurge
recent
times.
Lung-on-a-chip
potential
simulate
specific
features
lungs.
With
advancement
technology,
an
emerging
advanced
technique
termed
microfluidic
developed
with
aim
identifying
complexity
cellular
microenvironment
body.
In
present
Review,
role
lung-on-a-chip
modeling
reproducing
explored,
emphasis
PM2.5-induced
complications.
Biosensors,
Год журнала:
2024,
Номер
14(9), С. 425 - 425
Опубликована: Сен. 3, 2024
Traditional
drug
development
is
a
long
and
expensive
process
with
high
rates
of
failure.
This
has
prompted
the
pharmaceutical
industry
to
seek
more
efficient
frameworks,
driving
emergence
organ-on-a-chip
(OOC)
based
on
microfluidic
technologies.
Unlike
traditional
animal
experiments,
OOC
systems
provide
accurate
simulation
human
organ
microenvironments
physiological
responses,
therefore
offering
cost-effective
platform
for
biomedical
research,
particularly
in
new
medicines.
Additionally,
enable
quick
real-time
analysis,
high-throughput
experimentation,
automation.
These
advantages
have
shown
significant
promise
enhancing
process.
The
success
an
system
hinges
integration
specific
designs,
manufacturing
techniques,
biosensors
meet
need
integrated
multiparameter
datasets.
review
focuses
manufacturing,
design,
sensing
systems,
applications
highlighting
their
design
capabilities,
as
well
technical
challenges
they
currently
face.
Abstract
The
burgeoning
demand
for
healthcare
monitoring
has
brought
field
effect
transistor
(FET)
biosensors
into
the
spotlight
as
a
highly
efficient
detection
technology.
FET
offer
inherent
advantages
including
high
sensitivity,
rapid
response
times,
operational
simplicity,
integrability,
and
label‐free
detection.
These
characteristics
render
them
particularly
well‐suited
detecting
diverse
array
of
physiological
parameters
biomarkers,
thereby
furnishing
real‐time
data
crucial
personalized
medicine
disease
prevention.
This
review
aims
to
elucidate
recent
advancements
in
within
realm
management
encompassing
several
facets.
Initially,
this
systematically
analyzes
device
architecture,
sensing
mechanisms,
performance
evaluation
methods
gain
an
in‐depth
understanding
their
principles
features.
Subsequently,
it
focuses
on
application
health‐related
biomarkers
nucleic
acids,
proteins,
exosomes,
viruses,
etc.
Lastly,
presents
engineered
medical
sensor
prototypes
predicated
biosensors,
such
point‐of‐care
testing
devices,
wearable
sensors,
implantable
underscoring
practical
utility
potential
health
management.
In
addition,
addresses
critical
issues
prospects
using
monitoring,
aiming
provide
some
references
insights
research
innovation
field.
Advanced Intelligent Systems,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 24, 2024
Biohybrid
robots
are
soft
that
exploit
unique
characteristics
of
biological
cells
and
tissues
for
motion
generation.
Skeletal
muscle
tissue‐based
bioactuators
respond
to
externally
applied
stimuli,
such
as
electrical
fields.
However,
current
bioactuation
systems
rely
on
open‐loop
control
strategies
lack
knowledge
the
actuator's
state.
The
regulation
output
force
position
biohybrid
requires
self‐sensing
combine
with
sensors
paradigms.
Herein,
a
soft,
fiber‐shaped
mechanical
sensor
based
piezoresistive
composite
is
proposed
efficiently
integrates
engineered
skeletal
tissue
senses
its
contracting
states
in
cell
culture
environment
presence
After
testing
sensor's
insulation
biocompatibility,
sensitivity
typical
strains
(<1%)
characterized,
ability
proven
detect
motions
from
contractile
constructs.
Finally,
it
shown
response
can
feed
an
autonomous
system,
thus
demonstrating
first
proprioceptive
robot
responds
contraction
In
addition
inspiring
implantable
systems,
biomedical
models,
other
bioelectronic
devices,
technology
will
confer
biohybrids
decisional
autonomy,
driving
paradigm
shift
between
intelligent
robots.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 1, 2024
ABSTRACT
Functional
assays
on
intact
tumor
biopsies
can
potentially
complement
and
extend
genomics-based
approaches
for
precision
oncology,
drug
testing,
organs-on-chips
cancer
disease
models
by
capturing
key
determinants
of
therapeutic
response,
such
as
tissue
architecture,
heterogeneity,
the
microenvironment.
Currently,
most
these
rely
fluorescent
labeling,
a
semi-quantitative
method
best
suited
to
be
single-time-point
terminal
assay
or
labor-intensive
immunostaining
analysis.
Here,
we
report
integrated
aptamer
electrochemical
sensors
on-chip,
real-time
monitoring
increases
cytochrome
C,
cell
death
indicator,
from
microdissected
tissues
with
high
affinity
specificity.
The
platform
features
multi-well
sensor
layout
multiplexed
electronic
setup.
aptasensors
measure
in
C
supernatant
mouse
human
tumors
after
exposure
various
treatments.
Since
probe
easily
exchanged
recognize
different
targets,
could
adapted
biomarkers,
providing
critical
information
its
This
approach
not
only
help
develop
more
advanced
but
also
apply
other
complex
vitro
models,
organoids.
Functional
assays
on
intact
tumor
biopsies
can
complement
genomics-based
approaches
for
precision
oncology,
drug
testing,
and
organs-on-chips
cancer
disease
models
by
capturing
key
therapeutic
response
determinants,
such
as
tissue
architecture,
heterogeneity,
the
microenvironment.
Most
of
these
rely
fluorescent
labeling,
a
semiquantitative
method
best
suited
single-time-point
or
labor-intensive
immunostaining
analysis.
Here,
we
report
integrated
aptamer
electrochemical
sensors
on-chip,
real-time
monitoring
cytochrome
C,
cell
death
indicator,
from
microdissected
tissues
with
high
affinity
specificity.
The
platform
features
multi-well
sensor
layout
multiplexed
electronic
setup.
aptasensors
measure
increases
in
C
supernatant
mouse
human
tumors
after
exposure
to
various
treatments.
Because
sensor’s
affinity,
it
primarily
tracks
rising
concentrations
dynamic
changes
during
apoptosis.
This
approach
could
help
develop
more
advanced
apply
other
complex
vitro
models,
organoids.
ABSTRACT
Urogenital
system
tumors
include
prostate
cancer,
bladder
ovarian
and
other
very
common
solid
tumor
diseases
with
high
morbidity
mortality.
The
unique
physiological
anatomical
features
of
the
urogenital
render
it
particularly
amenable
to
application
tissue
imaging
techniques
for
diagnostic
purposes.
advancement
aggregation‐induced
emission
(AIE)
materials
has
addressed
limitations
associated
conventional
fluorescent
that
are
prone
aggregation‐caused
quenching.
This
facilitated
development
innovative
AIE
characterized
by
enhanced
photostability,
an
increased
signal‐to‐noise
ratio,
improved
quality.
article
reviews
research
progress
biosensors
in
diagnosis
tumors.
It
mainly
involves
biomarker
vitro
fluorescence
such
as
uterine
which
based
on
biosensors.
In
addition,
a
comprehensive
description
biosensors’
synthesis
strategies
is
provided.
includes
detailed
elucidation
platforms
intracellular
mechanisms
basic
principles
AIE,
accompanied
presentation
quantitative
analysis
cell
results.
limitations,
challenges
suggestions
field
summarized,
prospect
prospected.
tumors,
also
provides
catalyst
exploring
characteristics
its
wide
disease
diagnosis.
