Biosensors,
Год журнала:
2024,
Номер
14(12), С. 564 - 564
Опубликована: Ноя. 21, 2024
This
review
examines
recent
advances
in
surface-enhanced
Raman
spectroscopy
(SERS)
for
urinary
metabolite
analysis,
focusing
on
the
development
and
application
of
noble
metal
nanohybrids.
We
explore
diverse
range
hybrid
materials,
including
carbon-based,
metal–organic-framework
(MOF),
silicon-based,
semiconductor,
polymer-based
systems,
which
have
significantly
improved
SERS
performance
detecting
key
biomarkers.
The
principles
underlying
enhancement
these
nanohybrids
are
discussed,
elucidating
both
electromagnetic
chemical
mechanisms.
analyze
various
fabrication
methods
that
enable
precise
control
over
nanostructure
morphology,
composition,
surface
chemistry.
critically
evaluates
analytical
different
systems
specific
metabolites,
considering
factors
such
as
sensitivity,
selectivity,
stability.
address
challenges
associated
with
SERS-based
sample
preparation,
matrix
effects,
data
interpretation.
Innovative
solutions,
integration
microfluidic
devices
machine
learning
algorithms
spectral
highlighted.
potential
advanced
platforms
point-of-care
diagnostics
personalized
medicine
is
along
future
perspectives
wearable
sensors
multi-modal
analysis
techniques.
comprehensive
overview
provides
insights
into
current
state
directions
technology
detection,
emphasizing
its
to
revolutionize
non-invasive
health
monitoring
disease
diagnosis.
ACS Sustainable Chemistry & Engineering,
Год журнала:
2024,
Номер
12(8), С. 3234 - 3242
Опубликована: Фев. 13, 2024
Flexible
surface-enhanced
Raman
spectroscopy
(SERS)
substrates
have
garnered
more
and
attention
due
to
their
noninvasive
sample
collection
ability.
However,
the
improvement
of
SERS
performance
gradually
reaches
a
bottleneck
with
numerous
studies
on
exploration
active
materials.
In
this
study,
we
constructed
an
Ag@TiO2@cotton
substrate
randomly
distributed
TiO2
nanocavities,
which
can
generate
strong
coupling
cavity
mode,
thus
dramatically
enhancing
activities.
The
prepared
demonstrate
high
detection
sensitivity,
limit
10–10
M
for
MB
solution,
impressive
enhancement
factor
(EF)
2.7
×
108,
excellent
signal
reproducibility,
remarkable
stability.
Furthermore,
proposed
material
allows
sensitive
MG
1.0
through
wiping
fish
method.
These
flexible
expand
range
available
substrates,
easy
fabrication
method
long-term
sensitivity
hold
promise
trace
analysis
harmful
substances.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 23, 2025
Abstract
Kidney
diseases,
posing
significant
global
public
health
challenges
due
to
their
complex
pathogenesis
and
diagnostic/therapeutic
difficulties,
have
seen
emerging
advancements
through
nanomedicine.
In
diagnostics,
nanoparticles
leverage
unique
physicochemical
properties
enhance
imaging
precision.
Superparamagnetic
iron
oxide
improve
magnetic
resonance
sensitivity
by
amplifying
T
2
‐weighted
contrast,
while
microbubbles/nanobubbles
ultrasound
resolution
via
signal
reflection.
Quantum
dots
gold
optimize
photoacoustic
with
superior
fluorescence
photostability.
Therapeutically,
nanoparticle‐based
drug
delivery
systems
demonstrate
targeted
delivery,
reduced
systemic
toxicity,
improved
stability
bioavailability
in
preclinical
studies.
Nanocarrier‐integrated
stem
cell
gene
therapies
further
show
potential
repairing
renal
cells
mitigating
kidney
injury.
This
review
systematically
examines
nanomedicine's
dual
diagnostic
therapeutic
roles
compares
strengths
limitations
of
various
nanodelivery
platforms,
addresses
current
clinical
translation.
By
exploring
novel
nanotechnology‐driven
strategies,
it
aims
guide
future
research
toward
effective,
tailored
for
disease
management.
