A Sandwich-Type Photoelectrochemical Sensor Based on Anthocyanin-Sensitized ZnO/P5FIn Heterojunction for the Sensitive Detection of CYFRA21-1
Abstract
The
accurate
and
highly
sensitive
detection
of
the
tumor
marker
CYFRA21-1
is
crucial
for
screening
diagnosing
potential
lung
cancer
patients
with
non-small
cell
(NSCLC).
A
sandwich-type
photoelectrochemical
(PEC)
immunosensor
based
on
a
ZnO/poly(5-formylindole)
(P5FIn)/anthocyanin
heterostructure
was
developed
to
achieve
background-free
CYFRA21-1.
ZnO
good
photovoltaic
properties
combined
narrow
bandgap
P5FIn
form
p-n
type
heterojunction.
This
structure
reduces
recombination
efficiency
electron-hole
pairs,
thereby
enhancing
photocurrent
response
composite.
Anthocyanidins
are
environmentally
friendly
natural
compounds
excellent
antioxidant,
redox
properties,
remarkable
electrochemical
activity.
After
sensitization
by
anthocyanins,
absorption
utilization
visible
light
in
composites
enhanced,
further
improving
PEC
luminescence
materials.
Additionally,
boron
nitride
quantum
dots
(BN
QDs)
Ab2
via
polydopamine
(PDA)
as
secondary
antibody
marker,
its
sensitivity.
sensor
exhibited
linear
range
(LDR)
0.001-100
ng
mL−
1
limit
(LOD)
0.00033
1.
Furthermore,
this
demonstrates
selectivity,
reproducibility,
stability,
well
successful
results
detecting
actual
human
serum
samples.
approach
provides
feasible
method
detection.
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Июнь 20, 2024
Язык: Английский