Controllable tip exposure of ultramicroelectrodes coated by diamond-like carbon via direct microplasma jet for enhanced stability and fidelity in single-cell recording DOI Creative Commons
Jingquan Liu,

Zhiyuan Du,

Qingda Xu

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Сен. 2, 2024

Abstract Precise and long-term electroanalysis at the single-cell level is crucial for accurate diagnosis monitoring of brain diseases. The reliable protection in areas outside signal acquisition points sharp ultramicroelectrode (UME) tips has a significant impact on sensitivity, fidelity, stability intracellular neural recording. However, it difficult existing UMEs to achieve controllable exposure tip functional structure, which affects their ability resist environmental interference shield noise, resulting unsatisfactory signal-to-noise ratio fidelity recordings. To address this issue, we chose dense electrochemically stable diamond-like carbon (DLC) film as UME coating developed method precisely control exposed degree structure by directly fixed-point processing strong site-selectivity good controllability atmospheric microplasma jet. By analyzing interaction between jet tip, well changes removal length microstructure with time, was controlled down submicron scale. Biocompatibility experiments, electrochemical aging tests real-time pH recording experiments have demonstrated that DLC-UME effective processed potential enable detection high-fidelity signals.

Язык: Английский

Applications and Prospects of Micro/nanoelectrodes in Single-cell Imaging and Electrochemical Detection DOI
Xiaoyang Zhang, Ke Huang, Xiangdong Lai

и другие.

TrAC Trends in Analytical Chemistry, Год журнала: 2025, Номер unknown, С. 118161 - 118161

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Controllable tip exposure of ultramicroelectrodes coated by diamond-like carbon via direct microplasma jet for enhanced stability and fidelity in single-cell recording DOI Creative Commons

Zhiyuan Du,

Qingda Xu,

Ye Xi

и другие.

Microsystems & Nanoengineering, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 23, 2025

Abstract Precise and long-term electroanalysis at the single-cell level is crucial for accurate diagnosis monitoring of brain diseases. The reliable protection in areas outside signal acquisition points sharp ultramicroelectrode (UME) tips has a significant impact on sensitivity, fidelity, stability intracellular neural recording. However, it difficult existing UMEs to achieve controllable exposure tip functional structure, which affects their ability resist environmental interference shield noise, resulting unsatisfactory signal-to-noise ratio fidelity recordings. To address this issue, we chose dense electrochemically stable diamond-like carbon (DLC) film as UME coating developed method precisely control exposed degree structure by directly fixed-point processing strong site-selectivity good controllability atmospheric microplasma jet. By analyzing interaction between jet tip, well changes removal length microstructure with time, was controlled down submicron scale. Biocompatibility experiments, electrochemical aging tests real-time pH recording experiments have demonstrated that DLC-UME effective processed potential enable detection high-fidelity signals.

Язык: Английский

Процитировано

0
An Efficient MEMS Microelectrode Array with Reliable Interelectrode Insulation Processes for In Vivo Neural Recording DOI Open Access
Qingda Xu, Longchun Wang,

Ye Xi

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

Abstract Microelectrode arrays, particularly Utah offer irreplaceable advantages in clinical applications and play a crucial role advancing brain‐computer interactions. However, the glass‐fused monolithic structure of arrays limits functional expansion, glass insulation process is complex, costly, time‐intensive. This paper presents microelectrode array with simple time‐saving fabrication process, utilizing low‐resistance silicon borosilicate wafers as electrodes substrates, respectively. The utilization anodic bonding improves production efficiency enhances compatibility. A one‐step static wet etching used to form microneedle morphology further simplify process. Sputtered iridium oxide, electrode interface material, significantly reduces electrochemical impedance, cellular experiments have confirmed its non‐cytotoxicity. Moreover, implantation into primary visual cortex mice has demonstrated ability record vivo electrical signals within 15 days. Movement trajectory demonstrate that exhibit good behavior activities following implantation. bonded (BMEA) presented this work provides universal effective tool for neural recording, prospective multi‐physiological monitoring microelectromechanical system integration.

Язык: Английский

Процитировано

0
An Implantable Nanoelectrode for Simultaneous in-Situ Self-Referencing, Drug Delivery, and Reliable Fixed-Point Recording Within a Single Neuron DOI

Zhiyuan Du,

Qingda Xu,

Ye Xi

и другие.

Опубликована: Янв. 19, 2025

Язык: Английский

Процитировано

0
Implantable Ultrasonic Neural Probe for Programmable Deep Brain Stimulation and in Situ Synchronous Monitoring DOI
Tao Ruan, Longchun Wang, Qi Wang

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Abstract Deep brain stimulation (DBS) plays a crucial role in treating neurological disorders. In addition to being cumbersome, the currently available DBS probes can only stimulate fixed sites without integrated surveillance techniques. However, therapeutic approaches disorders often require targeting and detection of multiple regions or neural pathways. this study, an implantable miniaturized ultrasonic probe (IUNP) capable programmable with situ synchronous monitoring is introduced. The IUNP comprises 3 × piezoelectric micromachined transducer array three recording microelectrodes. Using phased method, it create field at controllable focal point lateral resolution 450 µm. Furthermore, enables 2D imaging simultaneous electrophysiological signal acquisition during stimulation. These results have considerable implications for multifocal neurotherapy, which requires flexible real‐time monitoring.

Язык: Английский

Процитировано

0
A high-density neural probe with novel fan-out strategy for large-scale neural recording DOI
Jiawei Cao, Longchun Wang, Kejun Tu

и другие.

Sensors and Actuators A Physical, Год журнала: 2025, Номер unknown, С. 116767 - 116767

Опубликована: Июнь 1, 2025

Язык: Английский

Процитировано

0
An Opto-electrophysiology Neural Probe with Photoelectric Artifact-Free for Advanced Single-Neuron Analysis DOI
Qingda Xu,

Ye Xi,

Longchun Wang

и другие.

ACS Nano, Год журнала: 2024, Номер 18(36), С. 25193 - 25204

Опубликована: Авг. 28, 2024

Opto-electrophysiology neural probes targeting single-cell levels offer an important avenue for elucidating the intrinsic mechanisms of nervous system using different physical quantities, representing a significant future direction brain–computer interface (BCI) devices. However, highly integrated structure poses challenges to fabrication processes and presence photoelectric artifacts complicates extraction analysis target signals. Here, we propose miniaturized opto-electrophysiology probe electrical recording optical stimulation at single-cell/subcellular level. The design total internal reflection layer addresses that are more pronounced in devices compared conventional implantable BCI Finite element simulations signal tests demonstrate eliminates time domain, which represents breakthrough optoelectrical Our proposed holds substantial potential promoting development vivo developing advanced therapeutic strategies neurological disorders.

Язык: Английский

Процитировано

2
Controllable tip exposure of ultramicroelectrodes coated by diamond-like carbon via direct microplasma jet for enhanced stability and fidelity in single-cell recording DOI Creative Commons
Jingquan Liu,

Zhiyuan Du,

Qingda Xu

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Сен. 2, 2024

Abstract Precise and long-term electroanalysis at the single-cell level is crucial for accurate diagnosis monitoring of brain diseases. The reliable protection in areas outside signal acquisition points sharp ultramicroelectrode (UME) tips has a significant impact on sensitivity, fidelity, stability intracellular neural recording. However, it difficult existing UMEs to achieve controllable exposure tip functional structure, which affects their ability resist environmental interference shield noise, resulting unsatisfactory signal-to-noise ratio fidelity recordings. To address this issue, we chose dense electrochemically stable diamond-like carbon (DLC) film as UME coating developed method precisely control exposed degree structure by directly fixed-point processing strong site-selectivity good controllability atmospheric microplasma jet. By analyzing interaction between jet tip, well changes removal length microstructure with time, was controlled down submicron scale. Biocompatibility experiments, electrochemical aging tests real-time pH recording experiments have demonstrated that DLC-UME effective processed potential enable detection high-fidelity signals.

Язык: Английский

Процитировано

0