Microneedle wearables in advanced microsystems: unlocking next-generation biosensing with AI
TrAC Trends in Analytical Chemistry,
Год журнала:
2025,
Номер
187, С. 118208 - 118208
Опубликована: Фев. 27, 2025
Язык: Английский
Hydrogel‐Forming Microneedles and Applications in Interstitial Fluid Diagnostic Devices
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 19, 2024
Abstract
Hydrogel‐forming
microneedles
are
constructed
from
or
coated
with
polymeric,
hydrophilic
materials
that
swell
upon
insertion
into
the
skin.
Designed
to
dissolve
disintegrate
postinsertion,
these
can
deliver
drugs,
vaccines,
other
therapeutics.
Recent
advancements
have
broadened
their
application
scope
include
collection,
transport,
and
extraction
of
dermal
interstitial
fluid
(ISF)
for
medical
diagnostics.
This
review
presents
a
brief
introduction
characteristics
ISF,
methods
sampling,
critical
assessment
state‐of‐the‐art
in
hydrogel‐forming
ISF
Key
factors
evaluated
including
material
composition,
swelling
behavior,
biocompatibility,
mechanical
strength
necessary
effective
microneedle
performance
collection.
The
also
discusses
successful
examples
assays
sensor
integrations,
highlighting
notable
achievements,
identifying
research
opportunities,
addressing
challenges
potential
solutions.
Despite
predominance
synthetic
hydrogels
reported
technologies
due
favorable
gelation
properties,
there
is
significant
variety
biopolymers
composites
literature.
field
lacks
consensus
on
optimal
material,
fabrication
methods,
though
emerging
evidence
suggests
processing
techniques
utility
Язык: Английский
Insights into preclinical evaluation of dissolvable microarray patches
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
673, С. 125361 - 125361
Опубликована: Фев. 17, 2025
Drug-loaded
dissolvable
microarray
patches
(MAP)
have
gained
significant
attention
due
to
their
patient-friendly,
economical,
and
environmentally
beneficial
attributes.
Despite
extensive
research
advancements,
only
a
limited
number
of
MAP
progressed
clinical
trials.
While
existing
literature
predominantly
covers
the
initial
stages
development
(e.g.,
manufacturing
techniques,
materials,
design),
there
remains
notable
gap
in
examining
an
experimental
design
during
preclinical
evaluation
phase
undertaken
inform
progression
studies.
To
address
this
gap,
we
present
comprehensive
review
factors
influencing
performance
research.
Our
in-depth
analysis
skin
environment
its
implications
vitro
revealed
that
insertion
methodology,
media
used
for
release
permeation
testing,
models
studies,
metabolism
are
key
need
be
considered.
We
critically
assess
current
trends
propose
potential
optimisations
enhance
efficacy
biorelevance
methods
MAP.
Additionally,
vivo
silico
performance,
underscoring
promising
approaches.
This
article
aims
provide
insights
will
facilitate
standardisation
reliable
methodologies
studies
drug-loaded
MAP,
ultimately
advancing
translation.
Язык: Английский
Point-of-care testing: revolutionizing clinical biochemistry using decentralized diagnostics
Journal of Basic and Clinical Physiology and Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
Abstract
Point-of-care
testing
(POCT)
refers
to
decentralized
done
using
complex
but
compact,
portable
devices
that
can
be
near
the
site
at
patient’s
bedside.
These
enable
quick
diagnosis
and
timely
intervention
because
turnaround
time
(TAT)
decreases
with
these
devices.
They
also
operated
by
non-medical
personnel
patients
minimum
expertise
as
are
easy
handle
interpret.
This
increases
patient
awareness
regarding
their
diseases
benefits
doctors
in
giving
more
patient-centered
care.
POCT
require
setup
utilized
even
remote
places.
The
present
review
focuses
on
employed
specifically
clinical
biochemistry,
e.g.,
glucose,
HbA1c,
cardiac
biomarkers,
fertility
tests,
hematological
analysis,
electrolytes,
enzymes,
urine
dipstick
etc.
introductory
delves
into
comprehending
fundamentals
of
technologies,
guidelines,
applications,
advantages,
disadvantages.
It
covers
a
broad
overview
tests
samples
required
process
tests.
compares
pros
cons
over
centralized
laboratory
testing.
aims
emphasize
relevance
its
use
today’s
era,
current
trends
urban
rural
setups,
challenges
faced
field
during
implementation,
potential
areas
improvement
future.
However,
it
is
advisable
seek
references
for
detailed
critical
information
all
specific
topics
given
this
article.
Язык: Английский
Point-of-Care Testing: The Convergence of Innovation and Accessibility in Diagnostics
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 2, 2025
Over
the
years,
evolution
of
point-of-care
testing
(POCT)
has
been
driven
by
technological
advancements
in
materials,
design,
and
artificial
intelligence,
as
well
breakthrough
developments
wearable
technologies.
These
innovations
are
shifting
diagnostics
from
centralized
medical
facilities
to
individual
homes,
meeting
growing
demand
for
personalized
healthcare.
This
Review
explores
recent
binding-based
assay
technologies
over
past
two
focusing
on
platforms
such
traditional
flow
assays
(lateral
vertical
flow),
fully
integrated
microfluidic
devices,
biosensor-integrated
systems
POCT
applications.
It
emphasizes
role
optical
electrochemical
detection
methods,
which
essential
ensuring
sensitivity,
specificity,
reliability
required
a
POCT.
offer
advantages
including
ease
use,
high
diagnostic
accuracy,
rapid
clinical
assessment,
cost-effectiveness
manufacturing
consumables.
Additionally,
highlights
current
challenges
future
perspectives
delivering
healthcare
through
portable
that
operate
sample-in,
result-out
basis.
Язык: Английский
Effectiveness, Surface Treatments, and Modern Trends in the Preparation of Multifunctional Magnetic Nanoparticles for Analytical and Environmental Applications
Royal Society of Chemistry eBooks,
Год журнала:
2025,
Номер
unknown, С. 1 - 29
Опубликована: Май 7, 2025
Applications
of
multifunctional
magnetic
nanoparticles
(MMNPs)
are
numerous
and
include
environmental
analytical
domains.
Because
their
distinct
characteristics
surface
functions,
MMNPs
useful
instruments
for
separation,
biosensing,
imaging
methods.
Their
efficacy,
treatments,
current
trends
examined
in
this
chapter.
With
great
sensitivity
selectivity,
excellent
methods
like
resonance
(MRI).
help
solve
urgent
issues
by
facilitating
pollution
identification,
water
purification,
soil
remediation
applications.
Innovative
synthesis
techniques,
including
green
microfluidic-assisted
fabrication,
the
focus
offer
scalable
sustainable
MMNP
manufacturing.
Furthermore,
several
related
to
cost-effectiveness,
repeatability,
scalability
still
exist
will
require
further
study,
as
has
been
mentioned.
This
chapter
emphasizes
how
important
advancement
sciences
calls
more
research
development
area.
Язык: Английский
Naturally Derived Biomaterial‐Based Microneedles With Microenvironment‐Response Potential for Diabetic Wound Healing
Wound Repair and Regeneration,
Год журнала:
2025,
Номер
33(3)
Опубликована: Май 1, 2025
ABSTRACT
Delayed
wound
healing
and
non‐healing
wounds
are
common
in
diabetic
patients
due
to
the
hostile
microenvironments
complex
pathophysiology
of
wounds.
Addressing
these
challenges
remains
a
significant
concern
for
clinicians
researchers.
Recently,
microneedle
technology
has
emerged
as
an
effective,
minimally
invasive
delivery
system
treating
wounds,
offering
ease
use
efficient
drug
delivery.
Naturally
derived
biomaterial‐based
microneedles
have
demonstrated
excellent
biocompatibility,
degradability,
low
toxicity,
enhancing
process
by
providing
mechanical
support
delivering
antimicrobial
agents,
growth
factors,
antioxidants.
Some
designed
adapt
specific
leading
improved
outcomes.
This
review
summarises
design
development
naturally
discusses
mechanisms
action
response
varying
conditions.
The
also
addresses
critical
considerations
developing
microenvironment‐response
microneedles,
highlighting
implications
translational
medicine.
Collectively,
interdisciplinary
collaboration
technological
innovation
advanced
creation
using
natural
biomaterials,
which
hold
potential
improving
healing.
Язык: Английский
Sweat-Sensing Patches with Integrated Hydrogel Interface for Resting Sweat Collection and Multi-Information Detection
Biosensors,
Год журнала:
2025,
Номер
15(6), С. 342 - 342
Опубликована: Май 29, 2025
Sweat
analysis
represents
an
emerging
non-invasive
approach
for
health
monitoring,
yet
its
practical
application
is
hindered
by
challenges
such
as
insufficient
natural
sweat
secretion
and
inefficient
collection.
To
overcome
these
limitations,
this
study
develops
a
hydrogel
sheet
composed
of
agarose
glycerol,
which
efficiently
facilitates
resting
collection
without
external
stimulation
when
integrated
into
the
microfluidic
channels
sweat-sensing
patch.
The
patch,
fabricated
with
laser-cut
technology,
features
sandwich
structure
that
enables
measurement
rate
chloride
ion
concentration
while
minimizing
interference
from
electrochemical
reactions.
Additionally,
colorimetric
module
utilizing
glucose
oxidase
peroxidase
also
platform
cost-effective
efficient
detection
through
color
change
can
be
quantified
via
RGB
analysis.
interface,
characterized
optimal
thickness
water
content,
exhibits
superior
absorption
capability
retention,
negligible
effect
on
dilution
components.
This
hydrogel-interfaced
demonstrates
high
efficiency
in
multi-biomarker
analysis,
offering
non-invasive,
real-time
solution
monitoring.
Its
low-cost
wearable
design
highlights
potential
broad
applications
personalized
healthcare.
Язык: Английский
I-Motif DNA Based Fluorescent Ratiometric Microneedle Sensing Patch for Sensitive Response of Small pH Variations in Interstitial Fluid
ACS Sensors,
Год журнала:
2024,
Номер
9(12), С. 6563 - 6571
Опубликована: Ноя. 14, 2024
Detection
of
slight
pH
changes
in
skin
interstitial
fluid
(ISF)
is
crucial
yet
challenging
for
studying
pathological
processes
and
understanding
personal
health
conditions.
In
this
work,
we
construct
an
i-motif
DNA
based
fluorescent
ratiometric
microneedle
sensing
patch
(IFR-pH
MN
patch)
strategy
that
enables
minimally
invasive,
high-resolution,
sensitive
transdermal
monitoring
small
variations
ISF.
The
IFR-pH
with
advanced
integration
both
ISF
sampling
was
fabricated
from
the
cross-linking
gelatin
methacryloyl
methacrylated
hyaluronic
acid,
wrapping
pH-sensitive
hairpin-containing
probes
matrix.
Because
it
mechanically
robust
penetration
has
high
swelling
ability,
could
be
quickly
extracted
as
sufficient
liquid
agarose
gel
(∼56.4
μL
10
min).
Benefiting
conformation
under
variation
fluorescence
signal
readout,
quantitate
over
a
range
between
6.2
6.9
accuracy
0.2
units
mimic
model.
Furthermore,
vivo
testing
on
wound
tumor
mouse
models
indicated
ability
biocompatible
to
penetrate
obtaining
values,
demonstrating
potential
applications
intervention
states.
Язык: Английский
Advancements in microneedle technology: current status and next-generation innovations
Journal of Microencapsulation,
Год журнала:
2024,
Номер
41(8), С. 782 - 803
Опубликована: Окт. 30, 2024
Microneedle
technology
is
a
pivotal
component
of
third-generation
transdermal
drug
delivery
systems
featuring
tiny
needles
that
create
temporary
microscopic
channels
in
the
stratum
corneum
which
facilitate
penetration
dermis.
This
review
offers
detailed
examination
current
types
microneedles,
including
solid,
coated,
dissolving,
hollow,
and
swelling
along
with
their
preparation
techniques
as
well
benefits
challenges.
Use
3D
printing
especially
gaining
significant
attention
due
to
its
ability
achieve
high
dimensional
accuracy
required
for
precise
fabrication.
Additionally,
customisability
presents
potential
exploring
new
designs
creating
personalised
microneedles
products.
Furthermore,
this
explores
next
generation
stimuli-responsive
microneedle,
bioinspired
microneedle
combined
other
like
sonophoresis,
electroporation
iontophoresis.
Regulatory
aspects,
characterisation
techniques,
safety
considerations,
cost
factors
have
also
been
addressed
are
crucial
translation
from
lab
market.
Язык: Английский