In
modern
analytical
chemistry,
one
of
the
primary
goals
is
to
develop
miniaturized,
easy-to-use
sensing
tools,
particularly
those
with
multitasking
capabilities.
this
work,
we
designed
a
mini-voltammetric
cell
that
integrates
modified
Au
microelectrode
(Au/Au
NPs
as
working
electrode)
and
an
Ag/AgCl
reference
electrode
installed
within
micropipette
tip.
This
combined
tool
not
only
enables
portable
on-site
microvolume
sampling─requiring
(around
20-40
μL)
or
single
droplet─but
also
facilitates
direct
micro-electroanalysis
in
short
time.
To
evaluate
its
capabilities,
was
optimized
for
trace
analysis
nitrite
ions
demonstrated
linear
responses
ranges
20-150
150-1200
μM,
acceptable
limit
detection
(LOD)
18.40
meeting
both
WHO
EPA
standards
levels.
Furthermore,
it
exhibited
high
selectivity,
stability
(up
36
continuous
measurements
3.24%
signal
drop),
repeatability
(RSD
2.98%,
Biosensors,
Год журнала:
2024,
Номер
14(12), С. 613 - 613
Опубликована: Дек. 13, 2024
Microfluidic
devices
have
revolutionized
biosensing
by
enabling
precise
manipulation
of
minute
fluid
volumes
across
diverse
applications.
This
review
investigates
the
incorporation
machine
learning
(ML)
into
design,
fabrication,
and
application
microfluidic
biosensors,
emphasizing
how
ML
algorithms
enhance
performance
improving
design
accuracy,
operational
efficiency,
management
complex
diagnostic
datasets.
Integrating
microfluidics
with
has
fostered
intelligent
systems
capable
automating
experimental
workflows,
real-time
data
analysis,
supporting
informed
decision-making.
Recent
advances
in
health
diagnostics,
environmental
monitoring,
synthetic
biology
driven
are
critically
examined.
highlights
transformative
potential
ML-enhanced
systems,
offering
insights
future
trajectory
this
rapidly
evolving
field.
Biosensors,
Год журнала:
2025,
Номер
15(1), С. 45 - 45
Опубликована: Янв. 13, 2025
In
this
work,
an
integrated
microfluidic
microwave
array
sensor
is
proposed
for
the
enrichment
and
detection
of
mixed
biological
solution.
individuals
with
urinary
tract
infections
or
intestinal
health
issues,
levels
white
blood
cells
(WBCs)
Escherichia
coli
(E.
coli)
in
urine
extracts
can
be
significantly
elevated
compared
to
normal.
The
chip,
characterized
by
its
low
cost,
simplicity
operation,
fast
response,
high
accuracy,
designed
detect
a
solution
WBCs
E.
coli.
results
demonstrate
that
microfluidics
could
effectively
enrich
efficiency
88.3%.
For
WBC
detection,
resonance
frequency
sensing
chip
decreases
increasing
concentration,
while
capacitance
value
increases
concentration.
Furthermore,
measurement
data
are
processed
using
machine
learning.
Specifically,
subjected
further
linear
fitting.
addition,
prediction
model
employing
four
different
algorithms,
achieves
maximum
accuracy
95.24%.
Consequently,
employed
clinical
diagnosis
coli,
providing
novel
approach
medical
research
involving
bacteria.
The
proposed
Bayesian
optimization-based
approach
enhances
micromixer
performance
by
optimizing
geometric
parameters,
significantly
reducing
required
number
of
simulations,
and
accelerating
the
design
process
compared
to
conventional
methods.
Biosensors,
Год журнала:
2025,
Номер
15(3), С. 189 - 189
Опубликована: Март 15, 2025
This
review
explores
the
development,
technological
foundations,
and
applications
of
biosensor
technologies
across
various
fields,
such
as
medicine
for
disease
diagnosis
monitoring,
food
industry.
However,
primary
focus
is
on
their
use
in
detecting
contaminants
pathogens,
well
environmental
monitoring
water
quality
assessment.
The
classifies
different
types
biosensors
based
bioreceptor
transducer,
highlighting
how
they
are
specifically
designed
detection
emerging
(ECs)
pathogens
water.
Key
innovations
this
technology
critically
examined,
including
advanced
techniques
systematic
evolution
ligands
by
exponential
enrichment
(SELEX),
molecularly
imprinted
polymers
(MIPs),
self-assembled
monolayers
(SAMs),
which
enable
fabrication
sensors
with
improved
sensitivity
selectivity.
Additionally,
integration
microfluidic
systems
into
analyzed,
demonstrating
significant
enhancements
performance
speed.
Through
these
advancements,
work
emphasizes
fundamental
role
key
tools
safeguarding
public
health
preserving
integrity.
Abstract
The
integration
of
conductive
biological
materials
into
in
vitro
models
represents
a
transformative
approach
to
advancing
biomedical
research
while
addressing
critical
sustainability
challenges.
Traditional
used
tissue
engineering
and
disease
modeling
are
often
environmentally
detrimental,
derived
from
non-renewable
resources,
limited
their
ability
replicate
the
dynamic
properties
native
tissues.
Conductive
bridge
this
gap
by
offering
unique
combination
biodegradability,
sustainability,
functional
properties,
such
as
bioelectricity
biocompatibility,
that
essential
for
mimicking
physiological
environments.
Herein,
development
current
applications
biodegradable
materials,
including
advanced
polymers
polyaniline
polypyrrole,
carbon-based
nanocomposites,
renewable
biopolymers
lignin
cellulose,
overviewed.
These
not
only
reduce
ecological
footprint
but
also
enable
precise
simulation
electrical
signaling
tissues,
cardiac,
neural,
muscular
systems,
thereby
enhancing
relevance
models.
Their
three-dimensional
(3D)
constructs,
organ-on-chip
platforms,
bioprinting
technologies
facilitates
patient-specific
models,
paving
way
personalized
therapeutic
diagnostic
applications.
In
addition
precision,
these
align
with
global
efforts
implement
circular
economy
principles
research,
promoting
resource
efficiency
waste
reduction.
By
combining
environmental
responsibility
state-of-the-art
functionality,
redefining
future
3D
accelerating
innovation
regenerative
medicine,
drug
development,
fostering
sustainable
framework
scientific
discovery.
