A Novel Tumor on Chip Mimicking the Breast Cancer Microenvironment for Dynamic Drug Screening

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1028 - 1028

Опубликована: Янв. 25, 2025

In light of the emerging breakthroughs in cancer biology, drug discovery, and personalized medicine, Tumor-on-Chip (ToC) platforms have become pivotal tools current biomedical research. This study introduced a novel rapid prototyping approach for fabrication ToC device using laser-patterned poly(methyl methacrylate) (PMMA) layers integrated with polylactic acid (PLA) electrospun scaffold, enabling dynamic delivery assessment therapeutic efficacy cells. Traditional screening methods, such as conventional cell cultures, mimic certain aspects progression but fail to capture critical features tumor microenvironment (TME). While animal models offer closer approximation complexity, they are limited their ability predict human responses. Here, we evaluated our recapitulate interactions between TME cells its evaluating response breast The functional design proposed system offered substantial potential wide range applications research, significantly accelerating preclinical new agents.

Язык: Английский

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Revolutionizing Drug Discovery: The Impact of Distinct Designs and Biosensor Integration in Microfluidics-Based Organ-on-a-Chip Technology

Biosensors, Год журнала: 2024, Номер 14(9), С. 425 - 425

Опубликована: Сен. 3, 2024

Traditional drug development is a long and expensive process with high rates of failure. This has prompted the pharmaceutical industry to seek more efficient frameworks, driving emergence organ-on-a-chip (OOC) based on microfluidic technologies. Unlike traditional animal experiments, OOC systems provide accurate simulation human organ microenvironments physiological responses, therefore offering cost-effective platform for biomedical research, particularly in new medicines. Additionally, enable quick real-time analysis, high-throughput experimentation, automation. These advantages have shown significant promise enhancing process. The success an system hinges integration specific designs, manufacturing techniques, biosensors meet need integrated multiparameter datasets. review focuses manufacturing, design, sensing systems, applications highlighting their design capabilities, as well technical challenges they currently face.

Язык: Английский

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Bone-on-a-Chip Systems for Hematological Cancers

Biosensors, Год журнала: 2025, Номер 15(3), С. 176 - 176

Опубликована: Март 9, 2025

Hematological malignancies originating from blood, bone marrow, and lymph nodes include leukemia, lymphoma, myeloma, which necessitate the use of a distinct chemotherapeutic approach. Drug resistance frequently complicates their treatment, highlighting need for predictive tools to guide therapeutic decisions. Conventional 2D/3D cell cultures do not fully encompass in vivo criteria, translating disease models mice humans proves challenging. Organ-on-a-chip technology presents an avenue surmount genetic disparities between species, offering precise design, concurrent manipulation various types, extrapolation data human physiology. The development bone-on-a-chip (BoC) systems is crucial accurately representing microenvironment, predicting drug responses hematological cancers, mitigating resistance, facilitating personalized interventions. BoC modeling cancers research can intricate designs integrated platforms analyzing response simulate scenarios. This review provides comprehensive examination applicable visualizing within context bone. It thoroughly discusses materials pertinent systems, suitable vitro techniques, capabilities clinical settings, potential commercialization.

Язык: Английский

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How organ-on-a-chip is advancing cancer research and oncology - a cancer hallmarks’ perspective

Frontiers in Lab on a Chip Technologies, Год журнала: 2024, Номер 3

Опубликована: Ноя. 19, 2024

Despite significant improvements in methodologies behind the development of new anticancer therapies, path from early-stage drug through preclinical and clinical pipeline is still arduous. Further refinement current models complementing alternative techniques that enable more reliable studies are paramount. The emerging organ-on-a-chip (OoC) technologies physiological-like organ biomimetic systems built on a microfluidic chip, capable enabling precise control over various physicochemical biomechanical parameters helping recreate natural physiology mechanical forces cells experience human body. In oncology research, especially, since cancer has been understood to be dynamic disease featured by complex interactions between their environment, this technology offers added advantage as it able provide platform simulate cancer-on-a-chip emulating biological context tumor microenvironment (TME); demonstrating progression metastases multiorgans; unravel information other vitro methods otherwise not provide. contribution, we perspective recent advances field OoC biology hallmark perspective. We also discuss prospects funding opportunities space, well possible future outlook perspective, including major challenges way forward technologies.

Язык: Английский

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Dimension compensation of printed master molds by a desktop LCD 3D printer for high-precision microfluidic applications

Microchimica Acta, Год журнала: 2024, Номер 191(10)

Опубликована: Сен. 9, 2024

Язык: Английский

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Bridging the Gap: From Petri Dish to Patient - Advancements in Translational Drug Discovery

Heliyon, Год журнала: 2024, Номер 11(1), С. e41317 - e41317

Опубликована: Дек. 18, 2024

Язык: Английский

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Dimension compensation of desktop LCD 3D printer for high-precision microfluidic applications

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июнь 28, 2024

Recent advances in low-cost liquid crystal display (LCD) 3D printing have popularized its use creating microfluidic master molds and complete devices. However, the quality precision of these fabrications often fall short rigorous standards required for advanced applications. This study introduces a novel approach to enhance dimensional accuracy microchannels produced using desktop LCD printer. We propose method dimension compensation, optimize parameters, provide straightforward post-treatment technique ensure high-quality curing polydimethylsiloxane (PDMS) made from photosensitive resin. Our investigation assesses across three different scales square cross-section by measuring their widths heights, leading determination optimal layer thicknesses that minimize fabrication errors. The errors are further reduced introducing series compensation factors, which correct nominal dimensions factors printing. is significantly improved after even fabricating complex triangular cross-sections. Finally, spiral channel trapezoidal-like with tilted edges fabricated application, highly efficient particle separation realized channel. proposed provides new insights utilizing printers achieve high-accuracy microstructures necessary

Язык: Английский

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Opportunities for Microphysiological Systems from the View of Japanese Industries

Drug Metabolism and Pharmacokinetics, Год журнала: 2024, Номер 60, С. 101034 - 101034

Опубликована: Ноя. 9, 2024

Язык: Английский

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