Marine Drugs,
Год журнала:
2023,
Номер
21(3), С. 166 - 166
Опубликована: Март 4, 2023
Triple-negative
breast
cancer
(TNBC)
represents
an
aggressive
subtype
of
(BC)
with
a
typically
poorer
prognosis
than
other
subtypes
BC
and
limited
therapeutic
options.
Therefore,
new
drugs
would
be
particularly
welcome
to
help
treat
TNBC.
Preussin,
isolated
from
the
marine
sponge-associated
fungus,
Aspergillus
candidus,
has
shown
potential
reduce
cell
viability
proliferation
as
well
induce
death
cycle
arrest
in
2D
culture
models.
However,
studies
that
better
mimic
tumors
vivo,
such
3D
cultures,
are
needed.
Here,
we
studied
effects
preussin
MDA-MB-231
line,
comparing
using
ultrastructural
analysis
MTT,
BrdU,
annexin
V-PI,
comet
(alkaline
FPG
modified
versions),
wound
healing
assays.
Preussin
was
found
decrease
viability,
both
dose-dependent
manner,
impair
proliferation,
death,
therefore
excluding
hypothesis
genotoxic
properties.
The
cellular
impacts
were
reflected
by
alterations
also
significantly
inhibited
migration
cells.
data
expanded
knowledge
on
actions
while
supporting
studies,
highlighting
its
molecule
or
scaffold
for
development
anticancer
against
Frontiers in Marine Science,
Год журнала:
2022,
Номер
9
Опубликована: Фев. 10, 2022
The
marine
environment
is
a
relatively
unexplored
source
of
functional
ingredients
that
can
be
used
in
food
processing,
storage,
and
fortification
variety
ways.
Marine
microorganisms
are
possible
novel
bioactive
chemicals
with
potential
human
utility.
Some
these
microbes
live
the
harsh
environments,
resulting
complex
compounds
unique
biological
properties
several
industrial
biotechnological
applications.
So
far,
(fungi,
myxomycetes,
bacteria,
microalgae)
have
been
isolated
produce
antioxidant,
antibacterial,
apoptotic,
antitumoral,
antiviral
chemicals.
Furthermore,
it
emphasizes
enormous
for
to
very
important
main
goal
this
review
provide
concise
overview
constituents
bioactives.
Anticoagulant,
anticancer,
hypocholesterolemic
effects
demonstrated
peptides
extracted
from
fish
protein
hydrolysates,
as
well
algal
fucans,
galactans,
alginates.
omega-3
fatty
acids
abundant
oils
microorganisms,
while
potent
antioxidants
such
carotenoids
phenolic
found
crustaceans
seaweeds.
This
focuses
on
use
marine-derived
health
maintenance
chronic
disease
prevention,
based
their
qualities.
Encyclopedia,
Год журнала:
2022,
Номер
2(1), С. 559 - 577
Опубликована: Фев. 28, 2022
Marine
fungi
play
a
crucial
role
in
energy
flow
and
nutrient
recycling,
mediating
the
cycling
of
dissolved
organic
matter
marine
environments.
However,
despite
being
prolific
group
organisms,
have
been
largely
neglected
for
long
time.
Besides
their
importance
food
web,
represent
an
active
source
natural
products.
Over
last
years,
researchers
focused
on
studying
organisms
to
discover
new
metabolites
with
antibacterial,
antiviral,
anticancer
activities.
Moreover,
advances
high-throughput
sequencing
technologies
mass
spectrometry
techniques,
genomic
metabolomic
approaches
revealed
be
paramount
products
discovery.
The
mycobiome
includes
many
still
identified,
ones
already
known
are
underutilized
biotechnological
applications.
For
this
reason,
it
is
undeniable
that
exploring
including
habitats
substrates,
even
those
remote
access,
fundamental
describing
true
magnitude
Earth’s
mycobiome.
Pharmaceuticals,
Год журнала:
2022,
Номер
15(12), С. 1471 - 1471
Опубликована: Ноя. 26, 2022
Cancer
is
a
serious
threat
to
human
beings
and
the
second-largest
cause
of
death
all
over
globe.
Chemotherapy
one
most
common
treatments
for
cancer;
however,
drug
resistance
severe
adverse
effects
are
major
problems
associated
with
anticancer
therapy.
New
compounds
multi-target
inhibitory
properties
targeted
surmount
these
challenges.
Cyclooxygenase-2
(COX-2)
overexpressed
in
cancers
pancreas,
breast,
colorectal,
stomach,
lung
carcinoma.
Therefore,
COX-2
considered
significant
target
synthesis
new
agents.
This
review
discusses
biological
activity
recently
prepared
dual
The
important
intermolecular
interactions
enzyme
have
also
been
presented.
Analysis
agents
active
area
could
guide
introduction
lead
extreme
selectivity
minor
side
effects.
Marine Drugs,
Год журнала:
2023,
Номер
21(2), С. 120 - 120
Опубликована: Фев. 11, 2023
Depsipeptides,
an
important
group
of
polypeptides
containing
residues
hydroxy
acids
and
amino
linked
together
by
amide
ester
bonds,
have
potential
applications
in
agriculture
medicine.
A
growing
body
evidence
demonstrates
that
marine
organisms
are
prolific
sources
depsipeptides,
such
as
cyanobacteria,
sponges,
mollusks,
microorganisms
algae.
However,
these
substances
not
yet
been
comprehensively
summarized.
In
order
to
enrich
our
knowledge
about
their
biological
structural
features,
well
bioactivities,
highlighted
this
review
after
extensive
literature
search
data
analysis.
Marine Drugs,
Год журнала:
2023,
Номер
21(3), С. 193 - 193
Опубликована: Март 21, 2023
Cardiovascular
diseases
(CVDs)
are
among
the
most
impactful
illnesses
globally.
Currently,
available
therapeutic
option
has
several
side
effects,
including
hypotension,
bradycardia,
arrhythmia,
and
alteration
in
different
ion
concentrations.
Recently,
bioactive
compounds
from
natural
sources,
plants,
microorganisms,
marine
creatures,
have
gained
a
lot
of
interest.
Marine
sources
serve
as
reservoirs
for
new
metabolites
with
various
pharmacological
activities.
The
marine-derived
compound
such
omega-3
acid
ethyl
esters,
xyloketal
B,
asperlin,
saringosterol
showed
promising
results
CVDs.
present
review
focuses
on
compounds’
cardioprotective
potential
hypertension,
ischemic
heart
disease,
myocardial
infarction,
atherosclerosis.
In
addition
to
alternatives,
current
use
components,
future
trajectory,
restrictions
also
reviewed.
Food Chemistry X,
Год журнала:
2022,
Номер
15, С. 100444 - 100444
Опубликована: Сен. 9, 2022
The
gut
microbiota
dysbiosis
is
a
state
which
the
physiological
combinations
of
flora
are
transformed
into
pathological
caused
by
factors
such
as
diets,
pollution,
and
drugs.
Increasing
evidence
shows
that
closely
related
to
many
diseases.
With
continuous
development
utilization
marine
resources,
polysaccharides
have
been
found
regulate
in
studies.
In
this
review,
we
introduce
types
degree
it
different
factors.
We
highlight
regulating
effects
on
potential
prebiotic.
mechanisms
including
protection
intestinal
barrier,
regulatory
effect
microbiota,
alteration
for
metabolites,
some
other
possible
were
summarized.
And
aim
provide
references
high-value
new
targets
treatment
review.
Marine Drugs,
Год журнала:
2023,
Номер
21(10), С. 524 - 524
Опубликована: Сен. 30, 2023
Inflammation
is
a
defense
mechanism
of
the
body
in
response
to
harmful
stimuli
such
as
pathogens,
damaged
cells,
toxic
compounds
or
radiation.
However,
chronic
inflammation
plays
an
important
role
pathogenesis
variety
diseases.
Multiple
anti-inflammatory
drugs
are
currently
available
for
treatment
inflammation,
but
all
exhibit
less
efficacy.
This
drives
search
new
focusing
on
natural
resources.
Marine
organisms
produce
broad
spectrum
bioactive
with
activities.
Several
considered
lead
development
into
drugs.
Anti-inflammatory
have
been
extracted
from
algae,
corals,
seaweeds
and
other
marine
organisms.
We
previously
reviewed
compounds,
well
crude
extracts
isolated
echinoderms
sea
cucumbers,
urchins
starfish.
In
present
review,
we
evaluate
effects
organisms,
including
macroalgae
(seaweeds),
angiosperms
(seagrasses),
medusozoa
(jellyfish),
bryozoans
(moss
animals),
mollusks
(shellfish)
peanut
worms.
also
review
molecular
mechanisms
activity
these
compounds.
Our
objective
this
provide
overview
current
state
research
sources
prospects
their
translation
novel
Environmental Chemistry Letters,
Год журнала:
2024,
Номер
22(4), С. 2133 - 2149
Опубликована: Апрель 27, 2024
Abstract
The
rising
number
of
diseases
and
deaths
caused
by
pollution
modern
lifestyle
habits
is
a
growing
societal
concern.
Marine
ecosystems
are
both
victim
to
this
human
behaviour
as
recipient
well
being
source
medicinal
chemicals
which
can
cure
variety
diseases.
In
paper,
we
review
the
chemical
basis
water-based
treatments
their
effects
on
health,
while
focusing
threats
marine
potential
benefits
balneotherapy,
thalassotherapy,
bioactive
species.
We
found
that
seawater
has
for
skin
demonstrating
emollient
properties,
protection
against
barrier
disruption,
inhibition
atopic
dermatitis-like
lesions.
present
putative
mechanisms
minerals,
salts,
organic
matter
slow
down
disease
progression,
through
numerous
activities,
such
anti-inflammatory,
antioxidant,
wound
healing
properties.
Water-living
organisms
also
have
an
impact
producing
biologically
active
compounds
with
beneficial
health.
