Abstract
Background
The
use
of
plant
extracts
as
antibiotics
is
gaining
more
attention
because
bacteria
are
one
the
biggest
threats
to
global
health
and
resistance
in
humans
animals
increasing.
Antibacterial
susceptibility
used
determine
which
specific
a
particular
bacterium
sensitive
to.
This
research
focused
on
phytochemical,
vitro
antibacterial
susceptibility,
silico
analysis
Morinda
lucida
root
against
gram-negative
Pseudomonas
aeruginosa
gram-positive
Staphylococcus
aureus
.
M.
was
extracted
separately
with
ethanol,
chloroform,
ethyl
acetate.
Results
Crude
had
active
activity
were
promising
natural
antibiotic
when
compared
gentamicin.
results
showed
that
good
properties
two
drug-resistant
while
2-hydroxy-1-methoxy
anthraquinone
predicted
have
better
S.
alizarin
has
P.
aeruginosa.
Finally,
MD
simulation
studies
Alizarin
9,10-Anthracenedione
2-hydroxy-1-
methoxy-
define
stability
protein–ligand
complexes
within
50
ns
time
scale.
Antibiotics,
Год журнала:
2023,
Номер
12(2), С. 228 - 228
Опубликована: Янв. 20, 2023
Photodynamic
Antimicrobial
Chemotherapy
(PACT)
has
received
great
attention
in
recent
years
since
it
is
an
effective
and
promising
modality
for
the
treatment
of
human
oral
skin
infections
with
advantage
bypassing
pathogens’
resistance
to
antimicrobials.
Moreover,
PACT
applications
demonstrated
a
certain
activity
inhibition
eradication
biofilms,
overcoming
well-known
tolerance
sessile
communities
antimicrobial
agents.
In
this
study,
13
diaryl-porphyrins
(mono-,
di-cationic,
non-ionic)
P1–P13
were
investigated
their
potential
as
photosensitizer
anti-Staphylococcus
aureus.
The
efficacy
was
evaluated
through
photo-inactivation
tests.
Crystal-violet
staining
combined
viable
count
techniques
aimed
at
assaying
anti-biofilm
activity.
Among
tested
compounds,
neutral
P4
better
than
cationic
ones,
irrespective
corresponding
binding
rates.
particular,
active
inhibiting
biofilm
formation
impairing
viability
adherent
planktonic
populations
24
h
old
biofilm.
inhibitory
also
efficient
against
methicillin
resistant
S.
aureus
strain.
conclusion,
diaryl-porphyrin
family
represents
reservoir
compounds
photodynamic
pathogen
preventing
biofilms
that
cause
many
become
chronic.
Advances in chemical and materials engineering book series,
Год журнала:
2024,
Номер
unknown, С. 231 - 270
Опубликована: Фев. 27, 2024
Offering
unprecedented
opportunities
to
revolutionize
healing
and
healthcare,
this
chapter
delves
into
the
cutting-edge
advancements
in
nanocoatings
tailored
specifically
for
medicinal
applications,
presenting
a
comprehensive
overview
of
their
potential
enhance
processes
improve
health
outcomes.
A
major
focus
is
on
multifaceted
roles
contexts.
These
include
drug
delivery
systems,
wound
healing,
antimicrobial
coatings,
tissue
engineering
scaffolds,
among
others.
Furthermore,
it
discusses
challenges
regulatory
considerations
associated
with
integration
clinical
practice.
By
exploring
latest
research
findings,
provides
valuable
insights
how
are
poised
transform
landscape
applications.
It
underscores
processes,
mitigate
health-related
challenges,
pave
way
healthier
future.
Advances in bioinformatics and biomedical engineering book series,
Год журнала:
2024,
Номер
unknown, С. 208 - 245
Опубликована: Март 4, 2024
Orthopedic
implants
are
a
boon
for
devastating
bone
diseases
such
as
osteoarthritis
and
fractures.
However,
implantation
of
an
orthopedic
device
is
associated
with
the
risk
bacterial
biofilm
formation
on
surface
implant.
Treating
biofilm-associated
infections
extremely
challenging
owing
to
acidic
environment,
enzymatic
degradation,
presence
sessile
cells,
hypoxic
environment
in
biofilm.
Biofilms
highly
resistant
both
antibacterials
human
immune
system.
Present
antibiotic
therapies
have
limited
success
due
low
blood
flow,
high
density,
poor
permeability
causing
insufficient
permeation
antibiotic.
Nanoparticles
surface-to-volume
ratio
superior
penetration
across
cell
membranes,
their
nanostructure
provides
flexibility
designing
effective
strategies
tackle
infection.
This
chapter
summarizes
various
research
endeavours
which
nanoparticles
been
explored
prevention
or/treatment
biofilms
implants.
Abstract
Background
The
use
of
plant
extracts
as
antibiotics
is
gaining
more
attention
because
bacteria
are
one
the
biggest
threats
to
global
health
and
resistance
in
humans
animals
increasing.
Antibacterial
susceptibility
used
determine
which
specific
a
particular
bacterium
sensitive
to.
This
research
focused
on
phytochemical,
vitro
antibacterial
susceptibility,
silico
analysis
Morinda
lucida
root
against
gram-negative
Pseudomonas
aeruginosa
gram-positive
Staphylococcus
aureus
.
M.
was
extracted
separately
with
ethanol,
chloroform,
ethyl
acetate.
Results
Crude
had
active
activity
were
promising
natural
antibiotic
when
compared
gentamicin.
results
showed
that
good
properties
two
drug-resistant
while
2-hydroxy-1-methoxy
anthraquinone
predicted
have
better
S.
alizarin
has
P.
aeruginosa.
Finally,
MD
simulation
studies
Alizarin
9,10-Anthracenedione
2-hydroxy-1-
methoxy-
define
stability
protein–ligand
complexes
within
50
ns
time
scale.
