International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139220 - 139220
Опубликована: Дек. 1, 2024
Язык: Английский
iScience, Год журнала: 2024, Номер 27(12), С. 111339 - 111339
Опубликована: Ноя. 7, 2024
As the global population continues to grow, so does demand for longer, healthier lives and environmentally responsible choices. Consumers are increasingly drawn naturally sourced products with proven health wellbeing benefits. The marine environment presents a promising yet underexplored resource cosmetics industry, offering bioactive compounds potential safe biocompatible ingredients. This manuscript provides comprehensive overview of organisms production, highlighting marine-derived their applications in skin/hair/oral-care products, cosmeceuticals more. It also lays down critical safety considerations addresses methodologies sourcing compounds, including harvesting, biorefinery concept, use systems biology enhanced product development, relevant regulatory landscape. review is enriched by three case studies: design macroalgal skincare Iceland, establishment microalgal spin-off Italy, utilization proteins cosmeceutical applications.
Язык: Английский
Процитировано
6
Plants, Год журнала: 2025, Номер 14(7), С. 985 - 985
Опубликована: Март 21, 2025
Plant-derived biopesticides are emerging as a promising and popular alternative for promoting cleaner safer agricultural practices. The present work aims to explore Argyranthemum frutescens (Asteraceae) source of botanical pesticides validate this through cultivation process. To task, bioassay-guided fractionation the ethanolic root extracts from both wild cultivated A. on phytopathogenic fungi Botrytis cinerea, Fusarium oxysporum, Alternaria alternata was conducted. This approach led identification polyacetylenes with higher potency than commercial fungicides. Specifically, compounds 3 (capillin) 5 (frutescinone) showed more 90% growth inhibition at 0.05 mg/mL concentration B. while 2 (capillinol) were also active positive controls, Fosbel-Plus Azoxystrobin, against F. oxysporum. structures isolated (1-6, 9, 10) alkamides (7, 8, 11) determined spectroscopic analysis, absolute configuration stereocenter C1 1, 2, 4 9 by NMR-spectroscopy (R)-(-)-α-methoxy-phenylacetic chiral derivatizing agent, biogenetic considerations. Overall, study supports potential agrochemical lead phytopathogens, validates viable biopesticides.
Язык: Английский
Процитировано
0
Heliyon, Год журнала: 2025, Номер 11(4), С. e42594 - e42594
Опубликована: Фев. 1, 2025
Dengue fever is a viral disease caused by the dengue flavivirus and transmitted through mosquito bites in humans. According to World Health Organization, severe causes approximately 40,000 deaths annually, nearly 4 billion people are at risk of infection. The urgent need for effective treatments against virus has led extensive research on potential bioactive compounds. In this study, we utilized network pharmacology approach identify DENV-2 capsid protein as an appropriate target intervention. Subsequently, selected library 537 phytochemicals derived from Azadirachta indica (Family: Meliaceae), known their anti-dengue properties, explore inhibitors protein. compound was subjected molecular docking potent with high binding affinity. We 81 hits based thorough analysis affinities, particularly those exhibiting higher energy than established inhibitor ST-148. After evaluating characteristics, identified two top-scored compounds them dynamics simulations assess stability properties. Additionally, predicted ADMET properties using silico methods. One inhibitors, [(5S,7R,8R,9R,10R,13R,17R)-17-[(2R)-2-hydroxy-5-oxo-2H-furan-4-yl]-4,4,8,10,13-pentamethyl-3-oxo-5,6,7,9,11,12,16,17-octahydrocyclopenta[a]phenanthren-7-yl] acetate (AI-59), showed highest affinity -10.4 kcal/mol. Another compound, epoxy-nimonol (AI-181), demonstrated number H-bonds score -9.5 During simulation studies, both have exhibited noteworthy outcomes. Through mechanics employing Generalized Born surface area (MM/GBSA) calculations, AI-59 AI-181 displayed negative ΔG_bind scores -74.99 -83.91 kcal/mol, respectively. hit present investigation hold developing drugs targeting infections. Furthermore, knowledge gathered study serves foundation structure- or ligand-based exploration
Язык: Английский
Процитировано
0
Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 373 - 373
Опубликована: Март 6, 2025
The skin is one of the largest and most important organs our body. There are numerous factors that related to health, including lifestyle factors, nutrition, or care. Bioactive substances from plant marine extracts play a key role in health. aim this research was compile main evidence on bioactive substances. An integrative review performed, reporting findings according PRISMA (2020). Thirteen search equations were developed. After applications process screening selection articles, 95 references compiled. results compounds classified into food-derived components, nutraceuticals, symbiotics, active origin, extracts). several indicate use interesting for highlighting some dietary nutrients, obtained metabolites origin that, showing anti-inflammatory antimicrobial effects, improvement conditions principles cosmetics.
Язык: Английский
Процитировано
0
Toxicology International, Год журнала: 2025, Номер unknown, С. 129 - 138
Опубликована: Март 12, 2025
The toxic properties of newly synthesized vinylphosphonates, namely, diene compounds with ethyl and isopropyl substituents in the phosphonate group were examined this study. Previous studies have revealed laser-induced cistrans isomerization these compounds. In addition, high biological activity vinylphosphonates its significant dependence on photoirradiation been found. proven possibility controlling phosphonates under laser irradiation opens prospects for applying them photopharmacology producing drugs capability remote precise control over area duration their therapeutic effect. Due to promising application photopharmacology, relevant task first stages research was ascertaining effects toxicity substances, including daphnia, ciliates, unicellular green algae, tested using a bioassay system. Considering insolubility water, experiments carried out after preliminary dissolution dichloromethane at harmless concentration water selected test organisms. Major Findings: Based results obtained, toxicological parameters calculated lethal LC50 (0.2×10-5 M/L) effective EC50 (3.3 × 10-5 M/L), as well no observed effect NOEC (0.9 10-6 which do not cause statistically Daphnia most sensitive phosphonates.
Язык: Английский
Процитировано
0
Frontiers in Chemistry, Год журнала: 2024, Номер 12
Опубликована: Июль 25, 2024
Biofouling poses a significant economic threat to various marine industries, leading financial losses that can reach billions of euros annually. This study highlights the urgent need for effective alternatives traditional antifouling agents, particularly following global ban on organotin compounds.
Язык: Английский
Процитировано
3
Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12
Опубликована: Авг. 22, 2024
Introduction Marine environments offer a wealth of opportunities to improve understanding and treatment options for cancers, through insights into range fields from drug discovery mechanistic insights. By applying One Health principles the knowledge obtained can benefit both human animal populations, including marine species suffering cancer. such is green sea turtles ( Chelonia mydas ), which are under threat fibropapillomatosis (FP), an epizootic tumor disease (animal epidemic) that continues spread increase in prevalence globally. In order effectively address this epizootic, more thorough required approaches treating afflicted turtles. Methods To identify gaps assess future needs, we conducted survey turtle FP experts. The consisted 47 questions designed general perceptions FP, areas where information needed, local trends, status, mitigation was voluntarily completed by 44 experts across broad geographic range. Results Over 70% respondents recognized as cancerous panzootic disease, reported increasing prevalence. They report several factors contributing increase. Nearly all research, patient rehabilitation funding their area, inadequate facilities capacity dealing with patients. Treatment varied: just over medical responded surgically remove tumors, either using laser or scalpel. Just half use anti-cancer drugs FP. Internal tumors were justification euthanasia 61.5% respondents, 30.8% severe external be sufficient grounds euthanasia. Most (93.3%) routinely perform necropsy on deceased euthanized FP-afflicted 80% considered large-scale multidisciplinary collaboration ‘extremely important’ advancing field research. Discussion responses provide valuable insight current status turtles, treatment, help critical FP-related most need attention.
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Июнь 7, 2024
Abstract Marine environments offer a wealth of opportunities to improve understanding and treatment options for cancers, through insights into range fields from drug discovery mechanistic insights. By applying One Health principles the knowledge obtained can benefit both human animal populations, including marine species suffering cancer. such is green sea turtles ( Chelonia mydas ), which are under threat fibropapillomatosis (FP), an epizootic tumor disease (animal epidemic) that continues spread increase in prevalence globally. In order effectively address this epizootic, more thorough required approaches treating afflicted turtles. To identify gaps assess future needs, we conducted survey turtle FP experts. The consisted 47 questions designed general perceptions FP, areas where information needed, local trends, status, mitigation was voluntarily completed by 44 experts across broad geographic range. responses provided valuable overview current status turtles, research, insight currently taken rehabilitation facilities around world. Over 70% respondents recognized as cancerous panzootic disease, reported increasing prevalence. They report several factors contributing increase. Nearly all patient funding their area, inadequate capacity dealing with patients. Treatment varied: just over medical responded surgically remove tumors, either using laser or scalpel. Just half use anti-cancer drugs FP. Internal tumors were justification euthanasia 61.5% respondents, 30.8% severe external be sufficient grounds euthanasia. Most (93.3%) routinely perform necropsy on deceased euthanized FP-afflicted 80% considered large-scale multidisciplinary collaboration ‘extremely important’ advancing field research. provide state treatment, help critical FP-related research most need attention.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139220 - 139220
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0