Global Advancements in Bioactive Material Manufacturing for Drug Delivery: A Comprehensive Study
ACS Omega,
Год журнала:
2025,
Номер
10(1), С. 1207 - 1225
Опубликована: Янв. 3, 2025
Manufacturing
bioactive
materials
for
drug
delivery
involves
developing
that
interact
with
biological
tissues
to
release
drugs
in
a
controlled
and
targeted
manner.
The
goal
is
optimize
therapeutic
efficacy
reduce
side
effects
by
combining
knowledge
from
engineering,
biology,
pharmacology.
This
study
presents
detailed
bibliometric
analysis,
exploring
the
keywords
"manufacturing,"
"bioactive
materials,"
"drug
delivery"
identify
highlight
significant
advancements
field.
From
Web
of
Science,
36,504
articles
were
analyzed,
171
selected
deeper
identifying
key
journals,
countries,
institutions,
authors.
results
field's
interdisciplinary
nature,
grouped
into
four
main
themes,
including
regenerative
medicine,
scaffolds,
three-dimensional
(3D)
printing,
glass,
tissue
engineering.
Future
research
this
area
will
focus
on
more
effective
precise
systems
using
technologies
like
3D
printing
nanotechnology
enhance
customization
control
release,
aiming
efficient
therapies.
Язык: Английский
Thermo‐Mechanical and Structural Characterization of Isothermally Annealed 3D Printed Pseudo‐Amorphous Polyetherketoneketone (PEKK).
Macromolecular Materials and Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Abstract
Polyetherketoneketone
(PEKK)
(60/40
TERE/ISO)
is
characterized
by
a
lower
processing
temperature
and
higher
glass
transition
(T
g
)
compared
to
polyetheretherketone
(PEEK),
making
it
promising
material
for
3D
printing.
However,
remains
in
amorphous
state
post‐printing
due
its
slow
crystallization
rate.
In
this
study,
isothermal
annealing
conducted
on
printed
pseudo
PEKK
at
various
times
temperature.
Thermal
analysis
techniques
reveal
that
both
time
play
pivotal
role
enhancing
crystallinity,
with
levels
reaching
up
27%
when
annealed
between
the
T
melting
m
).
thermal
stability
decreased
as
approached
.
X‐ray
diffraction
studies
demonstrate
promotes
development
of
stable
form
II
crystals,
while
temperatures
encourages
formation
I
crystals.
Furthermore,
dynamic
mechanical
indicated
44%
increase
stiffness
following
annealing,
compressive
testing
shows
improved
yield
strength,
comparable
other
polyaryletherketone
(PAEK)
materials.
These
findings
suggest
controlled
enables
precise
tailoring
crystallinity
properties,
adaptable
wide
range
applications,
such
biomedical
devices
require
patient‐specific
customization.
Язык: Английский
State-of-the-art of poly(ether ether ketone) matrix reinforced with nanocarbons (carbon nanotube/carbon black) and carbon fibers—promising design, physical attributes and futuristic opportunities
Journal of Thermoplastic Composite Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 21, 2025
This
state-of-the-art
overview
highlights
technical
worth
of
a
high-tech
engineering
thermoplastic
polymer,
poly(ether
ether
ketone),
and
its
hybrids
with
carbonaceous
nanoreinforcements
carbon
fibers.
Accordingly,
literature
up
till
now
reports
on
different
categories
multifunctional
ketone)/carbon
nanotube,
black,
fiber
materials.
These
composites/nanocomposites
have
been
fabricated
through
various
techniques
including
solution
processing,
melt
casting,
prepreg
method,
injection/compression
molding,
three
dimensional
printing,
other
efficient
strategies.
Adding
nanofiller/filler
revealed
significant
enhancements
in
morphological
profiles,
heat
stability,
mechanical
features,
electrical
conductivity,
biological
properties
ketone).
In
the
case
composites,
interfacial
compatibility
superior
physical
performance
achieved
sizing
fibers
(using
nanocarbon
nanoparticles
or
polymers).
Subsequently,
modification
nanoparticles,
fiber,
ketone)
backbone
led
to
technically
high
end
applications
for
aerospace,
fuel
cells,
bone
implants.
Nevertheless,
further
research
regarding
design/structural
optimization,
structure-property
relationships,
property
enhancement
mechanisms
ketone)/nanocarbons
seems
indispensable
unlock
myriad
future
industrial
opportunities,
ranging
from
space/defense—to—energy—to—biomedical
sectors.
Язык: Английский
A Review on Laser Additive Manufacturing of Oxide Dispersion Strengthened Alloys
Опубликована: Янв. 1, 2025
Язык: Английский
Multiscale Mechanical Characterization of Polyether-2-ketone (PEKK) for Biomedical Application
Bioengineering,
Год журнала:
2024,
Номер
11(3), С. 244 - 244
Опубликована: Фев. 29, 2024
Polyether-ether-2-ketone
(PEKK)
is
a
high-performance
thermoplastic
polymer
used
in
various
fields,
from
aerospace
to
medical
applications,
due
its
exceptional
mechanical
and
thermal
properties.
Nonetheless,
the
behavior
of
3D-printed
PEKK
still
deserves
be
more
thoroughly
investigated,
especially
view
production
by
3D
printing,
where
properties
measured
at
different
scales
are
likely
correlated
one
another
all
play
major
role
determining
biomechanical
properties,
which
include
strength
on
side
osteointegration
ability
other
side.
This
work
explores
through
multiscale
approach,
having
performed
both
nanoindentation
tests
standard
tensile
compression
tests,
detailed
strain
distribution
was
achieved
Digital
Image
Correlation
(DIC)
techniques.
Furthermore,
for
specimens
tested
up
failure,
their
fractured
surfaces
were
analyzed
Scanning
Electron
Microscopy
(SEM)
clearly
outline
fracture
modes.
Additionally,
internal
structure
explored
Computed
Tomography
(CT)
imaging,
providing
three-dimensional
presence
voids
imperfections.
Finally,
surface
morphology
confocal
microscopy.
The
approach
adopted
present
offers
information
about
global
local
PEKK,
also
assessing
material
down
nanoscale.
Due
novelty
as
polymeric
material,
no
previous
studies
have
approached
analysis
PEKK.
findings
this
study
contribute
comprehensive
understanding
along
with
criteria
process
optimization
order
customize
meet
specific
application
requirements.
research
not
only
advances
knowledge
3D-printing
but
provides
insights
into
multifaceted
nature
characterization.
Язык: Английский
Poly(ether ether ketone) Nanocomposites with Graphene and Derivative Nanoreinforcements—Contemporary Scientific Paragon and Prospering Breakthroughs
Polymer-Plastics Technology and Materials,
Год журнала:
2024,
Номер
unknown, С. 1 - 25
Опубликована: Дек. 20, 2024
Recently,
poly(ether
ether
ketone)
(PEEK),
an
engineering
thermoplastics,
and
graphene-derived
nanocomposites
emerged
as
promising
structural/device
materials,
attracting
significant
scientific
attention
owing
to
valuable
morphological,
mechanical/thermal
resilience,
electron/heat
transportation,
tribological
features,
biological
properties.
Nevertheless,
despite
their
potential,
there
remains
a
gap
in
comprehensive
understanding
of
mechanical,
wear,
thermal/conductivity,
performance.
Current
review
addresses
this
by
stating
recent
progresses
perusing
key
characteristics
these
ketone)/graphene
nanocomposites.
For
purpose,
we
systematically
categorized
critically
analyzed
the
past/present
literature
multifunctional
ketone)/graphene,
oxide,
ketone)/reduced
graphene
ketone)/surface
modified
graphene/graphene
oxide
hybrids.
We
noticed
variety
manufacturing
strategies,
such
solution
route,
melt
mixing,
situ
method,
injection/compression
molding,
three-dimensional
printing,
allied
tactics
along
with
theoretical
simulation/modeling
for
technological
materials.
Depending
upon
surface
modification,
matrix–nanofiller
interaction,
compatibility,
interface
formation,
PEEK/graphene
hybrids
exposed
high-end
applications
aeronautical
engineering,
fuel
cell
devices,
bone
tissue
scaffold
implantation
purposes.
future
research
on
PEEK/modified
must
focus
advanced
structural
designs,
well-defined
structure–property
relationships,
processing
techniques
well-controllable
parameters,
explorations
mechanism/phenomenon
involved
attain
hi-tech/high
performance
Язык: Английский