Biomedical Journal,
Год журнала:
2023,
Номер
46(5), С. 100663 - 100663
Опубликована: Сен. 28, 2023
This
issue
of
the
Biomedical
Journal
puts
an
emphasis
on
inflammasome
subunits,
NLR
protein
family,
and
role
they
play
in
immunity.
CIITA
is
presented
as
promising
tool
for
augmenting
tumor
immunogenicity.
Several
articles
look
into
involvement
NLRP3
inflammatory
bowel
disease
changes
gut
microbiome,
blood
glucose
management,
sterile
inflammation,
NLRP3's
contribution
to
development
hepatic
encephalopathy.
Furthermore,
a
review
concerning
small
cell
neuroendocrine
carcinoma
cervix
presented,
insights
are
provided
association
knee
pain
patellar
malalignment,
connection
between
hypoxia
sleep
apnea
case
liver
injury
elucidated.
Additional
illuminate
challenge
predicting
influenza
infections;
show
how
ctDNA
may
serve
predictor
survival
outcome
ovarian
carcinoma;
lastly
soft
tissue
after
bimaxillary
rotational
surgery
assessed.
Digestive Diseases and Sciences,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 4, 2024
In
inflammatory
bowel
diseases
(IBD),
the
most
promising
therapies
targeting
cytokines
or
immune
cell
trafficking
demonstrate
around
40%
efficacy.
As
IBD
is
a
multifactorial
inflammation
of
intestinal
tract,
single-target
approach
unlikely
to
solve
this
problem,
necessitating
an
alternative
strategy
that
addresses
its
variability.
One
often
overlooked
by
pharmaceutically
driven
therapeutic
options
address
impact
environmental
factors.
This
somewhat
surprising
considering
increasingly
viewed
as
condition
heavily
influenced
such
factors,
including
diet,
stress,
and
pollution-often
referred
"Western
lifestyle".
IBD,
responses
result
from
complex
interplay
among
genetic
background
patient,
molecules,
cells,
local
microenvironment
where
danger-
microbe-associated
molecular
patterns
(D/MAMPs)
provide
adjuvant-rich
environment.
Through
activating
DAMP
receptors,
array
pro-inflammatory
factors
can
stimulate,
for
example,
NLRP3
inflammasome-a
major
amplifier
response
in
various
cells
via
non-specific
bystander
activation
myeloid
(e.g.,
macrophages)
lymphocytes
tissue-resident
memory
T
cells).
Current
biological
treatment
approaches
dampen
response,
but
without
reducing
exposure
e.g.,
changing
diet
(reducing
ultra-processed
foods),
landscape
never
resolved
continues
drive
mucosal
dysregulation.
Thus,
are
not
enough
put
out
fire.
The
resultant
smoldering,
low-grade
diminishes
physiological
resilience
(micro)environment,
perpetuating
state
chronic
disease.
Therefore,
our
hypothesis
posits
successful
interventions
must
complexity
disease
simultaneously
all
modifiable
aspects:
innate
immunity
microbiota,
adaptive
cytokines,
relate
(micro)environment.
Thus
be
comprehensively
treated
across
nano-,
meso-,
microscales,
rather
than
with
focus
on
single
targets.
A
broader
perspective
also
includes
adapt
DAMPing
(micro)environment
warranted.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11640 - 11640
Опубликована: Окт. 30, 2024
Colorectal
cancer
represents
one
of
the
most
serious
complications
inflammatory
bowel
disease.
The
NLRP3
inflammasome
plays
a
pivotal
role
in
onset
and
progression
disease
is
also
implicated
colorectal
cancer.
This
study
aimed
to
investigate
whether
deficiency
or
glyburide,
sulfonylurea
used
for
diabetes
management
known
as
an
inhibitor,
could
suppress
colitis
its
related
tumorigenesis.
Mice
were
divided
into
three
groups:
control
group,
glyburide
NLRP3-deficient
group.
We
investigated
acute
inflammation-related
tumor
models
using
azoxymethane
dextran
sodium
sulfate.
In
model,
colonic
inflammation
grade
was
significantly
increased
mice
but
not
administered
glyburide.
carcinogenesis
fewer
tumors
observed
both
glyburide-treated
groups.
Additionally,
reduction
expression
levels
cytokine
genes
detected
mucosa
these
These
findings
suggest
that
may
exacerbate
colitis,
while
pharmacological
inhibition,
well
NLRP3,
suppresses
colitis-related
tumorigenesis,
presumably
due
attenuation
chronic
colorectum.
Glyburide
holds
promise
potential
chemopreventive
agent
Microorganisms,
Год журнала:
2024,
Номер
12(4), С. 675 - 675
Опубликована: Март 28, 2024
Cefotaxime
(CTX)
is
an
easily
detectable
antibiotic
pollutant
in
the
water
environment,
but
little
known
about
its
toxic
effects
on
aquatic
invertebrates,
especially
intestine.
Here,
we
determined
oxidative
stress
conditions
of
A.
sinica
under
CTX
exposure
with
five
concentrations
(0,
0.001,
0.01,
0.1
and
1
mg/L)
for
14
days.
After
that,
focused
changes
intestinal
tissue
morphology
gut
microbiota
caused
by
at
0.01
mg/L.
We
found
malondialdehyde
(MDA)
was
elevated
treatment
groups,
suggesting
obvious
antibiotic-induced
stress.
also
mg/L
decreased
villus
height
muscularis
thickness
tissue.
The
16S
rRNA
gene
analysis
indicated
that
reshaped
diversity
community
composition.
Proteobacteria,
Actinobacteriota
Bacteroidota
were
most
widely
represented
phyla
gut.
to
led
absence
Verrucomicrobia
dominant
increase
abundance.
At
genus
level,
eleven
genera
abundance
greater
than
0.1%
exhibited
statistically
significant
differences
among
groups.
Furthermore,
composition
accompanied
modifications
functions,
up-regulation
amino
acid
drug
metabolism
functions
a
down-regulation
xenobiotic
biodegradation
lipid
metabolism-related
exposure.
Overall,
our
study
enhances
understanding
damage
disorder
cefotaxime
which
would
provide
guidance
healthy
aquaculture.
The
anti-inflammatory
properties
of
silkworm
pupa
peptide
(SPP)
have
been
recognized
for
their
potential
benefits
in
colitis
treatment.
However,
the
underlying
mechanism
SPP
animal
models
remains
unclear.
objective
our
work
was
to
investigate
improving
effect
and
action
on
a
mouse
model
dextrose
sodium
sulfate
(DSS)-induced
colitis.
findings
suggested
that
effectively
eased
ulcerative
(UC)
symptoms
mice
by
decreasing
disease
activity
index,
ameliorating
histopathological
injury,
serum
colonic
markers
inflammation.
In
addition,
research
demonstrated
restored
intestinal
barrier
function
increasing
production
tight
junction
proteins
such
as
zonula
occludens-1
(ZO-1),
claudin-1,
claudin-3,
occludin,
adherens
protein
E-cadherin1.
Further,
supplementation
enhanced
concentration
short-chain
fatty
acids
positively
altered
makeup
gut
bacteria
mice's
gut.
These
underscore
SPP's
ability
slow
progression
point
its
possible
use
functional
component
dietary
supplements
prevention
early-stage
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 6167 - 6167
Опубликована: Июнь 3, 2024
Inflammasomes
contribute
to
colorectal
cancer
signaling
by
primarily
inducing
inflammation
in
the
surrounding
tumor
microenvironment.
Its
role
is
receiving
increasing
attention,
as
has
a
protumor
effect
addition
tissue
damage.
The
inflammasome's
function
complex
and
controlled
several
layers
of
regulation.
Epigenetic
processes
impact
functioning
or
manifestation
genes
that
are
involved
control
inflammasomes
subsequent
cascades.
Researchers
have
intensively
studied
significance
epigenetic
mechanisms
regulation,
they
encompass
potential
therapeutic
targets.
regulatory
interactions
between
inflammasome
autophagy
intricate,
exhibiting
both
advantageous
harmful
consequences.
aspects
two
entities
also
relationship
activation
inflammasome,
autophagy,
alterations
CRC
involves
interrelated
pathways.
This
article
provides
brief
summary
newest
studies
on
how
epigenetics
with
special
focus
their
cancer.
Based
latest
findings,
we
provide
an
overview
ideas
for
this
network.
Rheumatology & autoimmunity,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 15, 2024
Abstract
Background
Autoimmune
diseases
are
immune
disorders
in
which
the
system
mistakenly
targets
and
attacks
normal
cells,
tissues,
organs
of
patients.
The
etiology
autoimmune
is
complex
multifactorial.
Objective
This
review
aims
to
provide
a
general
introduction
immunological
functions
inflammasomes
describe
role
characterized
by
self‐directed
inflammation,
with
particular
focus
on
several
common
diseases.
Methods
We
reviewed
current
research
mechanisms
inflammasome
activation
inflammasomes'
contribution
Inhibitors
targeting
components
were
also
explored
for
their
potential
therapeutic
applications.
Results
With
increasing
inflammation
pathologic
conditions,
accumulated
evidence
suggests
that
aberrant
or
uncontrolled
contributes
pathogenesis
development
Additionally,
inflammasome‐targeting
drugs
have
shown
promise
treating
Conclusion
Insights
into
governing
roles
could
contribute
novel
anti‐inflammatory
prevention
treatment
enhanced
precision
reduced
adverse
reactions.
Advanced Gut & Microbiome Research,
Год журнала:
2024,
Номер
2024, С. 1 - 16
Опубликована: Апрель 20, 2024
It
is
becoming
increasingly
clear
that
maintaining
the
equilibrium
of
gut
microbiota
homeostasis
during
viral
infections,
such
as
Hantaan
virus
(HTNV),
paramount
importance.
In
order
to
gain
insight
into
role
NOD-like
receptors
in
immune
system,
we
conducted
a
comparative
study
between
C57BL/6
and
Nlrx1-/-
mouse
models
analyze
changes
after
HTNV
infection.
Our
findings
revealed
an
increase
ratio
Firmicutes
Bacteroides
mice,
suggesting
potential
link
inflammation.
addition,
comprehensive
analysis
serum
metabolomics
differential
metabolites
were
mainly
concentrated
amino
acid
metabolism
lipid
metabolism.
Amino
involves
arginine,
lysine,
histidine
metabolism,
while
related
glycerophospholipid
fatty
synthesis.
Analysis
correlation
inverse
relationship
Bacteroidetes
glutamine
directly
associated
with
these
metabolites.
Furthermore,
observed
negative
presence
Actinobacteria,
Proteobacteria,
Patescibacteria
polyunsaturated
acids
(PUFAs).
results
demonstrate
infection
causes
composition
both
wild-type
(WT)
mice.
Moreover,
fecal
mice
display
notable
differences
at
various
developmental
stages.
Investigating
this
further
may
help
improve
our
understanding
pathogenesis
provide
therapeutic
options.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13689 - 13689
Опубликована: Дек. 21, 2024
Besides
various
infectious
and
inflammatory
complications,
recent
studies
also
indicated
the
significance
of
NLRP3
inflammasome
in
cancer
progression
therapy.
NLRP3-mediated
immune
response
pyroptosis
could
be
helpful
or
harmful
cancer,
depend
on
nature
tumor
microenvironment.
The
activation
increase
surveillance
efficacy
immunotherapy.
It
can
lead
to
removal
cells
by
recruitment
phagocytic
macrophages,
T-lymphocytes,
other
site.
On
hand,
harmful,
as
chronic
inflammation
driven
supports
creating
an
environment
that
facilitates
cell
proliferation,
migration,
invasion,
metastasis.
release
pro-inflammatory
cytokines
such
IL-1β
IL-18
promote
growth
angiogenesis,
while
sustained
may
suppression,
hindering
effective
anti-tumor
responses.
In
this
review
article,
we
discuss
role
inflammasome-mediated
pathophysiology
types;
understanding
is
essential
for
development
innovative
therapeutic
strategies
spread.
Biomedical Journal,
Год журнала:
2023,
Номер
46(5), С. 100663 - 100663
Опубликована: Сен. 28, 2023
This
issue
of
the
Biomedical
Journal
puts
an
emphasis
on
inflammasome
subunits,
NLR
protein
family,
and
role
they
play
in
immunity.
CIITA
is
presented
as
promising
tool
for
augmenting
tumor
immunogenicity.
Several
articles
look
into
involvement
NLRP3
inflammatory
bowel
disease
changes
gut
microbiome,
blood
glucose
management,
sterile
inflammation,
NLRP3's
contribution
to
development
hepatic
encephalopathy.
Furthermore,
a
review
concerning
small
cell
neuroendocrine
carcinoma
cervix
presented,
insights
are
provided
association
knee
pain
patellar
malalignment,
connection
between
hypoxia
sleep
apnea
case
liver
injury
elucidated.
Additional
illuminate
challenge
predicting
influenza
infections;
show
how
ctDNA
may
serve
predictor
survival
outcome
ovarian
carcinoma;
lastly
soft
tissue
after
bimaxillary
rotational
surgery
assessed.
