Sacred codes: preservation, permutation and expression

Biomedical Journal, Год журнала: 2025, Номер unknown, С. 100852 - 100852

Опубликована: Апрель 1, 2025

This issue of the Biomedical Journal features a special section on epigenetics in infection, exploring epitranscriptomic modifications malaria parasite Plasmodium and African sleeping sickness Trypanosoma, with focus how these influence development survival strategies. Additionally, this reviews regulatory mechanisms asymmetric cell division, assessment needs for children developmental coordination disorder along recommendations, advancements 3D chondrocyte culturing tissue engineering. Also examined are three key pathways exacerbating long COVID, increasing impact electromagnetic exposure built environments human health, recent updates liver transplantation criteria hepatocellular carcinoma complicated by portal vein tumor thrombosis. Research bladder cancer investigates role activating transcription factor 3, known its anti-tumor properties, link to metformin. Another study demonstrates efficacy Sanger sequencing streamlining mitochondrial diagnostics, enabling timely identification based clinical evidence. Additional studies present novel intervention approach autoimmune diseases, artificial bone grafts enhance regeneration, benefits public hospital participation oncological trials. Finally, confirms suitability transthoracic echocardiography diagnosing suspected acute aortic syndrome.

Язык: Английский

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Discovery of Cinnamoyl–Flavonoid Hybrid Derivatives as Inhibitors of SARS-CoV-2 Mpro and Anti-inflammatory Agents: Experimental and In Silico Insights into their Efficacy against Lipopolysaccharide-Induced Lung Injury

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177636 - 177636

Опубликована: Апрель 1, 2025

The chemical structures of the parental compounds flavonoids from Boesenbergia rotunda were modified by conjugation with cinnamic acid to form cinnamoyl-flavonoid hybrid derivatives enhanced anti-inflammatory and SARS-CoV-2 Mpro-inhibitory properties. Cinnamoyl-flavonoid 6 10 showed potential inhibit Mpro IC50 values 52.49 22.62 μM. Compounds lower cytotoxicity in human lung cell lines MRC-5 A549 at concentrations greater than 50 effects on viability studied a 3D co-culture model treated lipopolysaccharide (LPS) observed through confocal microscopy. downregulated p65 mRNA expression, resulting reduction pro-inflammatory cytokines, including Interleukin 8 (IL-8) Monocyte Chemoattractant Protein-1 (MCP-1/CCL2), leading an response Nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB) signalling pathways. Compound activity, downregulating Bcl-2 Associated X gene (BAX), which resulted inhibition apoptotic death when compared compound 10. In silico molecular dynamic simulation shed light how these interact myeloid differentiation 2 (MD-2), is involved inflammatory response. Our findings suggest that show as drugs anti-SARS-CoV-2 drugs.

Язык: Английский

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Broad immunogenicity to prior SARS-CoV-2 strains and JN.1 variant elicited by XBB.1.5 vaccination in nursing home residents

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Окт. 12, 2024

Язык: Английский

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Aggravating mechanisms from COVID-19

Virology Journal, Год журнала: 2024, Номер 21(1)

Опубликована: Сен. 27, 2024

Язык: Английский

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