Ferroptosis role in complexity of cell death: unrevealing mechanisms in Parkinson’s disease and therapeutic approaches
Inflammopharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
Язык: Английский
Advances in Ferroptosis Research: A Comprehensive Review of Mechanism Exploration, Drug Development, and Disease Treatment
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 334 - 334
Опубликована: Фев. 26, 2025
In
recent
years,
ferroptosis,
as
an
emerging
modality
of
programmed
cell
death,
has
captured
significant
attention
within
the
scientific
community.
This
comprehensive
review
meticulously
canvasses
pertinent
literature
past
few
spanning
multiple
facets.
It
delves
into
intricate
mechanisms
underpinning
tracks
evolution
its
inducers
and
inhibitors,
dissects
roles
in
a
diverse
array
diseases,
well
resultant
therapeutic
implications.
A
profound
exploration
is
conducted
functional
ferroptosis-related
molecules,
intracellular
pathways,
metabolic
cascades,
signaling
transduction
routes.
Novel
ferroptosis
inhibitors
are
introduced
detail,
covering
their
design
blueprints,
synthetic
methodologies,
bioactivity
profiles.
Moreover,
exhaustive
account
provided
regarding
involvement
malignancies,
neurodegenerative
disorders,
cardiovascular
ailments,
other
pathologies.
By
highlighting
pivotal
status
potential
regimens
various
this
aspires
to
furnish
thorough
reference
framework
for
future
investigations
clinical
translations
domain.
Язык: Английский
Oxazole-Based Ferroptosis Inhibitors with Promising Properties to Treat Central Nervous System Diseases
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
Ferroptosis
plays
an
important
role
in
the
occurrence
and
development
of
many
diseases,
including
neurodegenerative
diseases.
Thus,
ferroptosis
inhibitors
able
to
cross
blood-brain
barrier
may
have
therapeutic
potential.
The
best
so
far
are
lipophilic
radical
trapping
antioxidants
(RTAs)
that
block
lipid
peroxidation
membranes.
Several
generations
ferrostatins
been
synthesized,
among
which
UAMC-3203
showed
high
potency
animal
models
with
improved
properties
compared
ferrostatin-1.
To
further
improve
its
pharmacokinetics
properties,
drug-likeness,
permeability,
we
modified
by
decreasing
size
molecule
reducing
polarity
replacing
sulfonamide
first
amide
groups
subsequently
isosteric
oxazoles.
Herein,
present
design,
synthesis,
biological
evaluation
a
novel
series
oxazole
RTAs
potency,
excellent
oral
bioavailability,
concentrations
brain
tissue.
Язык: Английский
Identification of Imidazo[1,2-a]pyridine-3-amine as a Novel Drug-like Scaffold for Efficious Ferroptosis Inhibition in vivo
European Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown, С. 117516 - 117516
Опубликована: Март 1, 2025
Язык: Английский
Targeting Ferroptosis in Parkinson’s Disease: Mechanisms and Emerging Therapeutic Strategies
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 13042 - 13042
Опубликована: Дек. 4, 2024
Parkinson's
disease
(PD)
is
a
common
neurodegenerative
disorder
characterized
by
the
loss
of
dopaminergic
neurons
in
substantia
nigra
and
accumulation
α-synuclein
brain.
Ferroptosis,
recently
identified
form
regulated
cell
death,
critical
PD
pathogenesis
due
to
its
association
with
iron
deposition,
overproduction
reactive
oxygen
species,
iron-dependent
lipid
peroxidation
impaired
clearance.
This
death
mechanism
closely
linked
several
pathogenic
processes
PD,
including
aggregation,
oxidative
stress,
mitochondrial
dysfunction,
microglia-induced
neuroinflammation,
neuromelanin
accumulation.
Given
significant
role
ferroptosis
these
mechanisms,
there
increasing
interest
targeting
for
treatment.
Several
drugs
have
shown
potential
alleviating
symptoms
inhibiting
ferroptosis.
review
aims
consolidate
current
knowledge
on
assess
therapeutic
anti-ferroptosis
drugs,
highlighting
promising
directions
future
research
clinical
applications.
Язык: Английский
Synthesis and biological evaluation of ferrostatin-based diamide derivatives as new ferroptosis inhibitors
Bioorganic & Medicinal Chemistry Letters,
Год журнала:
2024,
Номер
unknown, С. 129974 - 129974
Опубликована: Сен. 1, 2024
Язык: Английский
Synthesis and evaluation of smart drugs with integrated functions for identifying and treating oxidative microenvironments associated with cellular ferroptosis
Smart Molecules,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 21, 2024
Abstract
Ferroptosis
is
a
novel
form
of
cell
death
driven
by
oxidative
damage,
and
implicated
in
various
pathological
conditions,
including
neurodegenerative
diseases,
retinal
ischemia‐reperfusion
injury
organs.
Inhibiting
ferroptosis
has
shown
great
promise
as
therapeutic
strategy
for
these
underscoring
the
urgent
need
to
develop
effective
inhibitors.
Although
Ferrostatin‐1
(Fer‐1)
potent
inhibitor,
its
susceptibility
oxidation
metabolic
inactivation
limits
clinical
utility.
In
this
study,
accumulation
peroxides
resulting
damage
cellular
microenvironment
during
were
utilized
design
prodrugs
with
reactive
oxygen
species‐responsive
features.
This
approach
led
development
series
inhibitors
that
capable
recognizing
diseased
areas,
allowing
targeted
release
improved
stability.
The
compounds
demonstrated
significant
inhibitory
effects
selectivity
against
RSL‐3‐induced
HK‐2
cells,
compound
a1
exhibiting
an
EC50
15.4
±
0.7
μM,
outperforming
Fer‐1.
These
effectively
identify
associated
ferroptosis,
enabling
Fer‐1,
which
prevents
lipid
peroxide
inhibits
ferroptosis.
holds
treating
diseases
related
offering
intelligent
approach.
Язык: Английский