Abstract
Multidrug
Resistance
(MDR)
can
be
considered
one
of
the
most
frightening
adaptation
types
in
bacteria,
fungi,
protozoa,
and
eukaryotic
cells.
It
allows
organisms
to
survive
attack
many
drugs
used
daily
basis.
This
forces
development
new
more
complex,
highly
specific
fight
diseases.
Given
high
usage
medicaments,
poor
variation
active
chemical
cores,
self‐medication,
appearance
MDR
is
frequent
each
time,
has
been
established
as
a
serious
medical
social
problem.
Over
years
it
possible
identification
several
genes
proteins
responsible
for
with
that
blockers
them
reach
reversion
try
avoid
global
These
mechanisms
also
have
observed
cancer
cells,
calcium
channel
successful
reversion,
maleimide
found
included
them.
In
this
review,
we
explore
particularly
tree
main
involved
chemoresistance,
MRP1
(encoded
by
ABCC1),
BCRP
ABCG2)
P‐gp
ABCB1).
The
participation
remarkably
important,
aspects
its
regulations
are
discussed.
Additionally,
address
history,
mechanisms,
efforts,
specifically
focused
on
synthesis
MDR‐reversers
co‐administration,
well
how
their
biological
applications
imperative
expand
available
information
very
plausible
source.
Abstract
Strategies
for
introducing
halogens
and
other
inorganic
groups
in
aromatic
systems,
usually
involve
non‐general
strong
oxidative
protocols
which
resulted
poor
functional
group
compatibility.
Iodine(III)
reagents
have
emerged
as
an
excellent
alternative
the
functionalization
due
to
their
low
toxicity
character.
In
this
context,
synergistic
combination
of
different
iodine(III)
aluminum
or
ammonium
salts
including
AlCl
3
,
AlBr
Al(NO
)
NH
4
Cl,
Br
I
recently
demonstrated
a
great
versatility
chlorine,
bromine,
iodine
nitro
mainly
phenols,
anilines
some
heterocycles.
Using
these
common
salts,
anions
are
softly
oxidated
by
reagents,
allowing
situ
formation
non‐described
halogenating
nitrating
species
consequence,
introduction
under
umpolung
reactivity
chemical
electrophilic
synthons.
Abstract
Multidrug
Resistance
(MDR)
can
be
considered
one
of
the
most
frightening
adaptation
types
in
bacteria,
fungi,
protozoa,
and
eukaryotic
cells.
It
allows
organisms
to
survive
attack
many
drugs
used
daily
basis.
This
forces
development
new
more
complex,
highly
specific
fight
diseases.
Given
high
usage
medicaments,
poor
variation
active
chemical
cores,
self‐medication,
appearance
MDR
is
frequent
each
time,
has
been
established
as
a
serious
medical
social
problem.
Over
years
it
possible
identification
several
genes
proteins
responsible
for
with
that
blockers
them
reach
reversion
try
avoid
global
These
mechanisms
also
have
observed
cancer
cells,
calcium
channel
successful
reversion,
maleimide
found
included
them.
In
this
review,
we
explore
particularly
tree
main
involved
chemoresistance,
MRP1
(encoded
by
ABCC1),
BCRP
ABCG2)
P‐gp
ABCB1).
The
participation
remarkably
important,
aspects
its
regulations
are
discussed.
Additionally,
address
history,
mechanisms,
efforts,
specifically
focused
on
synthesis
MDR‐reversers
co‐administration,
well
how
their
biological
applications
imperative
expand
available
information
very
plausible
source.
