Role of immune dysregulation in peri-implantitis

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 1, 2024

Peri-implantitis, a complex condition that can lead to dental implant failure, is characterized by inflammatory destruction resulting from immune dysregulation. Oral microbial dysbiosis and foreign body stimulation are the main factors contributing such dysregulation, impairing cell function triggering an response. Immune dysregulation plays critical role in pathophysiology of peri-implantitis, impacting balance T subsets, production factors, immune-related molecular signaling pathways. Understanding relationship between peri-implantitis crucial for developing targeted strategies clinical diagnosis individualized treatment planning. This review explores similarities differences microenvironment oral bacterial infections rejection, analyzes relevant pathways, identifies new key targets innovative immunotherapeutic drugs effective personalized modalities peri-implantitis. Additionally, it addresses challenges potential directions translating immunotherapy into practice offering insights bridge gaps current literature pave way future research.

Язык: Английский

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Multinucleation resets human macrophages for specialized functions at the expense of their identity

EMBO Reports, Год журнала: 2023, Номер 24(3)

Опубликована: Янв. 4, 2023

Abstract Macrophages undergo plasma membrane fusion and cell multinucleation to form multinucleated giant cells (MGCs) such as osteoclasts in bone, Langhans (LGCs) part of granulomas or foreign‐body (FBGCs) reaction exogenous material. How per se contributes functional specialization mature mononuclear macrophages remains poorly understood humans. Here, we integrate comparative transcriptomics with assays purified human osteoclasts, LGCs FBGCs. Strikingly, all three types MGCs, causes a pronounced downregulation macrophage identity. We show enhanced lysosome‐mediated intracellular iron homeostasis promoting MGC formation. The transition from multinuclear state is accompanied by specific each polykaryon. Enhanced phagocytic mitochondrial function associate FBGCs respectively. Moreover, preferentially express B7‐H3 (CD276) can granuloma‐like clusters vitro , suggesting that their potentiates T activation. These findings demonstrate how cell–cell reset identity an advanced maturation step confers MGC‐specific functionality.

Язык: Английский

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Methanolic extract of O.umbellata L. exhibits anti-osteoporotic effect via promoting osteoblast proliferation in MG-63 cells and inhibiting osteoclastogenesis in RANKL-stimulated RAW 264.7 cells

Journal of Ethnopharmacology, Год журнала: 2023, Номер 315, С. 116641 - 116641

Опубликована: Май 24, 2023

Язык: Английский

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Beyond boundaries: unraveling innovative approaches to combat bone-metastatic cancers

Frontiers in Endocrinology, Год журнала: 2024, Номер 14

Опубликована: Янв. 8, 2024

Evidence demonstrated that bones, liver, and lungs are the most common metastasis sites in some human malignancies, especially prostate breast cancers. Bone is third frequent target for spreading tumor cells among these organs tissues. Patients with bone-metastatic cancers face a grim prognosis characterized by short median survival time. Current treatments have proven insufficient, as they can only inhibit or progression within bone tissues rather than providing curative solution. Gaining more profound comprehension of interplay between microenvironment (BME) utmost importance tackling this issue. This knowledge will pave way developing innovative diagnostic therapeutic approaches. review summarizes mechanisms underlying discusses clinical aspects pathologic condition. Additionally, it highlights emerging interventions aimed at enhancing quality life patients affected By synthesizing current research, seeks to shed light on complexities offer insights future advancements patient care.

Язык: Английский

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Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an experimental rat apical periodontitis model

International Endodontic Journal, Год журнала: 2024, Номер 57(9), С. 1315 - 1325

Опубликована: Июнь 24, 2024

Autophagy is involved in human apical periodontitis (AP). However, it not clear whether autophagy protective or destructive bone loss via the receptor activator of nuclear factor-κB ligand (RANKL)/RANK/osteoprotegerin (OPG) axis. This study aimed to investigate involvement RANKL/RANK/OPG axis during development AP an experimental rat model.

Язык: Английский

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