Applied Sciences,
Год журнала:
2024,
Номер
14(17), С. 7566 - 7566
Опубликована: Авг. 27, 2024
Strontium
is
known
for
enhancing
bone
metabolism,
osteoblast
proliferation,
and
tissue
regeneration.
This
systematic
review
aimed
to
investigate
the
biological
effects
of
strontium-doped
calcium
phosphate
biomaterials
therapy.
A
literature
search
up
May
2024
across
Web
Science,
PubMed,
Scopus
retrieved
759
entries,
with
42
articles
meeting
selection
criteria.
The
studies
provided
data
on
material
types,
strontium
incorporation
release,
in
vivo
vitro
evidence.
Strontium-doped
were
produced
via
chemical
synthesis
deposited
various
substrates,
characterization
techniques
confirming
successful
incorporation.
Appropriate
concentrations
non-cytotoxic,
stimulating
cell
adhesion,
osteogenic
factor
production
through
key
signaling
pathways
like
Wnt/β-catenin,
BMP-2,
Runx2,
ERK.
In
identified
novel
formation,
angiogenesis,
inhibition
resorption.
These
findings
support
safety
efficacy
phosphates,
although
optimal
concentration
desired
still
undetermined.
Future
research
should
focus
optimizing
release
kinetics
elucidating
molecular
mechanisms
enhance
clinical
applications
these
engineering.
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(7), С. 178 - 178
Опубликована: Июнь 28, 2024
Zinc
is
known
for
its
role
in
enhancing
bone
metabolism,
cell
proliferation,
and
tissue
regeneration.
Several
studies
proposed
the
incorporation
of
zinc
into
hydroxyapatite
(HA)
to
produce
biomaterials
(ZnHA)
that
stimulate
accelerate
healing.
This
systematic
review
aimed
understand
physicochemical
characteristics
zinc-doped
HA-based
evidence
their
biological
effects
on
osteoblastic
cells.
A
comprehensive
literature
search
was
conducted
from
2022
2024,
covering
all
years
publications,
three
databases
(Web
Science,
PUBMED,
Scopus),
retrieving
609
entries,
with
36
articles
included
analysis
according
selection
criteria.
The
selected
provided
data
material’s
properties,
methods
incorporation,
ZnHA
production
typically
involves
wet
chemical
synthesis
HA
precursors,
followed
by
deposition
substrates
using
processes
such
as
liquid
precursor
plasma
spraying
(LPPS).
Characterization
techniques
confirmed
successful
lattice.
findings
indicated
at
low
concentrations
non-cytotoxic
beneficial
found
adhesion,
osteogenic
factors,
thereby
promoting
vitro
mineralization.
However,
optimal
concentration
desired
varied
across
studies,
making
it
challenging
establish
a
standardized
concentration.
materials
are
biocompatible
enhance
osteoblast
proliferation
differentiation.
mechanisms
release
ideal
regeneration
require
further
investigation.
Standardizing
these
parameters
essential
effective
clinical
application
ZnHA.
Biomimetics,
Год журнала:
2024,
Номер
9(7), С. 386 - 386
Опубликована: Июнь 25, 2024
In
order
to
ensure
improved
and
accelerated
bone
regeneration,
nano-hydroxyapatite
scaffolds
are
often
enriched
with
different
bioactive
components
further
accelerate
improve
healing.
this
review,
we
critically
examined
whether
the
enrichment
of
nHAp/polymer
growth
factors,
hormones,
polypeptides,
microRNAs
exosomes
new
formation
in
vivo.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
17(2), С. 2791 - 2813
Опубликована: Янв. 6, 2025
Transplantation
of
bone
implants
is
currently
recognized
as
one
the
most
effective
means
treating
defects.
Biobased
and
biodegradable
polyester
composites
combine
good
mechanical
degradable
properties
polyester,
thereby
providing
an
alternative
for
implant
materials.
Bone
tissue
engineering
(BTE)
accelerates
defect
repair
by
simulating
microenvironment.
Composite
scaffolds
support
formation
further
accelerate
process
repair.
The
introduction
3D
printing
technology
enables
preparation
to
be
more
precise,
reproducible,
flexible,
which
a
very
promising
development.
This
review
presents
physical
BTE
summarizes
strategies
adopted
domestic
international
scholars
improve
based
on
biobased
polyester/ceramic
in
recent
years.
In
addition,
future
development
prospects
field
challenges
expanding
production
clinical
applications
are
presented.
International Dental Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Hydroxyapatite
nanoparticles
(HANPs)
are
becoming
increasingly
crucial
in
dental
implant
applications
as
they
highly
compatible
with
biological
systems,
actively
support
processes,
and
closely
resemble
bone
minerals.
This
review
covers
the
latest
progress
how
HANPs
made,
studied,
used
dentistry.
It
looks
at
critical
methods
for
creating
HANPs,
such
sol-gel,
microwave
hydrothermal
synthesis,
biomimetic
approaches,
affect
particles'
size,
structure,
activity.
The
green
synthesis
method
illustrated
a
new
door
to
synthesize
HAp
maintaining
biocompatibilityand
increasing
antibacterial
properties.
also
explores
improve
integration
of
implants
bone,
growth,
help
treat
sensitive
teeth
based
on
various
laboratory
clinical
studies.
usage
dentin
enamel
shows
higher
potentiality
through
FTIR,
XPS,
XRD,
EDS,
etc.,
mechanical
stability
balance
compared
natural
teeth.
Additionally,
use
products
like
toothpaste
mouthwash
is
discussed,
highlighting
its
potential
rebuild
tooth
fight
bacteria.
There
some
challenges
long-term
against
oral
bacteria,
but
doping
inorganic
materials,
Zn,
has
already
solved
this
periodontal
problem.
Much
more
research
still
essential
estimate
fabrication
variation
patient
problems
characteristics.
Still,
it
favorable
outcomes
regarding
bioactive
nature
antimicrobial
Due
their
compatibility
tissues
ability
hold
great
promise
advancing
materials
technology,
potentially
leading
better
care
outcomes.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Abstract
Porous
scaffolds
in
bone
tissue
engineering
(BTE)
play
a
crucial
role
facilitating
osteointegration
with
host
tissues
and
providing
nutrients
to
cells
involved
healing.
Scaffold
architecture
influences
osteointegration,
biofunctionality
mechanical
strength,
necessitating
clear
understanding
of
its
impact.
In
this
study,
hydroxyapatite
are
3D
printed
three
types
triply
periodic
minimal
surface
(TPMS)
structures:
gyroid,
lidinoid,
split‐P,
at
porosities
ranging
from
50%
80%.
Split‐P
exhibits
the
highest
compression
between
15
25
MPa,
but
provides
least
area
for
apatite
precipitation.
Conversely,
gyroid
lidinoid
structures
demonstrate
levels
precipitation
across
all
when
immersed
simulated
body
fluid.
To
optimise
scaffold
design,
graded
were
designed
multiple
TPMS
arranged
core‐shell
configuration.
A
structure
featuring
solid
core
70%
shell
achieves
strength
120
while
also
supporting
cell
attachment
differentiation
comparable
that
fully
porous
structure.
This
combination
similar
cancellous
ability
positive
interaction
osteoblast
makes
it
an
ideal
candidate
load‐bearing
applications
BTE.
Polymers,
Год журнала:
2024,
Номер
16(17), С. 2520 - 2520
Опубликована: Сен. 5, 2024
The
development
of
hydroxyapatite
(HAp)
and
polyether
ether
ketone
(PEEK)
biocomposites
has
been
extensively
studied
for
bone
repair
applications
due
to
the
synergistic
properties
involved
materials.
In
this
study,
we
aimed
develop
HAp/PEEK
using
high-energy
ball
milling,
with
HAp
concentrations
(20%,
40%,
60%
w/v)
in
PEEK,
evaluate
their
physicochemical,
mechanical,
cytotoxicity,
antimicrobial
potential
Tissue
Engineering
(TE).
were
characterized
by
structure,
morphology,
apparent
porosity,
diametral
compression
strength,
activity.
study
results
demonstrated
that
successfully
synthesized.
C2
biocomposite,
containing
40%
HAp,
stood
out
optimal
distribution
particles
PEEK
matrix,
resulting
higher
strength
(246
MPa)
a
homogeneous
microstructure.
It
exhibited
activity
against
Staphylococcus
aureus,
Pseudomonas
aeruginosa,
Escherichia
coli,
no
cytotoxicity
observed.
These
make
biocomposite
promising
regenerative
medicine
applications,
combining
mechanical
bioactivity,
biocompatibility.
Nanomaterials,
Год журнала:
2024,
Номер
14(15), С. 1281 - 1281
Опубликована: Июль 30, 2024
Nano-hydroxyapatite
(nHA)
demonstrates
favorable
biological
activity,
cell
adhesion,
proliferation,
and
osteoconductivity,
making
it
highly
valuable
in
biomedicine.
It
is
extensively
used
as
a
bone
substitute
transplantation
within
the
dental
orthopedic
fields.
This
study
employed
oyster
shells
calcium
source
to
synthesize
nHA
at
150
°C
with
various
hydrothermal
reaction
durations
(10
min,
1
h,
6
12
h).
As
control,
HA
synthesized
via
wet
precipitation
method
for
h
room
temperature
was
utilized.
Subsequent
material
analyses,
including
XRD,
FE-SEM,
FTIR,
ICP-MS,
were
conducted,
followed
by
comprehensive
evaluations
of
bioactivity,
attachment,
sintering
properties
nHA.
The
results
indicated
that
through
produced
nanoscale
crystals,
aspect
ratio
particles
increasing
duration
treatment.
Notably,
rod-like
became
prominent
exceeding
h.
derived
from
contained
carbonate
trace
elements
(Na,
Mg,
K,
Sr),
similar
constituents
found
human
hard
tissue
such
teeth.
immersion
(HT2)
simulated
body
fluid
(SBF)
28
d
led
formation
bone-like
apatite
layer
on
surface,
indicating
excellent
bioactivity
culture
revealed
superior
attachment
proliferation
(HT2).
Following
sequential
1200
4
HT2
ceramics
exhibited
enhanced
microhardness
(5.65
GPa)
fracture
toughness
(1.23
MPa·m
