Exploring the Pathophysiology of Anemia in COPD: Insights from Chest CT and Longitudinal Clinical Data

Respiratory Medicine, Год журнала: 2025, Номер unknown, С. 108046 - 108046

Опубликована: Март 1, 2025

Although anemia has been associated with chronic obstructive pulmonary disease (COPD) severity, the underlying risk factors, such as chest imaging indicators, remain poorly understood. In this study, we aimed to investigate relationship between and clinical features, including extrapulmonary indicators on computed tomography (CT), clarify pathophysiology of in COPD. A total 400 patients COPD were prospectively followed for 3 years. Anemia was defined hemoglobin <13 g/dl males <12 females. Patients categorized into non-anemia groups, their characteristics compared. The group exhibited lower percentage predicted forced expiratory volume 1 second (%FEV1) body mass index (BMI) measurements, worse assessment test (CAT) scores, more frequent exacerbations. Imaging revealed severe emphysema, cross-sectional areas pectoralis erector spinae muscles, decreased subcutaneous fat, coronary artery calcification group. Additionally, echocardiography demonstrated a higher prevalence hypertension reduced left ventricular ejection fraction anemia. Three-year longitudinal data analysis further showed that declining levels correlated worsening nutritional status, deterioration bone mineral density (BMD), an increase CAT scores. is multifactorial comorbidity resulting fat muscle mass, BMD.

Язык: Английский

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Erector Spinae Muscle to Epicardial Visceral Fat Ratio on Chest CT Predicts the Severity of Coronavirus Disease 2019

Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 27, 2025

ABSTRACT Background Chest computed tomography (CT) is a valuable tool for diagnosing and predicting the severity of coronavirus disease 2019 (COVID‐19) assessing extrapulmonary organs. Reduced muscle mass visceral fat accumulation are important features body composition phenotype in which obesity loss coexist, but their relationship with COVID‐19 outcomes remains unclear. In this study, we aimed to investigate association between erector spinae (ESM) epicardial adipose tissue (EAT) ratio (ESM/EAT) on chest CT patients COVID‐19. Methods We analysed data from 1074 enrolled Japan Task Force database. The primary outcome was rate critical (requiring high‐flow oxygen therapy, invasive ventilator support or death). incidence compared high low ESM/EAT ratios. Results group ( n = 353) had higher (13.3% vs. 5.13%, p < 0.001) mortality (2.55% 0.69%, 0.019) than 721). multivariable analysis, associated (adjusted odds [aOR] 2.11, 95% confidence interval [CI] 1.22–3.66) independently known factors including age, sex, index (BMI), smoking history, lifestyle‐related comorbidities pneumonia volume. Conclusion can be obtained used predict after onset, demonstrating importance detailed assessments practice.

Язык: Английский

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Morphometric vertebral fractures at hospitalization associate with Long COVID occurrence

Journal of Endocrinological Investigation, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

Язык: Английский

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Unravelling the pandemic: impaired bone metabolism and risk of SARS-CoV-2 infection

Current Medical Research and Opinion, Год журнала: 2025, Номер unknown, С. 1 - 35

Опубликована: Март 17, 2025

Introduction While the impact of COVID-19 on bone metabolism has been extensively studied, inverse relationship remains less understood. This study investigates whether impaired is associated with an increased risk infection.

Язык: Английский

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