A structural perspective on enzymes and their catalytic mechanisms

Current Opinion in Structural Biology, Год журнала: 2025, Номер 92, С. 103040 - 103040

Опубликована: Март 31, 2025

In this perspective, we analyse the progress made in our knowledge of enzyme sequences, structures and functions last 2 years. We review how much new data have been garnered annotated, derived from study proteins using structural computational approaches. Recent advances towards capturing 'Catalysis silico' are described, including predictions structures, their interactions mechanisms. highlight flood data, driven by metagenomic sequencing, improved resources, high coverage Protein Data Bank E.C. classes AI-driven structure prediction techniques that facilitate accurate protein structures. note focus on disordered regions context regulation specificity comment emerging bioinformatic approaches capture reaction mechanisms computationally for comparing predicting also consider drivers field next five

Язык: Английский

Design principles, growth laws, and competition of minimal autocatalysts

Communications Chemistry, Год журнала: 2024, Номер 7(1)

Опубликована: Окт. 21, 2024

Язык: Английский