SSRN Electronic Journal,
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 1, 2023
Rapid
prototyping
is
a
vital
manufacturing
method
for
fabricating
tissue
engineering
scaffolds.
Bone
scaffolds
possess
high
level
of
porosity
to
promote
cell
attachment,
spreading,
and
differentiation
considering
appropriate
biomechanical
properties.
Optimization
various
requirements
parameters
often
requires
extensive
experimental
work.
This
study
aims
design
simulate
3D-printed
PLA
ABS
with
two
lay-down
patterns
potentially
bone
also
distinguishing
the
mechanical
The
CAD-based
were
designed
simulated
finite
element
analysis
(FEA)
determine
3D
printing
technology
has
made
it
possible
produce
that
have
tailored
properties
like
strength,
nutrient
transport,
biological
growth.
comparison
between
indicates
scaffold
holds
higher
potential
being
used
in
regeneration.
Damage
to
bones
resulting
from
trauma
and
tumors
poses
a
significant
challenge
human
health.
Consequently,
current
research
in
bone
damage
healing
centers
on
developing
three-dimensional
(3D)
scaffolding
materials
that
facilitate
enhance
the
regeneration
of
fractured
tissues.
In
this
context,
careful
selection
preparation
processes
is
essential
for
creating
demanding
scaffolds
tissue
engineering.
This
done
optimize
bones.
study
comprehensively
analyses
latest
scientific
advancements
difficulties
creation.
Initially,
we
clarified
composition
process
by
which
repairs
itself.
The
review
summarizes
primary
uses
materials,
both
inorganic
organic,
addition,
present
comprehensive
most
recent
mainstream
techniques
used
prepare
We
also
examine
distinct
advantages
each
method
great
detail.
article
thoroughly
examines
potential
paths
obstacles
engineering
clinical
applications.
Abstract
Given
that
they
can
replicate
both
the
biomechanical
and
mechanobiological
functions
of
natural
bone,
metal
additively
manufactured
porous
load‐bearing
bone
implants
present
a
significant
advancement
in
orthopedic
applications.
Additive
manufacturing
(AM)
metals
enables
precise
control
over
pore
geometry,
resulting
provide
effective
mechanical
support
minimize
stress
shielding.
In
addition
to
its
benefits,
architecture
facilitates
essential
processes,
including
transmission
signals
regulate
cellular
processes
such
as
adhesion,
proliferation,
differentiation.
Before
clinical
use,
should
first
be
engineered
achieve
comparable
elastic
modulus
native
mitigating
implant‐induced
resorption
while
promoting
tissue
regeneration.
It
is
also
noteworthy
microstructural
features
these
angiogenesis‐a
critical
process
for
oxygen
nutrient
delivery
during
healing.
Despite
their
potential
challenges
remain
balancing
stability
applications
with
biofunctionality
integration
controlled
degradation.
This
review
comprehensively
discusses
factors
influencing
design
performance
implants,
highlighting
enhance
outcomes
repair
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Сен. 5, 2024
Bone
structures
facilitate
the
regeneration
and
repair
of
bone
tissue
in
regions
where
it
has
been
damaged
or
destroyed,
either
temporarily
permanently.
Therefore,
bone's
fatigue
strength
durability
are
crucial
to
its
efficacy
longevity.
Several
variables,
such
as
construct's
material
qualities,
design,
production
procedure,
loading
unloading
cycles,
physiological
conditions
influence
endurance
life
constructs.
Metals,
ceramics,
polymers
all
routinely
utilized
create
substitutes,
each
these
materials
unique
features
that
might
affect
final
product.
The
mechanical
performance
capacity
promote
may
be
affected
by
scaffold's
porosity,
pore
size.
Researchers
employ
testing
under
cyclic
circumstances
one
example
an
experimental
approach
used
assess
construction
endurance.
These
analyses
can
give
us
important
information
about
stress-strain
behavior,
resistance
multiple
new
structure.
Predicting
developed
construct
also
possible
with
use
simulations
numerical
analyses.
Hence,
order
reliable
efficient
constructs
for
engineering,
is
understand
their
durability.
purpose
this
study
analyze
effective
parameters
gather
models
evaluations
assessments.
Materials,
Год журнала:
2023,
Номер
16(24), С. 7518 - 7518
Опубликована: Дек. 5, 2023
The
internal
structure
of
the
scaffolds
is
a
key
factor
for
bone
regeneration.
In
this
study,
we
focused
on
space
dimensionality
within
scaffold
that
may
control
cell
migration
and
evaluated
effects
size
orientation
blood
vessels
amount
formation
in
scaffold.
carbonate
apatite
with
intrascaffold
allowing
one-dimensional
(1D),
two-dimensional
(2D),
or
three-dimensional
(3D)
were
fabricated
by
3D
printing.
These
had
same
size,
i.e.,
distances
between
struts
(~300
µm).
implanted
into
medial
condyle
rabbit
femurs
four
weeks.
Both
degree
formed
1D
2.5-
to
4.0-fold
greater
than
those
2D
migration.
Furthermore,
was
1.4-fold
larger
are
probably
because
limited
direction
prevented
branching
vessels,
whereas
spaces
provided
opportunity
random
vessel
branching.
Thus,
advantageous
inducing
large
oriented
resulting
formation.
