bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 22, 2024
The
environment,
especially
social
features,
plays
a
key
role
in
shaping
the
development
of
brain,
notably
during
adolescence.
To
better
understand
variation
brain-environment
coupling
and
its
associated
outcomes,
we
identified
''envirotypes,''
or
different
patterns
environment
experience,
Adolescent
Brain
Cognitive
Development
Study
by
hierarchically
clustering
subjects.
Two
focal
clusters,
which
accounted
for
89.3%
all
participants,
differed
significantly
on
eight
out
nine
youth-report
quality
measures,
representing
almost
perfect
complements.
We
then
applied
tools
from
network
neuroscience
to
show
envirotypes
are
with
whole
brain
functional
connectivity.
Differences
were
distributed
across
but
prominent
Default
Somatomotor
Hand
systems
these
clusters.
Finally,
examined
how
change
over
suite
outcomes.
resulting
dynamic
along
dimensions
stability
quality,
outcomes
diverged
based
stability.
Specifically,
stable,
high
envirotype
was
most
easily
distinguished
improving
envirotype,
while
unstable
worst
Altogether,
our
findings
represent
significant
contributions
both
developmental
neuroscience,
emphasizing
variability
dynamicity
consequences.
Sustainability,
Год журнала:
2025,
Номер
17(5), С. 2057 - 2057
Опубликована: Фев. 27, 2025
One
of
the
central
goals
2030
Agenda
for
Sustainable
Development
is
represented
by
inclusive
and
equitable
education.
This
study
investigates
impact
educational
programs
funded
European
Union
on
socio-economic
situation
Romanian
students
focusing
eight
key
dimensions:
poverty,
social
inequalities,
juvenile
crime,
nutrition,
discrimination,
employability,
quality
life,
health.
The
based
a
quantitative
descriptive
research
design.
data
were
collected
from
representative
sample
1220
pre-university
teachers.
To
identify
differences
between
who
benefited
EU-funded
project
implementation
did
not
have
this
opportunity,
t-Student
ANOVA
tests
used.
cluster
analysis
(k-means)
was
applied
to
classify
cases
evolution
indicators,
binary
logistic
regression
used
factors
influencing
probability
that
belong
groups
with
better
performance
in
relation
analyzed
dimensions.
Our
findings
revealed
while
education
projects
significantly
contributed
development
students,
series
disparities
still
persist
among
coming
low-income
families.
underline
need
more
targeted
policies.
advanced
statistical
analyses
importance
early
interventions
through
programs.
Also,
they
integrated,
strategies
increase
chances
supporting
equity
reducing
inequalities.
Journal of Child Psychology and Psychiatry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 25, 2025
Humans
are
inevitably
exposed
to
multiple
physical
and
social
environmental
risk
factors,
potentially
contributing
psychiatric
problems
cognitive
deficits;
however,
the
combined
effects
of
prenatal
air
pollution
psychosocial
environments
on
youth
remain
unclear.
This
longitudinal
study
aimed
examine
how
ozone
exposure
interacts
with
at
9-10
years
affect
adolescent
limbic
system
development,
cognition,
psychotic-like
experiences
(PLEs)
11-13
years.
We
analyzed
data
from
6,778
participants
in
Adolescent
Brain
Cognitive
Development
(ABCD)
Study®
two
time
points
(baseline:
2-year
follow-up).
Prenatal
was
calculated
as
a
9-month
average
daily
estimates
based
birth
year
address.
Social
factors
included
school
environment
neighborhood
safety
both
points.
Structural
MRI
measures
bilateral
amygdala
hippocampus
volumes
Behavioral
consisted
cognition
PLEs
scores
Moderation
moderated
mediation
models
cluster-robust
standard
errors
were
constructed
effects,
controlling
for
covariates.
Children
who
prenatally
greater
had
more
unfavorable
exhibited
smaller
increase
left
hippocampal
volume,
leading
poorer
PLEs.
Moreover,
children
lived
unsafe
larger
right
volume.
is
first
demonstrate
pollutant
adverse
childhood
highlighting
an
important
neural
mechanism
underlying
effects.
Biological Psychiatry Global Open Science,
Год журнала:
2023,
Номер
4(1), С. 61 - 72
Опубликована: Окт. 14, 2023
Neighborhood
or
area-level
socioeconomic
disadvantage
is
associated
with
neural
alterations
across
the
lifespan.
Few
studies,
however,
have
examined
effects
of
neighborhood
on
white
matter
microstructure
during
adolescence,
an
important
period
development
that
coincides
increased
risk
for
psychopathology.
In
200
adolescents
(ages
13-20
years;
54.5%
female,
4%
non-binary)
recruited
from
two
studies
enriched
early
adversity
and
depression,
we
whether
derived
census
tract
data
was
related
to
in
several
major
tracts.
We
also
depressive
symptoms
sex
moderated
these
associations.
Greater
lower
fractional
anisotropy
(FA)
left
arcuate
fasciculus
(β=-0.24,
FDR-corrected
p=0.035)
right
uncinate
(β=-0.32,
p=0.002),
above
beyond
family-level
status.
Depressive
significantly
association
between
FA
both
(β=0.17,
p=0.026)
unemployment
(β=0.22,
p=0.004),
such
associations
were
only
significant
who
reported
less
severe
depression.
Sex
did
not
moderate
disadvantage,
particularly
poverty
education
attainment
levels,
fasciculus,
measures
These
patterns
observed
low
levels
suggesting
must
be
cautious
about
generalizing
findings
youth
struggle
mental
health
difficulties.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 11, 2024
Abstract
While
the
brain
continues
to
develop
during
adolescence,
such
development
may
depend
on
sex-at-birth.
However,
elucidation
of
differences
be
hindered
by
analytical
decisions
(e.g.,
covariate
selection
address
body/brain-size
differences)
and
typical
reporting
cross-sectional
data.
To
further
evaluate
adolescent
cortical
development,
we
analyzed
data
from
Adolescent
Brain
Cognitive
Development
Study
SM
,
whose
cohort
11,000+
youth
participants
with
biannual
neuroimaging
collection
can
facilitate
understanding
neuroanatomical
change
a
critical
developmental
window.
Doubly
considering
individual
in
context
group-level
effects,
regional
changes
thickness,
sulcal
depth,
surface
area,
volume
between
two
timepoints
(∼2
years
apart)
9-to
12-year-olds
assigned
male
or
female
First,
conducted
linear
mixed-effects
models
gauge
how
controlling
for
intracranial
volume,
whole-brain
(WBV),
summary
metric
mean
thickness)
influenced
interpretations
age-dependent
change.
Next,
evaluated
relative
thickness
area
as
function
sex-at-birth
age.
Here,
showed
that
WBV
(thickness,
volume)
total
were
more
optimal
covariates;
different
covariates
would
have
substantially
altered
our
overall
sex-at-birth-specific
development.
Further,
provided
evidence
suggest
aggregate
is
changing
generally
comparable
across
those
sex-at-birth,
corresponding
happening
at
slightly
older
ages
Overall,
these
results
help
elucidate
trajectories
early
adolescence.
Significance
Statement
most
brain’s
happens
life,
much
it
still
Because
many
factors
alter
trajectories,
important
shape/timing
(i.e.,
what
constitutes
development).
affected
choose
analyze
them.
way
researchers
brain/body
size
affects
interpret
variation
over
time.
consider
similar
patterns
simply
groups.
These
support
relatively
novel
analyzing
Development and Psychopathology,
Год журнала:
2024,
Номер
unknown, С. 1 - 11
Опубликована: Март 22, 2024
The
field
of
developmental
psychopathology
has
grown
exponentially
over
the
past
decades,
and
become
increasingly
multifaceted.
initial
focus
on
understanding
abnormal
child
psychology
broadened
to
study
origins
psychopathology,
with
goals
preventing
alleviating
disorder
promoting
healthy
development.
In
this
paper,
we
discuss
how
technological
advances
global
events
have
expanded
questions
that
researchers
in
can
address.
We
do
so
by
describing
a
longitudinal
been
conducting
for
dozen
years.
originally
planned
examine
effects
early
adversity
trajectories
brain
development,
endocrine
function,
depressive
symptoms
across
puberty;
it
since
an
interdisciplinary
encompassing
diverse
domains
like
inflammation,
sleep,
biological
aging,
environment,
functioning
post-pandemic,
believe
will
advance
our
neurobehavioral
This
increase
breadth
emerged
from
expansion
field;
encourage
embrace
these
dynamic
changes.
context,
challenges,
opportunities,
institutional
changes
related
growing
interdisciplinarity
respect
training
next
generation
investigators
mitigate
burden
mental
illness
youth.