bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 22, 2024
The
environment,
especially
social
features,
plays
a
key
role
in
shaping
the
development
of
brain,
notably
during
adolescence.
To
better
understand
variation
brain-environment
coupling
and
its
associated
outcomes,
we
identified
''envirotypes,''
or
different
patterns
environment
experience,
Adolescent
Brain
Cognitive
Development
Study
by
hierarchically
clustering
subjects.
Two
focal
clusters,
which
accounted
for
89.3%
all
participants,
differed
significantly
on
eight
out
nine
youth-report
quality
measures,
representing
almost
perfect
complements.
We
then
applied
tools
from
network
neuroscience
to
show
envirotypes
are
with
whole
brain
functional
connectivity.
Differences
were
distributed
across
but
prominent
Default
Somatomotor
Hand
systems
these
clusters.
Finally,
examined
how
change
over
suite
outcomes.
resulting
dynamic
along
dimensions
stability
quality,
outcomes
diverged
based
stability.
Specifically,
stable,
high
envirotype
was
most
easily
distinguished
improving
envirotype,
while
unstable
worst
Altogether,
our
findings
represent
significant
contributions
both
developmental
neuroscience,
emphasizing
variability
dynamicity
consequences.
Development and Psychopathology,
Год журнала:
2024,
Номер
unknown, С. 1 - 10
Опубликована: Окт. 9, 2024
Abstract
The
transition
from
childhood
to
adolescence
presents
elevated
risks
for
the
onset
of
psychopathology
in
youth.
Given
multilayered
nature
development,
present
study
leverages
longitudinal,
population-based
Adolescent
Brain
Cognitive
Development
Study
derive
ecologically
informed
risk/resilience
profiles
based
on
multilevel
influences
(e.g.,
neighborhood
and
family
socioeconomic
resources,
parenting,
school
characteristics)
their
pathways
examine
associations
with
psychopathology.
Latent
profile
analysis
characterized
at
each
time
point
(i.e.,
baseline,
Year-1,
Year-2);
latent
estimated
most
likely
pathway
individual.
Analysis
covariance
was
used
between
membership
baseline
ages
9–11)
psychopathology,
both
concurrently
Year-2
follow-up.
Further,
we
examined
Four
distinct
emerged
across
–
High-SES
High-Protective,
Low-Protective,
Low-SES
High-Family-Risk,
High-Protective.
Despite
reasonably
high
stability,
significant
over
among
detected.
Profile
significantly
correlated
concurrent
predicted
2
years
later.
Additionally,
exemplifying
equifinality
multifinality.
Characterizing
tracing
shifts
influences,
our
findings
have
potential
inform
more
precise
intervention
efforts
Frontiers in Neuroimaging,
Год журнала:
2024,
Номер
3
Опубликована: Ноя. 19, 2024
Human
adolescence
marks
a
crucial
phase
of
extensive
brain
development,
highly
susceptible
to
environmental
influences.
Employing
age
estimation
assess
individual
aging,
we
categorized
individuals
(
Abstract
Background
Biopsychosocial
changes
during
adolescence
are
thought
to
confer
risk
for
emotion
dysregulation,
and
in
particular,
anxiety
disorders.
However,
there
substantial
gaps
our
knowledge
about
the
biological
mechanisms
underlying
adolescence,
whether
this
contributes
higher
prevalence
females.
The
Puberty
NeuroDevelopment
Adolescents
(PANDA)
study
aims
examine
links
between
(sex
hormones,
cortisol)
social
environmental
factors
brain
function
with
a
focus
on
key
processes
(emotion
regulation,
fear
learning)
identified
as
relevant
development
of
Methods
PANDA
is
cross-sectional
an
observational
design
that
recruit
total
175
adolescents
aged
11-16
(majority
female)
their
parents/guardians,
from
community.
Brain
will
be
examined
using
magnetic
resonance
imaging
(MRI),
including
functional
MRI
tasks
regulation
learning.
Hormones
measured
hair
(i.e.,
weekly
saliva
samples
oestradiol,
progesterone,
five
across
month
females).
Questionnaires
semi-structured
interviews
used
assess
mental
health
such
parenting
adverse
childhood
experiences.
An
online
113
was
also
incorporated
COVID-19
pandemic
questionnaire-only
sub-study.
Discussion
Strengths
include
collection
multiple
variability
hormone
levels,
examination
timing
experiences,
inclusion
both
maternal
paternal
parental
factors,
exploration
through
structure
function,
multi-method,
multi-informant
symptoms.
This
addresses
important
literature
enhance
contributors
dysregulation
adolescents.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 22, 2024
The
environment,
especially
social
features,
plays
a
key
role
in
shaping
the
development
of
brain,
notably
during
adolescence.
To
better
understand
variation
brain-environment
coupling
and
its
associated
outcomes,
we
identified
''envirotypes,''
or
different
patterns
environment
experience,
Adolescent
Brain
Cognitive
Development
Study
by
hierarchically
clustering
subjects.
Two
focal
clusters,
which
accounted
for
89.3%
all
participants,
differed
significantly
on
eight
out
nine
youth-report
quality
measures,
representing
almost
perfect
complements.
We
then
applied
tools
from
network
neuroscience
to
show
envirotypes
are
with
whole
brain
functional
connectivity.
Differences
were
distributed
across
but
prominent
Default
Somatomotor
Hand
systems
these
clusters.
Finally,
examined
how
change
over
suite
outcomes.
resulting
dynamic
along
dimensions
stability
quality,
outcomes
diverged
based
stability.
Specifically,
stable,
high
envirotype
was
most
easily
distinguished
improving
envirotype,
while
unstable
worst
Altogether,
our
findings
represent
significant
contributions
both
developmental
neuroscience,
emphasizing
variability
dynamicity
consequences.
