Sleep dysfunction mediates the relationship between hypothalamic-insula connectivity and anxiety-depression symptom severity bidirectionally in young adults

NeuroImage, Год журнала: 2023, Номер 279, С. 120340 - 120340

Опубликована: Авг. 22, 2023

The hypothalamus plays a crucial role in regulating sleep-wake cycle and motivated behavior. Sleep disturbance is associated with impairment cognitive affective functions. However, how hypothalamic dysfunction may contribute to inter-related sleep, cognitive, emotional deficits remain unclear.We curated the Human Connectome Project dataset investigated resting state functional connectivities (rsFC) were sleep dysfunction, as evaluated by Pittsburgh Quality Index (PSQI), performance, subjective mood states 687 young adults (342 women). Imaging data processed published routines corrected threshold. We examined inter-relationship amongst rsFC, PSQI score, clinical measures mediation analyses.In whole-brain regressions age drinking severity covariates, men showed higher rsFC right insula correlation score. No clusters identified women at same Both hypothalamic-insula score significantly correlated anxiety depression scores men. Further, analyses that mediated relationship between anxiety/depression symptom bidirectionally men.Sleep negative emotions insula, core structure of interoceptive circuits. Notably, anxiety-depression altered are related poor quality. These findings specific men, suggesting potential sex differences neural circuits need be further investigated.

Язык: Английский

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Shared and distinct neural activity during anticipation and outcome of win and loss: A meta-analysis of the monetary incentive delay task

NeuroImage, Год журнала: 2022, Номер 264, С. 119764 - 119764

Опубликована: Ноя. 24, 2022

Язык: Английский

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Deficient sleep, altered hypothalamic functional connectivity, depression and anxiety in cigarette smokers

Neuroimage Reports, Год журнала: 2024, Номер 4(1), С. 100200 - 100200

Опубликована: Март 1, 2024

Deficient sleep is implicated in nicotine dependence as well depressive and anxiety disorders. The hypothalamus regulates the sleep-wake cycle supports motivated behavior, hypothalamic dysfunction may underpin comorbid dependence, depression anxiety. We aimed to investigate whether how resting state functional connectivities (rsFCs) of relate cigarette smoking, deficient sleep, used data 64 smokers 198 age- sex-matched adults who never smoked, curated from Human Connectome Project. psychiatric problems were each assessed with Pittsburgh Sleep Quality Index (PSQI) Achenbach Adult Self-Report. processed imaging published routines evaluated results at a corrected threshold, all age, sex, severity alcohol use covariates. Smokers vs. showed poorer quality greater In only, total PSQI score, indicating more deficits, was positively associated rsFCs right inferior frontal/insula/superior temporal postcentral (rPoCG) gyri. Stronger hypothalamus-rPoCG also but not smokers. Additionally, smokers, score completely mediated relationships severity. These findings associate circuit deficiency symptoms smoke. Future studies roles behaviors better characterize inter-related neural markers

Язык: Английский

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The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Abstract Genetic factors contribute to alcohol misuse. Chronic consumption is associated with decreases in gray matter volumes (GMVs) of the brain. However, it remains unclear whether or how genetic risks may alter GMVs independent effects exposure. Here, we employed Human Connectome Project data neurotypical adults (n = 995; age 22-35; 618 women) and, voxel-based morphometry analysis, computed 166 regions automated anatomical atlas 3. Alcohol use behaviors were assessed Semi-Structured Assessment for Genetics Alcoholism. severity was quantified by first principal component (PC1) identified analysis 15 drinking measures. Polygenic risk scores (PRS) dependence all subjects using Psychiatric Genomics Consortium study as base sample. With age, sex, race, and total intracranial volume covariates, evaluated relationships regional PC1 PRS together a linear regression. negatively correlated right insula Heschl’s gyrus, positively left posterior orbitofrontal cortex, bilateral intralaminar nuclei thalamus lingual gyri. These findings suggest distinct volumetric neural markers Notably, contrast reduction, dependent involve larger reward, emotion, saliency circuits.

Язык: Английский

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Hypothalamic resting-state functional connectivity and self-evaluated aggression in young adults

Journal of Psychiatric Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Determinants of substance use patterns in patients with narcolepsy type 1: a multi-center comparative cross-sectional study

Sleep Medicine, Год журнала: 2025, Номер 129, С. 148 - 166

Опубликована: Фев. 26, 2025

Язык: Английский

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Connectomics modeling of regional networks of white-matter fractional anisotropy to predict the severity of young adult drinking

Quantitative Imaging in Medicine and Surgery, Год журнала: 2025, Номер 15(3), С. 2405 - 2419

Опубликована: Март 1, 2025

Alcohol use impacts brain structure, including white matter integrity, which can be quantified by fractional anisotropy (FA) in diffusion tensor imaging (DTI). This study explored the relationship between severity of alcohol consumption and FA changes, its sex differences, young adults, using data from Human Connectome Project. We analyzed DTI 949 participants (491 females) used principal component analysis (PCA) 15 drinking metrics to quantify severity. Connectome-based predictive modeling (CPM) was employed predict network values a matrix 116×116 regions. Mediation analyses were conducted explore interrelationships among networks identified CPM, severity, rule-breaking behavior. Significant correlations found values. Both men women showed significant negative connectivity (men: r=0.15, P=0.001; women: r=0.30, P<0.001). Sex differences observed regions contributing predictions. revealed inter-relationships features, The connectomics consumption, incorporating pathways, identify differences. approach provides new clues biological basis abuse evaluates how these interact broader for understanding misuse comorbidities.

Язык: Английский

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Sleep Deficits Inter-Link Lower Basal Forebrain–Posterior Cingulate Connectivity and Perceived Stress and Anxiety Bidirectionally in Young Men

The International Journal of Neuropsychopharmacology, Год журнала: 2023, Номер 26(12), С. 879 - 889

Опубликована: Окт. 31, 2023

Abstract Background The basal nucleus of Meynert (BNM), a primary source cholinergic projections to the cortex, plays key roles in regulating sleep-wake cycle and attention. Sleep deficit is associated with impairment cognitive emotional functions. However, whether or how circuit, sleep, cognitive/emotional dysfunction are inter-related remains unclear. Methods We curated Human Connectome Project data explored BNM resting state functional connectivities (rsFC) relation sleep deficit, based on Pittsburgh Quality Index (PSQI), performance, subjective reports states 687 young adults (342 women). Imaging were processed published routines evaluated at corrected threshold. assessed correlation between rsFC, PSQI, clinical measurements Pearson regressions their inter-relationships mediation analyses. Results In whole-brain age alcohol use severity as covariates, men showed lower rsFC posterior cingulate cortex (PCC) PSQI score. No clusters identified women same Both BNM-PCC score significantly correlated anxiety, perceived stress, neuroticism scores men. Moreover, analyses that mediated relationship these measures negative emotions bidirectionally Conclusions PCC. Negative related through poor quality. These findings specific men, suggesting potential sex differences neural circuits states.

Язык: Английский

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Polygenic risk for depression and resting state functional connectivity of subgenual anterior cingulate cortex in young adults

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 21, 2024

Abstract Genetic variants may confer risks for depression by modulating brain structure and function. Prior evidence has underscored a key role of the subgenual anterior cingulate cortex (sgACC) in depression. Here, we built on literature examined how resting state functional connectivity (rsFC) sgACC was associated with polygenic We followed published routines computed seed-based whole-brain rsFC risk scores (PRS) 717 young adults curated from Human Connectome Project. performed regression against PRS severity symptoms single model all subjects men women alone, controlling age, sex (for all), race, alcohol use, household income, evaluated results at corrected threshold. found lower default mode network frontal regions association sgACC-cerebellar severity. also noted differences correlates In an additional set analyses, observed significant correlation between somatic complaints score altered sgACC-somatosensory cortical link complaints. Our findings collectively highlighted pivotal distinct sgACC-based networks genetic predisposition to clinical manifestation Distinguishing markers have implications developing early effective treatments individuals

Язык: Английский

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Functional Networks of Reward and Punishment Processing and Their Molecular Profiles Predicting the Severity of Young Adult Drinking

Brain Sciences, Год журнала: 2024, Номер 14(6), С. 610 - 610

Опубликована: Июнь 18, 2024

Alcohol misuse is associated with altered punishment and reward processing. Here, we investigated neural network responses to the molecular profiles of connectivity features predicting alcohol use severity in young adults. We curated Human Connectome Project data employed connectome-based predictive modeling (CPM) examine how functional (FC) during wins losses are severity, quantified by Semi-Structured Assessment for Genetics Alcoholism, 981 combined CPM findings JuSpace toolbox characterize severity. The connectomics appeared specific, comprising less than 0.12% all features, including medial frontal, motor/sensory, cerebellum/brainstem networks processing fronto-parietal, motor/sensory Spatial correlation analyses showed that these were predominantly serotonergic GABAa signaling. To conclude, a distinct pattern predicted adult drinkers. These “neural fingerprints” elucidate impacts brain provide evidence new targets future intervention.

Язык: Английский

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