Cognitive Impairment in Psychotic Disorders Is Associated with Brain Reductive Stress and Impaired Energy Metabolism as Measured by 31P Magnetic Resonance Spectroscopy
Schizophrenia Bulletin,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Abstract
Background
and
Hypothesis
Convergent
evidence
shows
the
presence
of
brain
metabolic
abnormalities
in
psychotic
disorders.
This
study
examined
reductive
stress
energy
metabolism
people
with
disorders
impaired
or
average
range
cognition.
We
hypothesized
that
global
cognitive
impairment
would
be
associated
greater
dysregulation.
Study
Design
Participants
affective
non-affective
psychosis
(n
=
62)
were
administered
MATRICS
Consensus
Cognitive
Battery
(MCCB)
underwent
a
31P-magnetic
resonance
spectroscopy
scan
at
4T.
used
cluster-analysis
approach
to
identify
2
clusters
participants
without
dysfunction.
compared
on
redox
balance
stress,
measured
by
ratio
nicotinamide
adenine
dinucleotide
(NAD+)
its
reduced
form
NADH,
addition
creatine
kinase
(CK)
enzymatic
activity
pH.
Results
The
mean
(SD)
age
was
25.1
(6.3)
years.
NAD+/NADH
differed
between
groups,
lower
ratio,
suggesting
more
cluster
(t
−2.60,
P
.01).
There
also
significant
reduction
CK
−2.19,
.03).
Intracellular
pH
did
not
differ
groups
1.31,
.19).
significantly
severity
mood
symptomatology
other
measures
illness
severity.
Conclusions
Our
results
demonstrate
have
dysregulation,
decrease
rate
markers.
provides
new
for
potential
emerging
therapies
treat
deficits
Язык: Английский
The Association Among Bipolar Disorder, Mitochondrial Dysfunction, and Reactive Oxygen Species
Biomolecules,
Год журнала:
2025,
Номер
15(3), С. 383 - 383
Опубликована: Март 6, 2025
Mitochondria,
often
known
as
the
cell’s
powerhouses,
are
primarily
responsible
for
generating
energy
through
aerobic
oxidative
phosphorylation.
However,
their
functions
extend
far
beyond
just
production.
Mitochondria
play
crucial
roles
in
maintaining
calcium
balance,
regulating
apoptosis
(programmed
cell
death),
supporting
cellular
signaling,
influencing
metabolism,
and
synthesizing
reactive
oxygen
species
(ROS).
Recent
research
has
highlighted
a
strong
link
between
bipolar
disorder
(BD)
mitochondrial
dysfunction.
Mitochondrial
dysfunction
contributes
to
stress,
particularly
generation
of
ROS,
which
implicated
pathophysiology
BD.
Oxidative
stress
arises
when
there
is
an
imbalance
production
ROS
ability
neutralize
them.
In
neurons,
excessive
can
damage
various
components,
including
proteins
neuronal
membranes
intracellular
enzymes.
Such
may
interfere
with
neurotransmitter
reuptake
function
critical
enzymes,
potentially
affecting
brain
regions
involved
mood
regulation
emotional
control,
key
aspects
this
review,
we
will
explore
how
types
contribute
ROS.
These
include
disruptions
impaired
management,
defects
quality
control
mechanisms
such
mitophagy
(the
process
by
damaged
mitochondria
selectively
degraded).
We
also
examine
abnormalities
synaptic
plasticity,
lead
Additionally,
discuss
specific
dysfunctions
observed
BD,
highlighting
these
disorder’s
pathophysiology.
Finally,
identify
potential
therapeutic
targets
improve
function,
could
pave
way
new
treatments
manage
or
mitigate
symptoms
Язык: Английский
Ketogenic diet, adenosine, and dopamine in addiction and psychiatry
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Март 10, 2025
Adhering
to
the
ketogenic
diet
can
reduce
or
stop
seizures,
even
when
other
treatments
fail,
via
mechanism(s)
distinct
from
available
therapies.
These
results
have
led
interest
in
for
treating
conditions
such
as
Alzheimer’s
disease,
depression
and
schizophrenia.
Evidence
points
neuromodulator
adenosine
a
key
mechanism
underlying
therapeutic
benefits
of
diet.
Adenosine
represents
unique
direct
link
among
cell
energy,
neuronal
activity,
gene
expression,
receptors
form
functional
heteromers
with
dopamine
receptors.
The
importance
dopaminergic
system
is
established
addiction,
are
challenges
modulating
directly.
A
mediator
that
could
antagonize
dopamine’s
effects
would
be
useful,
due
its
function
location.
Studies
report
improves
cognition,
sociability,
perseverative
behaviors,
might
improve
depression.
Many
translational
opportunities
based
on
diet/adenosine
come
fore,
including
autism
spectrum
disorder,
painful
conditions,
range
hyperdopaminergic
disorders.
Язык: Английский
Challenges and Frontiers in Computational Metabolic Psychiatry
Опубликована: Авг. 13, 2024
One
of
the
primary
challenges
in
metabolic
psychiatry
is
that
disrupted
brain
functions
underlie
psychiatric
conditions
arise
from
a
complex
set
downstream
and
feedback
processes
spanning
across
multiple
spatiotemporal
scales.
Importantly,
same
circuit
can
have
points
failure,
each
which
results
different
type
dysregulation,
thus
elicits
distinct
cascades
produce
divergent
signs
symptoms.
Here,
we
illustrate
this
challenge
by
examining
how
subtle
differences
perturbations
lead
to
clinical
outcomes.
We
also
discuss
computational
models
perform
spatially
heterogenous
integration
bridge
vitro
vivo
paradigms.
By
leveraging
recent
methodological
advances
tools,
integrate
relevant
scales
(e.g.,
TCA-cycle,
ion
channel,
neural
microassembly,
whole-brain
macro-circuit)
physiological
systems
neural,
endocrine,
immune,
vascular),
providing
framework
unite
these
mechanistic
manner
goes
beyond
conceptual
descriptive,
quantitative
generative.
These
hold
potential
sharpen
our
intuitions
towards
circuit-based
for
personalized
diagnostics
treatment.
Язык: Английский