Impact of Maternal Stress and COVID-19 Exposure During Pregnancy on Offspring Neurodevelopment: Signature Cohort 12 Month Follow-Up DOI Creative Commons
Nathalia Garrido-Torres,

Andrés Román-Jarrín,

J. Alfred Rider

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 2, 2024

Abstract The COVID-19 pandemic brought unprecedented global challenges. Amid the crisis, potential impact of exposure on neurodevelopment offspring born to infected mothers emerged as a critical concern. This is prospective cohort study exposed mild or severe during pregnancy. Pregnant women who acquired SARS-CoV-2 were enrolled in SIGNATURE project at Hospital Universitario Virgen del Rocio Seville, Spain, between 01/01/2021 and 08/31/2022. Maternal stress was assessed through Perceived Stress Scale; screened Ages & Stages Questionnaire, 3rd Edition (ASQ-3) 6 months 12 months. Association severity neurodevelopmental outcomes analyzed with univariate multivariate analysis. included 689 categorized into three distinct groups based severity: non-infected (N = 277), 358), 54). In utero infection nearly tripled risk developmental concern ASQ-3 personal-social subdomain follow-up [OR 2.751 (95% CI 1.065–7.106), p 0.037], independently timing maternal stress. While this did not yield statistically significant results, it highlights need further investigate association pregnancy understand long-term consequences prenatal exposure.

Язык: Английский

The Autism Spectrum Disorder and Its Possible Origins in Pregnancy DOI Open Access
Rayane Martins Botelho, Ana Lúcia M. Silva, Alexandre Urban Borbely

и другие.

International Journal of Environmental Research and Public Health, Год журнала: 2024, Номер 21(3), С. 244 - 244

Опубликована: Фев. 20, 2024

Autism Spectrum Disorder (ASD) belongs to the group of neurodevelopmental disorders, and has a high prevalence, affecting 1 in 100 children according data from World Health Organization (WHO). To be diagnosed with ASD, child must have persistent deficits communication social interactions, restricted repetitive patterns behavior, interests, or activities. Despite its etiology ASD is still uncertain, multifactorial characteristics, including those associated gestational period, where maternal exposure biological, chemical, physical hazards occurs, some which already been proposed as causes outcomes. Since pregnancy requires balance between maternal–fetal binomial, breakdown this caused by such environmental can lead altered fetal neurodevelopment, ASD. With firmly mind, review aims compile most recent on that may development help health professionals identify risk factors act for prevention management

Язык: Английский

Процитировано

8
The influence of asthma on neuroinflammation and neurodevelopment: From epidemiology to basic models DOI Creative Commons
Juan M. Tamayo,

H. Osman,

Jared J. Schwartzer

и другие.

Brain Behavior and Immunity, Год журнала: 2023, Номер 116, С. 218 - 228

Опубликована: Дек. 8, 2023

Asthma is a highly heterogeneous inflammatory disease that can have significant effect on both the respiratory system and central nervous system. Population based studies animal models found asthma to be comorbid with number of neurological conditions, including depression, anxiety, neurodevelopmental disorders. In addition, maternal during pregnancy has been associated disorders in offspring, such as autism spectrum attention deficit hyperactivity disorder. this article, we review most current epidemiological identify links it relates individuals suffer from impacts may offspring neurodevelopment. We also discuss relevant investigating these links, address gaps knowledge, explore potential future directions field.

Язык: Английский

Процитировано

12
Immune Alterations in the Intrauterine Environment Shape Offspring Brain Development in a Sex-Specific Manner DOI
Elisa Guma, M. Mallar Chakravarty

Biological Psychiatry, Год журнала: 2024, Номер 97(1), С. 12 - 27

Опубликована: Апрель 26, 2024

Язык: Английский

Процитировано

5
Is Autism a PIN1 Deficiency Syndrome? A Proposed Etiological Role for Glyphosate DOI Open Access
Stephanie Seneff, Anthony M. Kyriakopoulos, Greg Nigh

и другие.

Authorea (Authorea), Год журнала: 2024, Номер unknown

Опубликована: Март 28, 2024

Autism is a neurodevelopmental disorder whose prevalence has increased dramatically in the United States over past two decades.It characterized by stereotyped behaviors and impairments social interaction communication.In this paper, we present evidence that autism can be viewed as PIN1 deficiency syndrome.PIN1 (Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1) peptidylprolyl cis/trans isomerase, it widespread influences biological organisms.Broadly speaking, linked to many neurodegenerative diseases, whereas overexpression cancer.Death associated protein kinase 1 (DAPK1) strongly inhibits PIN1, hormone melatonin DAPK1.Melatonin autism.It recently been shown glyphosate exposure rats synthesis due glutamate release from glial cells expression of metabotropic receptors.Glyphosate's inhibition leads reduction availability neurons.In show explain unique morphological features autism, including dendritic spine density, missing or thin corpus callosum reduced bone density.We how disrupts functioning powerful high level signaling molecules, such nuclear factor erythroid 2-related 2 (NRF2) p53.Dysregulation both these proteins autism.Severe depletion glutathione brain resulting chronic oxidative stressors extracellular oxidation cysteine residue inactivating further contributing deficiency.Impaired autophagy sensitivity neurons ferroptosis.Finally, consider potential toxic effects mRNA SARS-CoV-2 vaccines light metabolic defects propose children with would especially sensitive damage vaccines.

Язык: Английский

Процитировано

1
Autism likelihood in infants born to mothers with asthma is associated with blood inflammatory gene biomarkers in pregnancy DOI Creative Commons
Vanessa E. Murphy, Olivia M. Whalen, Evan J. Williams

и другие.

Brain Behavior & Immunity - Health, Год журнала: 2024, Номер 40, С. 100845 - 100845

Опубликована: Авг. 13, 2024

Mothers with asthma or atopy have a higher likelihood of having autistic children, maternal immune activation in pregnancy implicated as mechanism. This study aimed to determine, prospective cohort mothers and their infants, whether inflammatory gene expression is associated future autism. were recruited the Breathing for Life Trial. RNA was extracted from blood samples collected at mid-pregnancy. 300 ng total hybridized nCounter Human Inflammation panel (Nanostring Technologies, 249 inflammation-related genes). Parents completed First Year Inventory (FYI) 12-month follow-up, which assessed an infant's autism across 2 behavioural domains: social communication sensory regulation. A score ≥19.2 indicated increased Inflammatory profiled 24 mothers: four infants scored high range; 20 low range. Six genes differentially expressed significantly up-regulated group:

Язык: Английский

Процитировано

1
Maternal immune activation and autism in the offspring—what is the evidence for causation? DOI Creative Commons
Renee M. Gardner, Martin Brynge, Hugo Sjöqvist

и другие.

Biological Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

1
Short Communication: Profiling of activated monocyte populations in autism and associations with increased severity and comorbid behaviors DOI Creative Commons

Elizabeth Breece,

Rachel J. Moreno,

Yasmin W. Azzam

и другие.

Brain Behavior and Immunity, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

1
The association of maternal COVID-19-infection during pregnancy on the neonatal immune profile and associations with later diagnosis of neurodevelopmental disorders DOI Creative Commons
Danielle Kim, Lisa Croen, Ana‐Maria Iosif

и другие.

Brain Behavior and Immunity, Год журнала: 2024, Номер 123, С. 1071 - 1080

Опубликована: Ноя. 10, 2024

Язык: Английский

Процитировано

0
The Association Between In Utero Exposure to Painkillers and Trajectories of Hyperactivity and Emotional Problems in Children with Autism Compared with Neurotypical Peers DOI Creative Commons
Ping‐I Lin,

Kyi Shinn Khin,

James Rufus John

и другие.

Children, Год журнала: 2024, Номер 11(12), С. 1558 - 1558

Опубликована: Дек. 23, 2024

Background/Objectives: In utero exposure to painkillers has raised concerns regarding its potential impact on neurodevelopmental disorders, such as autism spectrum disorder (ASD). This study investigates the association between in and trajectories of hyperactivity emotional problems children with without ASD, separately. Methods: Data were drawn from 5107 participants enrolled Longitudinal Study Australian Children. Emotional behavioral assessed using Strengths Difficulties Questionnaire at ages 4, 6, 8 years. ASD diagnosis was determined based parental self-report by age 12. To examine outcomes, mixed linear models applied assess problems, controlling for sex, time, other perinatal risk factors. The interaction term time included evaluate effect trajectory over time. Results: did not significantly affect or problem ASD. However, non-ASD children, painkiller associated worsening 8, males being affected a greater extent than females. Further, scores increased gender, reflecting developmental challenges early childhood. Conclusions: These findings indicate that prenatal is unlikely be major determinant severity outcomes autistic but role among neurotypical warrants further investigation. Future research should prioritize precise assessments integrate multi-environment interactions elucidate long-term impacts use.

Язык: Английский

Процитировано

0
The Impact of Maternal Inflammatory Conditions During Pregnancy on the Risk of Autism: Methodological Challenges DOI Creative Commons
Ali S. Khashan, Gerard W. O’Keeffe

Biological Psychiatry Global Open Science, Год журнала: 2024, Номер 4(2), С. 100287 - 100287

Опубликована: Март 1, 2024

Язык: Английский

Процитировано

0