Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment DOI Creative Commons

Noreen Samad,

Ayesha Hameed,

Natasha Manzoor

и другие.

Experimental Gerontology, Год журнала: 2024, Номер 198, С. 112624 - 112624

Опубликована: Ноя. 9, 2024

Aging is an invincible phenomenon that a risk factor for the development of neurological disorders such as anxiety, depression, and memory decline are prominent in aging. The present study aims to evaluate effect Niacin (Nn) on D-galactose (D-Gal)-induced behavioral deficits impairment rats. In experiment, forty-eight male albino Sprague dwaley rats were divided random basis into six groups (n = 8): Veh + Veh, Nn (low dose), (high D-Gal, D-Gal+Nn dose). 300 mg/kg/mL drug doses while low (25 mg/kg/mL) high (50 used this study. Animals received their respective treatment 14 days (intraperitoneally, once daily). After days, animals subjected different tests including light-dark box activity, elevated plus maze test (for anxiety), tail suspension depression). A Morris water was performed short-term long-term performance. tests, decapitation brains collected stored biochemical neurochemical analysis. Behavioral analysis revealed alleviated anxiety depression-like symptoms induced by D-Gal. D-Gal-induced decreased antioxidant enzymes, acetylcholine levels, increased oxidative stress markers, neuro-inflammatory cytokines, serotonin metabolism, acetylcholinesterase (AChE) activity prevented administration at both doses. In-silico studies showed has potential inhibit AChE with binding affinity -5.0 kcal/mol. conclusion, neuromodulator could be helpful treating aging associated psychiatric illnesses.

Язык: Английский

Berberine attenuates brain aging via stabilizing redox homeostasis and inflammation in an accelerated senescence model of Wistar rats DOI
Arun Kumar Yadawa, Parisha Srivastava, A. L. Singh

и другие.

Metabolic Brain Disease, Год журнала: 2024, Номер 39(5), С. 649 - 659

Опубликована: Май 10, 2024

Язык: Английский

Процитировано

2
Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment DOI Creative Commons

Noreen Samad,

Ayesha Hameed,

Natasha Manzoor

и другие.

Experimental Gerontology, Год журнала: 2024, Номер 198, С. 112624 - 112624

Опубликована: Ноя. 9, 2024

Aging is an invincible phenomenon that a risk factor for the development of neurological disorders such as anxiety, depression, and memory decline are prominent in aging. The present study aims to evaluate effect Niacin (Nn) on D-galactose (D-Gal)-induced behavioral deficits impairment rats. In experiment, forty-eight male albino Sprague dwaley rats were divided random basis into six groups (n = 8): Veh + Veh, Nn (low dose), (high D-Gal, D-Gal+Nn dose). 300 mg/kg/mL drug doses while low (25 mg/kg/mL) high (50 used this study. Animals received their respective treatment 14 days (intraperitoneally, once daily). After days, animals subjected different tests including light-dark box activity, elevated plus maze test (for anxiety), tail suspension depression). A Morris water was performed short-term long-term performance. tests, decapitation brains collected stored biochemical neurochemical analysis. Behavioral analysis revealed alleviated anxiety depression-like symptoms induced by D-Gal. D-Gal-induced decreased antioxidant enzymes, acetylcholine levels, increased oxidative stress markers, neuro-inflammatory cytokines, serotonin metabolism, acetylcholinesterase (AChE) activity prevented administration at both doses. In-silico studies showed has potential inhibit AChE with binding affinity -5.0 kcal/mol. conclusion, neuromodulator could be helpful treating aging associated psychiatric illnesses.

Язык: Английский

Процитировано

1