Elsevier eBooks, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Journal of Psychiatry and Brain Science, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
The aging population of the world is increasing at an unprecedented rate which expected to lead a corresponding unparalleled increase in age related diseases. Of particular concern are large number older adults develop Alzheimer's disease (AD), will require extraordinary local, national and worldwide healthcare resources. In this context, innovative interventions needed urgently delay AD onset thereby give our systems time prepare provide meaningful care populations. This focused review discusses crucial role frontal gamma oscillations as therapeutic target or ameliorate cognitive decline AD. Frontal oscillations, including from prefrontal cortical areas, serve biomarker for working memory other functions, their impairment observed before clinical symptoms manifest. evaluates evidence animal models human subjects highlight correlation between wave abnormalities deterioration. Furthermore, summarizes 11 studies using neuromodulation techniques designed stimulate mild (MCI) patients, transcranial electrical stimulation, magnetic rhythmic sensory stimulation. These have shown promise mitigating early-stage decline, evidenced by improved performance on tests, increased oscillatory responses, some even reduced brain atrophy. early suggest that treatments strengthen responses through promising approach may adjunct therapies standalone treatment
Язык: Английский
Процитировано
5
Science Advances, Год журнала: 2024, Номер 10(44)
Опубликована: Окт. 30, 2024
Because of the depth hippocampal-entorhinal complex (HC-EC) in brain, understanding its role spatial navigation via neuromodulation was limited humans. Here, we aimed to better elucidate this relationship healthy volunteers, using transcranial temporal interference electric stimulation (tTIS), a noninvasive technique allowing selectively neuromodulate deep brain structures. We applied tTIS right HC-EC either continuous or intermittent theta-burst patterns (cTBS iTBS), compared control condition, during virtual reality–based task and concomitant functional magnetic resonance imaging. iTBS improved performance, correlated with hippocampal activity modulation, decreased grid cell–like EC. Collectively, these data provide evidence that human can be directly noninvasively modulated leading changes behavior. These findings suggest promising perspectives for patients suffering from cognitive impairment such as following traumatic injury dementia.
Язык: Английский
Процитировано
4
Molecular Psychiatry, Год журнала: 2025, Номер unknown
Опубликована: Апрель 4, 2025
Язык: Английский
Процитировано
0
The Journal of Headache and Pain, Год журнала: 2024, Номер 25(1)
Опубликована: Окт. 17, 2024
This study investigated for a possible contributing role of hippocampus in the different clinical phenotypic manifestations migraine aura.
Язык: Английский
Процитировано
2
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Июнь 10, 2024
Abstract Background Advances in the development of neurotechnologies have potential to revolutionize treatment brain-based conditions. However, a critical concern revolves around willingness public embrace these technologies, especially considering tumultuous histories certain neurosurgical interventions. Therefore, examining attitudes is paramount uncovering barriers adoption ensuring ethically sound innovation. Methods In present study, we investigate towards use four (within-subjects conditions): deep brain stimulation (DBS), transcranial magnetic (TMS), pills, and MRI-guided focused ultrasound (MRgFUS) as treatments person experiencing either mood, memory, or motor symptoms (between-subjects conditions). US-based participants (N=1052; stratified be nationally representative based on sex, race, age) were asked about their perceptions risk, benefit, invasiveness, acceptability, perceived change person, personal interest using for symptom alleviation. Results Descriptive results indicate variability between technologies that U.S. willing consider if severe symptoms. The main effect neurotechnology revealed DBS was viewed most invasive risky lead greatest who someone person. also least likely personally used acceptable by others. When effects symptomatology, found all forms neuromodulation significantly more beneficial, acceptable, symptoms, followed memory lastly mood Neuromodulation (averaging across neurotechnologies) riskier, invasive, leading greater versus symptoms; however, similarly with respect Conclusion These suggest views neuromodulatory approaches require surgery (i.e., MRgFUS) less than those do not. Further, findings individuals may reluctant alter treat psychological compared physical
Язык: Английский
Процитировано
0
Опубликована: Июнь 25, 2024
Associative memory (AM) is a domain vital for normal cognitive functioning. It declines over time due to healthy aging as well in various neurological conditions. Standard transcranial electrical stimulation (tES) protocols show inconclusive facilitatory effects on AM, often lacking function specificity and focality. We tested the effectiveness of high-density electrode montage delivering anodal theta oscillatory-modulated direct current (HD-Theta-otDCS) left posterior parietal cortex (PPC), aiming target AM spatially focused function-specific manner. In sham-controlled cross-over experiment, we explored differential HD-Theta-otDCS applied during either encoding or retrieval phases two tasks (Face-Word Object-Location). The protocol consisted an anode PPC (P3) four surrounding return electrodes (CP1, CP5, PO3, POz) with oscillating rhythm (5Hz, 1.5 ± 0.5mA). both (p=0.020, ηp2=0.22) (p=0.005, ηp2=0.32) increased performance compared sham control Face-Word task. found no differences between active showed be promising tool enhancing regardless timing. results provide further support our previous findings bipolar otDCS confirm that can induce behaviorally relevant modulation memory-related cortico-subcortical networks. Significance: presented approach one step forward towards precision brain neuromodulation. novelty lies combination focality waveform. Positive set ground research HD-theta-otDCS clinical samples.
Язык: Английский
Процитировано
0
Clinical Neurophysiology, Год журнала: 2024, Номер 170, С. 80 - 90
Опубликована: Дек. 12, 2024
Язык: Английский
Процитировано
0
RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, Год журнала: 2024, Номер 5(12), С. e5126039 - e5126039
Опубликована: Дек. 16, 2024
Deep Brain Stimulation (DBS) is a safe and promising neurologic technique for the treatment of Alzheimer's disease (AD), neurodegenerative condition prevalent in elders. This paper reviews application DBS specific targets brain, such as fornix, entorhinal cortex (EC), nucleus basalis Meynert (NBM), thalamic nuclei. The studies were analyzed it showed that can make brain metabolism better, reduce inflammation, stabilize cognitive downstage, resulting better quality life patients. Although these results sound very promising, variety answers suggests need personalizing stimulation parameters more research to optimize this therapeutic approach.
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0