Unveiling the impact of aging on BBB and Alzheimer's disease: Factors and therapeutic implications

Ageing Research Reviews, Год журнала: 2024, Номер 98, С. 102224 - 102224

Опубликована: Фев. 10, 2024

Язык: Английский

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PEGylated-liposomal astaxanthin ameliorates Aβ neurotoxicity and Alzheimer-related phenotypes by scavenging formaldehyde

Journal of Controlled Release, Год журнала: 2024, Номер 366, С. 783 - 797

Опубликована: Янв. 20, 2024

Язык: Английский

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Astaxanthin ameliorates high-carbohydrate diet-induced ER stress, immunosuppression and hepatic glucose metabolism through AMPK/autophagy pathway in Channa argus

Aquaculture, Год журнала: 2024, Номер 598, С. 742010 - 742010

Опубликована: Дек. 13, 2024

Язык: Английский

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Approaches for Increasing Cerebral Efflux of Amyloid-β in Experimental Systems

Journal of Alzheimer s Disease, Год журнала: 2024, Номер 100(2), С. 379 - 411

Опубликована: Июнь 14, 2024

Amyloid protein-β (Aβ) concentrations are increased in the brain both early onset and late Alzheimer's disease (AD). In AD, cerebral Aβ production is its clearance decreased, while burden AD due to impaired clearance. has been focus of therapeutics since development amyloid hypothesis, but efforts slow progression by lowering failed until phase 3 trials with monoclonal antibodies lecanemab donanemab. addition promoting phagocytic Aβ, lower efflux Aβ-antibody complexes across capillary endothelia, dissolving aggregates, a "peripheral sink" mechanism. Although blood-brain barrier main route which soluble leaves (facilitated low-density lipoprotein receptor-related protein-1 ATP-binding cassette sub-family B member 1), can also be removed via blood-cerebrospinal fluid barrier, glymphatic drainage, intramural periarterial drainage. This review discusses experimental approaches increase these mechanisms, clinical applications approaches, findings patients or mild cognitive impairment. Based on negative previous targeting monomeric increasing unlikely if used as monotherapy. But an adjunct treatment donanemab, this approach might allow greater slowing than either antibody alone.

Язык: Английский

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A marine-derived antioxidant astaxanthin as a potential neuroprotective and neurotherapeutic agent: A review of its efficacy on neurodegenerative conditions

European Journal of Pharmacology, Год журнала: 2024, Номер 977, С. 176706 - 176706

Опубликована: Июнь 5, 2024

Язык: Английский

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Autophagy-targeted therapy for pulmonary inflammation by 2D MX2 (M = W, Nb; X = S, Se) nanosheets

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Astaxanthin Inhibits Ferroptosis of Hippocampal Neurons in Kainic Acid‐Induced Epileptic Mice by Activating the Nrf2/GPX4 Signaling Pathway

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(2)

Опубликована: Фев. 1, 2025

ABSTRACT Background Epilepsy, a prevalent neurological disorder, is distinguished by episodic abnormal discharges of neurons within the brain, resulting in transient brain dysfunction. Prior research has identified novel form cell death termed ferroptosis, which intricately linked to initiation and progression epilepsy. It been demonstrated that astaxanthin (AST) can inhibit ferroptosis enhancing activity nuclear factor erythroid 2‐related 2 (Nrf2), thereby providing cytoprotection. Therefore, this study aims investigate whether AST alleviate neuronal epilepsy activating Nrf2/GPX4 pathway, exerting neuroprotective effect. Methods By constructing kainic acid (KA)‐induced mouse model KA‐induced HT22 model, we employed behavioral testing, Western blot analysis, quantitative real‐time reverse transcription qRT‐PCR, ferroptosis‐related assay kits, immunofluorescence staining, other methods. These methodologies were utilized protective effects underlying mechanisms on epileptic mice neurons. Results Our results demonstrate pretreatment alleviates behaviors cognitive impairments mitigates indicators such as lipid peroxidation mitochondrial morphological alterations. This effect appears be mediated activation signaling axis. In vitro studies further revealed confers neuroprotection against death, an abrogated Nrf2 inhibitor. Hence, properties are significantly associated with modulation Nrf2‐mediated corroborated bioinformatics analyses. Conclusion The effectively inhibits both vivo models via pathway. finding suggests holds promise potential therapeutic agent for treatment

Язык: Английский

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Role of Chinese Medicine Monomers in Dry Eye Disease: Breaking the Vicious Cycle of Inflammation

Pharmacology Research & Perspectives, Год журнала: 2025, Номер 13(2)

Опубликована: Фев. 20, 2025

Dry eye disease (DED) is a chronically inflammatory ocular surface disorder of unknown pathogenesis. Anti-inflammatory medications, artificial tears, autologous serum, and LipiFlow have been shown to be highly beneficial in alleviating symptoms. Nevertheless, these interventions often provide only short-term results do not address the underlying problems disease. There growing evidence that risk DED associated with vicious cycle inflammation. This inflammation produced by interaction several factors, including tear film hyperosmolarity, instability, inflammation, apoptosis. Chinese medicine monomers, distinguished their multicomponent multitarget advantages, help treat modulating status, inhibiting responses, apoptosis, providing new way thinking management medicine.

Язык: Английский

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The Advancements of Marine Natural Products in the Treatment of Alzheimer’s Disease: A Study Based on Cell and Animal Experiments

Marine Drugs, Год журнала: 2025, Номер 23(3), С. 91 - 91

Опубликована: Фев. 20, 2025

As life expectancy rises and the aging population grows, Alzheimer’s disease (AD) has become a significant global health concern. AD is complex neurodegenerative disorder with an unclear etiology. Current hypotheses primarily focus on β-amyloid (Aβ) aggregation, tau protein hyperphosphorylation, neuroinflammation as key pathological processes. Given limited efficacy of existing therapeutic strategies, there urgent need to explore novel treatment options. Marine natural products have garnered attention due their unique chemical structures diverse bioactivities, demonstrating potential for multi-target interventions in AD. This review systematically summarizes roles marine-derived compounds, including polysaccharides, carotenoids, polyphenols, modulating Aβ mitigating pathology, regulating gut–brain axis dysfunction. Furthermore, challenges current research are discussed, emphasis improving blood–brain barrier permeability optimizing drug delivery systems facilitate clinical translation.

Язык: Английский

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Neurodegenerative diseases and neuroinflammation-induced apoptosis

Open Life Sciences, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 1, 2025

Abstract Neuroinflammation represents a critical pathway in the brain for clearance of foreign bodies and maintenance homeostasis. When neuroinflammatory process is dysregulate, such as over-activation microglia, which results excessive accumulation free oxygen inflammatory factors brain, among other factors, it can lead to an imbalance homeostasis development various diseases. Recent research has indicated that numerous neurodegenerative diseases closely associated with neuroinflammation. The pathogenesis neuroinflammation intricate, involving alterations genes proteins, well activation inhibition signaling pathways. Furthermore, inflammation result neuronal cell apoptosis, further exacerbate extent disease. This article presents summary recent studies on relationship between apoptosis caused by aim identify link two provide new ideas targets exploring pathogenesis, prevention treatment

Язык: Английский

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