Exosomes and tissue engineering: A novel therapeutic strategy for nerve regenerative

Tissue and Cell, Год журнала: 2024, Номер 93, С. 102676 - 102676

Опубликована: Дек. 13, 2024

Язык: Английский

---

Research progress of ferroptosis in brain injury

Deleted Journal, Год журнала: 2024, Номер unknown, С. 1 - 14

Опубликована: Ноя. 10, 2024

Ferroptosis, a regulated form of cell death characterized by iron-dependent lipid peroxidation, has emerged as key contributor to neuronal damage in various types brain injury, including traumatic injury (TBI) and ischemic caused brian ischemia (BI). This review summarizes the underlying mechanisms ferroptosis injuries highlights its role exacerbating loss, inflammation, secondary damage. After TBI, release free iron oxidative stress after triggers ferroptosis, contributing long-term neurological deficits. Similarly, BI, is initiated accumulation reactive oxygen species (ROS) mitochondrial dysfunction during reperfusion, further amplifying The current provides comprehensive overview interplay between with an emphasis on potential targeting improve recovery outcomes patients. Future research directions include development novel inhibitors integration ferroptosis-targeting strategies existing treatment modalities.

Язык: Английский

---

Unveiling the predictive power of biomarkers in traumatic brain injury: A narrative review focused on clinical outcomes

Biomedical Papers, Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

Traumatic brain injury (TBI) has long-term consequences, including neurodegenerative disease risk. Current diagnostic tools are limited in detecting subtle damage. This review explores emerging biomarkers for TBI, those related to neuronal injury, inflammation, EVs, and ncRNAs, evaluating their potential predict clinical outcomes like mortality, recovery, cognitive impairment. It addresses challenges opportunities implementing practice, aiming improve TBI diagnosis, prognosis, treatment.

Язык: Английский

---