Functional Neural Connectivity of the Mouse Brain using Photoacoustic Ultrasound Imaging DOI Creative Commons

Isaac Clark,

Andrew Heinmiller,

Wei Zhu

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Brain connectomes are insightful models that describe the connectivity of different regions throughout brain. These traditionally generated through temporal correlation blood oxygen level dependent (BOLD) signals detected by functional magnetic resonance imaging (fMRI). Photoacoustic ultrasound (PAU) can also detect oxygenation levels while being more accessible and cost effective than fMRI. We propose use PAU to generate brain as an alternative In this study we successfully developed a pipeline for processing data from whole scans mice found it produced were comparable those fMRI, particularly, in detecting connections previously documented literature. Our findings suggest is promising fMRI mapping connectome, offering advantages sensitivity accessibility, making valuable tool future research on connectivity.

Язык: Английский

Auditory research across time: Insights from an interdisciplinary publishing platform DOI Creative Commons
Andréanne Sharp

Brain Research, Год журнала: 2025, Номер unknown, С. 149453 - 149453

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Candidate Key Proteins in Tinnitus—A Bioinformatic Study of Synaptic Transmission in the Inferior Colliculus DOI Open Access

Johann Gross,

Marlies Knipper, Birgit Mazurek

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1831 - 1831

Опубликована: Фев. 20, 2025

Proteins involved in synaptic transmission normal hearing, acoustic stimulation, and tinnitus were identified using protein–protein interaction (PPI) networks. The gene list for was compiled from the GeneCards database keywords “synaptic transmission” AND “inferior colliculus” “tinnitus” (Tin). For comparison, two lists built “auditory perception” (AP) “acoustic stimulation” (AS). STRING Cytoscape data analyzer used to identify top high-degree proteins (HDPs) corresponding high-score (HSIP). top1 key of AP AS processes are BDNF receptor NTRK2; top2 process PVALB, together with GAD1, CALB1, CALB2, which important balance excitation inhibition. In process, FOS, CREB1, EGR1, MAPK1, reflecting an activated state. Tin BDNF, NTRK3, NTF3; these associated proliferation differentiation neurons indicate remodeling IC. GFAP S100B, indicating a role astrocytes modulation transmission.

Язык: Английский

Процитировано

0
Functional Neural Connectivity of the Mouse Brain using Photoacoustic Ultrasound Imaging DOI Creative Commons

Isaac Clark,

Andrew Heinmiller,

Wei Zhu

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Brain connectomes are insightful models that describe the connectivity of different regions throughout brain. These traditionally generated through temporal correlation blood oxygen level dependent (BOLD) signals detected by functional magnetic resonance imaging (fMRI). Photoacoustic ultrasound (PAU) can also detect oxygenation levels while being more accessible and cost effective than fMRI. We propose use PAU to generate brain as an alternative In this study we successfully developed a pipeline for processing data from whole scans mice found it produced were comparable those fMRI, particularly, in detecting connections previously documented literature. Our findings suggest is promising fMRI mapping connectome, offering advantages sensitivity accessibility, making valuable tool future research on connectivity.

Язык: Английский

Процитировано

0