Auditory research across time: Insights from an interdisciplinary publishing platform
Brain Research,
Год журнала:
2025,
Номер
unknown, С. 149453 - 149453
Опубликована: Янв. 1, 2025
Язык: Английский
Candidate Key Proteins in Tinnitus—A Bioinformatic Study of Synaptic Transmission in the Inferior Colliculus
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 1831 - 1831
Опубликована: Фев. 20, 2025
Proteins
involved
in
synaptic
transmission
normal
hearing,
acoustic
stimulation,
and
tinnitus
were
identified
using
protein–protein
interaction
(PPI)
networks.
The
gene
list
for
was
compiled
from
the
GeneCards
database
keywords
“synaptic
transmission”
AND
“inferior
colliculus”
“tinnitus”
(Tin).
For
comparison,
two
lists
built
“auditory
perception”
(AP)
“acoustic
stimulation”
(AS).
STRING
Cytoscape
data
analyzer
used
to
identify
top
high-degree
proteins
(HDPs)
corresponding
high-score
(HSIP).
top1
key
of
AP
AS
processes
are
BDNF
receptor
NTRK2;
top2
process
PVALB,
together
with
GAD1,
CALB1,
CALB2,
which
important
balance
excitation
inhibition.
In
process,
FOS,
CREB1,
EGR1,
MAPK1,
reflecting
an
activated
state.
Tin
BDNF,
NTRK3,
NTF3;
these
associated
proliferation
differentiation
neurons
indicate
remodeling
IC.
GFAP
S100B,
indicating
a
role
astrocytes
modulation
transmission.
Язык: Английский
Functional Neural Connectivity of the Mouse Brain using Photoacoustic Ultrasound Imaging
Isaac Clark,
Andrew Heinmiller,
Wei Zhu
и другие.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Brain
connectomes
are
insightful
models
that
describe
the
connectivity
of
different
regions
throughout
brain.
These
traditionally
generated
through
temporal
correlation
blood
oxygen
level
dependent
(BOLD)
signals
detected
by
functional
magnetic
resonance
imaging
(fMRI).
Photoacoustic
ultrasound
(PAU)
can
also
detect
oxygenation
levels
while
being
more
accessible
and
cost
effective
than
fMRI.
We
propose
use
PAU
to
generate
brain
as
an
alternative
In
this
study
we
successfully
developed
a
pipeline
for
processing
data
from
whole
scans
mice
found
it
produced
were
comparable
those
fMRI,
particularly,
in
detecting
connections
previously
documented
literature.
Our
findings
suggest
is
promising
fMRI
mapping
connectome,
offering
advantages
sensitivity
accessibility,
making
valuable
tool
future
research
on
connectivity.
Язык: Английский